Review
Nutrition & Dietetics
Jeremy R. Townsend, Trevor O. Kirby, Tess M. Marshall, David D. Church, Adam R. Jajtner, Ralph Esposito
Summary: Human nutrition is a complex topic that is still not fully understood, resulting in global nutritional problems such as malnutrition or overconsumption. Factors contributing to this problem include limitations in recommended daily allowances and dietary reference intakes, changes in soil quality, and reductions in nutrient density. In this article, a new approach called Foundational Nutrition is proposed, which combines whole food approach, crucial micronutrients, and consideration of gut health to enhance bioavailability and bioactive effects of nutrients.
Article
Cell Biology
Fabiola Olivieri, Francesco Prattichizzo, Fabrizia Lattanzio, Anna Rita Bonfigli, Liana Spazzafumo
Summary: One of the challenges in aging research is to understand how genetics and environmental factors interact to determine the chances of reaching extreme human lifespan in good health. Epigenetic mechanisms provide an explanation for this interaction and the long-term effects of lifestyle on aging. The theory of inflammaging suggests that chronic low-grade inflammation plays a crucial role in age-related diseases and mortality. Studies on centenarians have shown that healthy individuals can upregulate anti-inflammatory responses to cope with inflammaging. Genetic factors and the ability to remodel metabolic pathways are also important for healthy aging. The concept of antifragility, which refers to the ability of complex systems to perform better under stress, may provide insights into the heterogeneous nature of the aging process and its relationship with inflammation.
AGEING RESEARCH REVIEWS
(2023)
Article
Physiology
Xinan Li, Yaping Li, Xun Zhu, Xiangrui Li, Dengfa Cheng, Yunhui Zhang
Summary: Field populations of insect pests are affected by sub-lethal doses of insecticides, leading to hormesis. Imidacloprid significantly reduced the fecundity, adult longevity, and reproductive period of M. dirhodum in parental generation (F-0), but stimulated the population growth of filial generation (F-1).
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Gonzalez-Rodriguez, Jens Fullgrabe, Bertrand Joseph
Summary: Historical and demographical studies on human populations exposed to famine, along with animal studies, have shown that exposure to food deprivation has long-lasting health effects on the individuals and can also affect the disease risk and overall longevity of their offspring. Autophagy, a cellular process that helps cope with nutrient starvation, has been found to improve health span and extend lifespan in multiple model organisms, including through dietary regimes based on reduced food intake. Furthermore, autophagy-induced chromatin remodeling, such as DNA methylation and histone posttranslational modifications, are proposed as a plausible mechanism for the transgenerational epigenetic inheritance of hunger.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Bryndon J. Oleson, Daphne Bazopoulou, Ursula Jakob
Summary: Studies have shown that genetically identical animals in the same environment can have variability in lifespan, with stochastic factors playing a role. Recent research suggests that variations in reactive oxygen species levels early in life can contribute to lifespan variability and act as stochastic factors in aging. Developmental events can positively influence lifespan and stress responses through a redox-sensitive epigenetic regulator.
Article
Multidisciplinary Sciences
Qin-Li Wan, Xiao Meng, Chongyang Wang, Wenyu Dai, Zhenhuan Luo, Zhinan Yin, Zhenyu Ju, Xiaodie Fu, Jing Yang, Qunshan Ye, Zhan-Hui Zhang, Qinghua Zhou
Summary: Obesity is a major risk factor to human health and can be inherited across generations through epigenetic mechanisms. This study established a nematode model to investigate the network of lipid metabolic genes and chromatin modifications involved in transgenerational obesogenic effects.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Yeh Siang Lau, Ming Tsuey Chew, Amal Alqahtani, Bleddyn Jones, Mark A. Hill, Andrew Nisbet, David A. Bradley
Summary: The concept of radiation-induced hormesis, where low doses are beneficial and high doses are detrimental, is gaining attention in various scientific fields. There is ongoing debate about the magnitude and mechanism of this hormetic dose response, which could have therapeutic implications for human health in the future. Studies explore both the beneficial and detrimental effects of low dose ionizing radiation-induced hormesis, along with the underlying mechanisms that may provide insights for future treatments.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Snehasis Biswas, Jayesh Bellare
Summary: This study found that pretreatment of zebrafish with a sparingly soluble mercury compound can induce adaptive mechanisms that resist the neurotoxic effects of mercury chloride. Biochemical and proteomics studies showed that pretreatment prevents alteration of reactive oxygen species and various protein expressions related to oxidative stress. This research provides new insights for the treatment of mercury toxicity.
Review
Medicine, General & Internal
Adam Li, Zane Koch, Trey Ideker
Summary: Numerous studies have shown that epigenetic age is associated with various factors and can be computed based on DNA methylation patterns. The focus of research needs to shift from accurate age prediction to understanding the links between the epigenome and aging mechanisms. Current research areas include epigenetic clocks and investigation of the epigenome to build a mechanistic theory of aging and inform clinical practice.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Alfonso Varela-Lopez, Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Cesar L. Ramirez-Tortosa, Maurizio Battino, Tamara Y. Forbes-Hernandez, Jose L. Quiles
Summary: The increase in life expectancy in current societies has not been accompanied by a corresponding increase in healthspan, which is a significant socio-economic problem. It has been suggested that manipulating the aging process can delay the onset of age-related chronic disorders, as these pathologies share age as the primary underlying risk factor. The accumulation of molecular damage is one of the widely accepted theories of aging. According to the oxidative damage theory, antioxidants are expected to slow down aging, extending both lifespan and healthspan. This review examines studies on the effects of dietary antioxidants on lifespan in different aging models, and discusses the evidence supporting their antioxidant activity as anti-aging mechanisms. Furthermore, possible reasons for discrepancies in the reported results are evaluated.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Agronomy
Sandra R. R. Ethridge, Saket Chandra, Anna M. M. Locke, Wesley J. J. Everman, David L. L. Jordan, Micheal D. K. Owen, Ramon G. G. Leon
Summary: This research study observed changes in growth characteristics and competitive ability of a weed species, Abutilon theophrasti Medik., across multiple generations. The study also investigated changes in sensitivity to herbicides over time. The results indicate that the weed has rapidly evolved increased competitive ability and changes in response to herbicides.
PEST MANAGEMENT SCIENCE
(2023)
Article
Environmental Sciences
Wenxin Wang, Muhammad Hafeez, Hong Jiang, Waseem Ahmad, Hammad Badar, Raufhon Salahodjaev
Summary: BRICS economies are facing severe environmental issues that affect human health. The study finds that CO2 emissions have a negative impact on life expectancy, but a positive impact on the death rate. Environmental innovations and environmental policy stringency have positive effects on life expectancy, but the effect is insignificant for the death rate. The study suggests that the BRICS economies should reassess their environmental policies for the betterment of human health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Edward J. Calabrese, Peter Pressman, A. Wallace Hayes, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese, Evgenios Agathokleous, Ivo Iavicoli, James Giordano
Summary: The paper identifies a critical factor that leads to false negative results in human drug trials. It demonstrates that human performance can only be enhanced by a maximum of 30-60% due to the limits of biological plasticity. Clinical trials often require responses greater than 2-3 times control group responses to show statistical significance, causing potentially beneficial agents to be missed. The paper proposes a weight-of-evidence methodology to address this conundrum.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Johannes Burtscher, Robert T. Mallet, Vincent Pialoux, Gregoire P. Millet, Martin Burtscher
Summary: In this article, the authors review the current understanding of how the human body adapts to low and high oxygen levels and discuss their potential therapeutic and performance-enhancing applications. They highlight the importance of hypoxia conditioning as a preparation for severe hypoxic insults and the potential benefits of combining it with hyperoxic interventions in the treatment of chronic diseases and for performance enhancement.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Cell Biology
Fedor Galkin, Olga Kovalchuk, Diana Koldasbayeva, Alex Zhavoronkov, Evelyne Bischof
Summary: Epigenetic aging clocks are valuable tools for predicting age-related health conditions and studying the mechanisms of aging. This review examines the effects of modifiable lifestyle factors on DNA methylation levels and discusses their contribution to biological aging. It also provides insights for individuals interested in adopting an evidence-based longevity lifestyle.
AGEING RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Alexander Vaiserman, Oleh Lushchak
JOURNAL OF TRANSLATIONAL MEDICINE
(2017)
Article
Geriatrics & Gerontology
Dmytro S. Krasnienkov, Mykola D. Khalangot, Victor Kravchenko, Volodymyr A. Kovtun, Vitaly G. Guryanov, Valentina P. Chizhova, Oleg Korkushko, Valery B. Shatilo, Vitaly M. Kukharsky, Alexander M. Vaiserman
EXPERIMENTAL GERONTOLOGY
(2018)
Article
Cell Biology
Alexander M. Vaiserman
MECHANISMS OF AGEING AND DEVELOPMENT
(2018)
Article
Cell & Tissue Engineering
Khrystyna Sorochynska, Nataliia Sych, Alla Duda, Kateryna Kulebyakina, Dmytro Krasnienkov, Alexander Vaiserman, Denys Vatlitsov
STEM CELLS INTERNATIONAL
(2018)
Review
Cell Biology
Alexander Vaiserman, Alexander Koliada, Oleh Lushchak
AGEING RESEARCH REVIEWS
(2018)
Review
Geriatrics & Gerontology
Veronika Piskovatska, Nadiya Stefanyshyn, Kenneth B. Storey, Alexander M. Vaiserman, Oleh Lushchak
Review
Pharmacology & Pharmacy
Alexander Vaiserman, Alexander Koliada, Oksana Zabuga, Yehoshua Socol
Article
Physiology
Uliana V. Semaniuk, Dmytro V. Gospodaryov, Khrystyna M. Feden'ko, Ihor S. Yurkevych, Alexander M. Vaiserman, Kenneth B. Storey, Stephen J. Simpson, Oleh Lushchak
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Geriatrics & Gerontology
O. V. Lushchak, H. S. Karaman, I. A. Kozeretska, A. K. Koliada, O. G. Zabuga, A. V. Pisaruk, N. M. Koshel, L. V. Mechova, M. V. Inomistova, N. M. Khranovska, A. M. Vaiserman
Review
Geriatrics & Gerontology
Oleh Lushchak, Olha M. Strilbytska, Ihor Yurkevych, Alexander M. Vaiserman, Kenneth B. Storey
EXPERIMENTAL GERONTOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Alexander Vaiserman, Oleh Lushchak
INTERNATIONAL JOURNAL OF GENOMICS
(2019)
Article
Endocrinology & Metabolism
Mykola D. Khalangot, Dmytro S. Krasnienkov, Valentina P. Chizhova, Oleg V. Korkushko, Valery B. Shatilo, Vitaly M. Kukharsky, Victor I. Kravchenko, Volodymyr A. Kovtun, Vitaly G. Guryanov, Alexander M. Vaiserman
FRONTIERS IN ENDOCRINOLOGY
(2019)
Letter
Biochemistry & Molecular Biology
Yehoshua Socol, Yair Y. Shaki, Alexander Vaiserman
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Review
Cell Biology
Carmela Rita Balistreri, Paolo Garagnani, Rosalinda Madonna, Alexander Vaiserman, Gerry Melino
AGEING RESEARCH REVIEWS
(2019)
Article
Cell Biology
Alexander Vaiserman, Oleh Lushchak
AGEING RESEARCH REVIEWS
(2019)