Review
Oncology
Kasra Kolahdouzan, Mohammadreza Chavoshi, Reyhaneh Bayani, Nima Mousavi Darzikolaee
Summary: For COVID-19 patients, whole lung irradiation (WLI) has shown a mild improvement in reducing intubation days but has no significant effect on overall survival. Routine use of WLI for moderate-to-severe COVID-19 patients cannot be recommended based on the current evidence.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Biology
Chi-Jung Tsai, Kang-Wei Chang, Bang-Hung Yang, Ping-Hsiu Wu, Ko-Han Lin, Ching Yee Oliver Wong, Hsin-Lun Lee, Wen-Sheng Huang
Summary: Nuclear medicine is a functional imaging method using radioactive biochemical tracers to evaluate human diseases. However, concerns over radiation emission may lead to neglecting the potential benefits of imaging to patients, highlighting the importance of sound radiation protection concepts.
Article
Oncology
Palak R. Parekh, Eduardo Solano-Gonzalez, Mariana B. Martins, Xinrong Ma, Kayla Tighe, Andrea Casildo, Andrew Zodda, Christopher Johnstone, Yannick Poirier, Javed Mahmood, Kavita Bhalla, Sheri Li, Rena G. Lapidus, France Carrier
Summary: Symptoms of early stomach cancer are often subtle, leading to a high rate of advanced stage diagnosis. Research shows that DUOX2 expression increases the likelihood of preventing cancer dissemination with low dose radiation and chemotherapy. Limited treatment options are available for gastrointestinal cancer patients with disseminated disease.
Review
Oncology
Hamid Ghaznavi
Summary: The study evaluated the effectiveness of low-dose radiation therapy (LDRT) in treating COVID-19 patients, showing an effectiveness rate of up to 90%. The majority of clinical trial investigations on LDRT for COVID-19 found it to be a feasible treatment to improve patient mortality.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Sweety Gupta, Rachit Ahuja, Nidhi Sharma, Pragya Singh, Swati Verma, Manoj Gupta
Summary: The covid-19 pandemic has greatly impacted countries worldwide, with patients often developing respiratory diseases that could progress to SARS-CoV-2 pneumonia. Severe cases of SARS-CoV-2 pneumonia trigger a systemic inflammatory response, but low-dose radiation therapy can help by reducing inflammation and modulating the immune system, thereby easing the burden on healthcare systems.
RESPIRATORY MEDICINE
(2021)
Article
Neurosciences
Kelly Ceyzeriat, Benjamin B. Tournier, Philippe Millet, Giovanna Dipasquale, Nikolaos Koutsouvelis, Giovanni B. Frisoni, Valentina Garibotto, Thomas Zilli
Summary: This study found that low-dose radiation therapy (LD-RT) reduced amyloid load and possibly neuroinflammation markers in early-stage Alzheimer's disease, but did not impact tauopathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Oncology
Xiaolu Yang, Ruonan Wang, Xiaochun Yuan, Shengyu Yao, Chungang Wang, Jinwei Cheng
Summary: This study found that ultra-low-dose radiotherapy is effective in the treatment of ocular adnexal lymphoma, providing excellent local disease control and long-term survival without significant toxicities.
RADIATION ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Freddy Djiepmo, Balint Tamaskovics, Edwin Bolke, Matthias Peiper, Jan Haussmann, Judith Neuwahl, Danny Jazmati, Kitti Maas, Livia Schmidt, Roman Gelzhauser, Christoph Schleich, Stefanie Corradini, Klaus Orth, Martijn van Griensven, Amir Rezazadeh, Kimia Karimi, Wilfried Budach, Christiane Matuschek
Summary: This study evaluated the pain reduction effect of orthovolt or cobalt-based radiation therapy for painful plantar enthesophyte, finding that early integration of radiation therapy in the treatment results in superior pain reduction.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Oncology
Rodrigo Jose Santo, Steven J. M. Habraken, Sebastiaan Breedveld, Mischa S. Hoogeman
Summary: In this study, patient-specific scan patterns were optimized for stereotactic FLASH-PT of early-stage lung cancer and lung metastases. The optimized patterns showed significant improvement in FLASH coverage and potential healthy-tissue sparing compared to standard patterns. The flexibility of the optimizer allows for further fine-tuning based on specific FLASH conditions.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Cell Biology
Ravi B. Patel, Reinier Hernandez, Peter Carlson, Joseph Grudzinski, Amber M. Bates, Justin C. Jagodinsky, Amy Erbe, Ian R. Marsh, Ian Arthur, Eduardo Aluicio-Sarduy, Raghava N. Sriramaneni, Won Jong Jin, Christopher Massey, Alexander L. Rakhmilevich, David Vail, Johnathan W. Engle, Trang Le, Kyung Mann Kim, Bryan Bednarz, Paul M. Sondel, Jamey Weichert, Zachary S. Morris
Summary: The study demonstrates that delivering radiation semiselectively to tumors through targeted radionuclide therapy (TRT) can enhance response to immune checkpoint inhibitors (ICIs), leading to therapeutic efficacy and tumor-specific T cell memory in murine models. Combination of TRT and ICI activates production of proinflammatory cytokines, promotes tumor infiltration by CD8(+) T cells, and reduces metastases, suggesting a promising approach to improve response to ICIs for various tumor types.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jeong Hee Yoon, Jin Young Park, Sang Min Lee, Eun Sun Lee, Jae Hyun Kim, Jeong Min Lee
Summary: This study investigated the effect of reduced iodinated contrast medium (CM) dose on contrast-enhanced liver computed tomography (CT). The results showed that image contrast and overall image quality caused by decreased CM can be restored using low monoenergetic imaging or DL-based iodine-boosting reconstruction.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paula Ibanez, Amaia Villa-Abaunza, Marie Vidal, Pedro Guerra, Sergio Graullera, Carlos Illana, Jose Manuel Udias
Summary: This study presents the implementation of two different dose calculation algorithms based on MC phase-space information on a GPU to calculate dose distributions for the INTRABEAM device quickly and accurately within seconds. The performance study showed that the HMC algorithm is more efficient than the WC-MC algorithm in GPU implementation, achieving dose calculation with noise below 5% in a very short time.
Article
Oncology
Xiao-Yun Li, Dong-Hua Luo, Ling Guo, Hao-Yuan Mo, Rui Sun, Shan-Shan Guo, Li-Ting Liu, Zhen-Chong Yang, Jin-Hao Yang, Fang Qiu, Xue-Song Sun, Pan Wang, Qing Liu, Ji-Bin Li, Qing-Nan Tang, Chao Lin, Qi Yang, Sai-Lan Liu, Yu-Jing Liang, Guo-Dong Jia, Dong-Xiang Wen, Chun-Yan Guo, Jin-Jie Yan, Chong Zhao, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Summary: The study compared the efficacy of two-cycle and three-cycle cisplatin-based chemoradiotherapy in patients with low-risk locally advanced nasopharyngeal carcinoma, showing that the two-cycle treatment was noninferior to the three-cycle treatment in terms of 3-year progression-free survival. However, the three-cycle group experienced more severe toxicities.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Myeongsoo Kim, Ui-Jung Hwang, Kyeongyun Park, Dohyeon Kim, Hak Soo Kim, Sang Hyoun Choi, Jong Hwi Jeong, Dongho Shin, Se Byeong Lee, Joo-Young Kim, Tae Hyun Kim, Hye Jung Baek, Hojin Kim, Kihwan Kim, Sang Soo Kim, Young Kyung Lim
Summary: The study aims to implement proton minibeam radiation therapy (pMBRT) in clinical proton therapy facilities using a multislit collimator (MSC) and a scattering device. Through simulation and experiments, it has been shown that the combination of MSC and scatterers can successfully achieve pMBRT and demonstrate consistent patterns in dose distribution.
Article
Oncology
Fernanda G. Herrera, Catherine Ronet, Maria Ochoa de Olza, David Barras, Isaac Crespo, Massimo Andreatta, Jesus Corria-Osorio, Aodrenn Spill, Fabrizio Benedetti, Raphael Genolet, Angela Orcurto, Martina Imbimbo, Eleonora Ghisoni, Blanca Navarro Rodrigo, Dominik R. Berthold, Apostolos Sarivalasis, Khalil Zaman, Rafael Duran, Clarisse Dromain, John Prior, Niklaus Schaefer, Jean Bourhis, Georgia Dimopoulou, Zoi Tsourti, Marius Messemaker, Thomas Smith, Sarah E. Warren, Periklis Foukas, Sylvie Rusakiewicz, Mikael J. Pittet, Stefan Zimmermann, Christine Sempoux, Urania Dafni, Alexandre Harari, Lana E. Kandalaft, Santiago J. Carmona, Denarda Dangaj Laniti, Melita Irving, George Coukos
Summary: Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Low-dose radiation reprograms the tumor microenvironment to promote T-cell infiltration and, when combined with immunotherapy, simultaneously mobilizes innate and adaptive immunity, predominantly CD4(+) effector T cells, for tumor control dependent on NKG2D. This combination induces important responses in patients with metastatic immune-cold tumors.