Article
Multidisciplinary Sciences
Md Asaduzzaman, Eric Koetz, Hanwen Wu, Michael Hopwood, Adam Shephard
Summary: The study found that glyphosate-resistant plants generally produced more biomass and had higher spike and seed numbers per plant at higher concentrations of glyphosate. However, in the absence of glyphosate, resistant plants performed worse than susceptible plants. The widespread use of glyphosate in fields may favor the selection of resistant individuals.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Soha M. Hussien, Engy R. Rashed
Summary: This study investigated the role of cell-mediated immunological response in the adaptive response induced by low-dose ionizing radiation. The results showed that low-dose ionizing radiation can protect the body against high-dose radiation by suppressing the immune response.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Snehasis Biswas, Jayesh Bellare
Summary: This study found that pretreatment of zebrafish with a sparingly soluble mercury compound can induce adaptive mechanisms that resist the neurotoxic effects of mercury chloride. Biochemical and proteomics studies showed that pretreatment prevents alteration of reactive oxygen species and various protein expressions related to oxidative stress. This research provides new insights for the treatment of mercury toxicity.
Review
Biochemistry & Molecular Biology
Johannes Burtscher, Robert T. Mallet, Vincent Pialoux, Gregoire P. Millet, Martin Burtscher
Summary: In this article, the authors review the current understanding of how the human body adapts to low and high oxygen levels and discuss their potential therapeutic and performance-enhancing applications. They highlight the importance of hypoxia conditioning as a preparation for severe hypoxic insults and the potential benefits of combining it with hyperoxic interventions in the treatment of chronic diseases and for performance enhancement.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Joaquim Sol, Laura Colas-Campas, Gerard Mauri-Capdevila, Jessica Molina-Seguin, Jose Daniel Galo-Licona, Coral Torres-Querol, Nuria Aymerich, Angel Ois, Jaume Roquer, Silvia Tur, Maria del Carmen Garcia-Carreira, Joan Marti-Fabregas, Antonio Cruz-Culebras, Tomas Segura, Reinald Pamplona, Manel Portero-Otin, Gloria Arque, Mariona Jove, Francisco Purroy
Summary: This study provides the first evidence of metabolomics/lipidomic signature related to the development of stroke tolerance in AIS patients induced by recent TIA.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Lijun Wang, Songqing Lai, Xueliang Zhou, Qing Wan, Yong Luo, Huaxi Zou, Qicai Wu, Li Wan, Jichun Liu, Huang Huang
Summary: Ischemic preconditioning and ischemic postconditioning have protective effects on myocardial ischemia/reperfusion injury by alleviating oxidative stress and stabilizing mitochondrial function through the Notch1/Hes1/VDAC1 signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Yupeng Zhang, Shuilian Yang, Jiale Yang, Zhenguo Wu, Hongen Liu, Zhaojun Nie, Jianhua Qu, Yisheng Hu, Yizhen Shao, Jianing Liu, Fengqin Liu, Dangling Hua
Summary: In this study, a novel perspective of hormesis was proposed to explain the temporal hormetic response of soil enzymes and microbes, as well as the variation of soil physicochemical properties. The hormetic response to exogenous Cd was highly generalizable with stimulation of soil enzymatic and microbial activities at a dosage of 0.5 mg•kg-1, but inhibition at higher dosages. However, the response disappeared after incubation for >10 days.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Edward Calabrese, Peter Pressman, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese
Summary: In this review, it is shown that boron induces hormetic dose responses in a wide range of biological models, organ systems, and endpoints. Particularly, hormetic findings have been reported in whole animal studies, suggesting that boron may have significant systemic effects beyond its essential functions. Re-exploring the bioactivity of boron through hormetic mechanisms may contribute to the assessment of micronutrient effects on human health and disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Jason A. Coral, Samuel Heaps, Stephen P. Glaholt, Jonathan A. Karty, Stephen C. Jacobson, Joseph R. Shaw, Maria Bondesson
Summary: This study investigated the bimodal response of arsenic on zebrafish embryos and found distinct bimodal phenotypic effects. Exposure to arsenic at different concentrations led to varying physiological and morphological abnormalities in the embryos. Tests with dechorionated embryos supported the idea that the bimodal toxicity response was not caused by the chorion limiting arsenic availability.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Michael O. Eze, Simon C. George, Grant C. Hose
Summary: Bioassays were conducted on 15 plant species to determine their tolerance to diesel fuel toxicity. Results showed that increasing diesel fuel concentrations generally led to a decrease in biomass in 13 species, while Medicago sativa exhibited a significant hormetic influence. The study highlights the importance of considering hormesis in plant toxicology research.
Article
Plant Sciences
Isabella Bettarini, Cristina Gonnelli, Federico Selvi, Andrea Coppi, Luigia Pazzagli, Ilaria Colzi
Summary: The study found that nickel has a stimulatory effect on plant growth in Odontarrhena populations, and tolerance is positively correlated with nickel accumulation.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Agricultural Engineering
Nengyao Xu, Haibo Li, Tingting Guo, Yanan Hou, Yi Han, Yuanyuan Song, Daohong Zhang, Jianbo Guo
Summary: The impact of ibuprofen (IBU) on the sulfur autotrophic denitrification (SAD) process and microbial toxic response mechanism was investigated. High concentrations of IBU (10 and 50 mg/L) inhibited nitrate removal performance, while low concentration of IBU (1 mg/L) had negligible effect on nitrate removal performance. The low concentration of IBU induced basal oxidative stress for microbial self-protection, while the high concentration of IBU resulted in high-intensity oxidative stress damaging microbial cell membrane structure.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Edward J. Calabrese, Dima Yazji Shamoun, Evgenios Agathokleous
Summary: This paper suggests that the origin of the LNT concept for ionizing radiation was based on a lack of understanding of evolution, leading to the establishment of the linear no threshold dose response model. However, modern advancements in repair mechanisms have shown that the historical foundations of LNT were flawed.
ENVIRONMENTAL POLLUTION
(2022)
Review
Pharmacology & Pharmacy
Edward J. Calabrese, Walter J. Kozumbo
Summary: Nrf2 serves as an adaptive mechanism that can be activated by various oxidative stressors, integrating and enhancing metabolic strategies to produce acquired resilience.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Eduard J. Sanders, Peter Mugo, Henrieke A. B. Prins, Elizabeth Wahome, Alexander N. Thiong'o, Grace Mwashigadi, Elisabeth M. van der Elst, Anisa Omar, Adrian D. Smith, Susan M. Graham
Meeting Abstract
Immunology
Peter M. Mugo, Henrieke Prins, Elizabeth Wahome, Grace Mwashigadi, Alexander Thiong'o, Evanson Gichuru, Anisa Omar, Susan M. Graham, Eduard J. Sanders
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2014)
Article
Multidisciplinary Sciences
Peter M. Mugo, Elizabeth W. Wahome, Evanson N. Gichuru, Grace M. Mwashigadi, Alexander N. Thiong'o, Henrieke A. B. Prins, Tobias F. Rinke de Wit, Susan M. Graham, Eduard J. Sanders
Article
Infectious Diseases
Peter M. Mugo, Henrieke A. B. Prins, Elizabeth W. Wahome, Grace M. Mwashigadi, Alexander N. Thiong'o, Evanson Gichuru, Anisa Omar, Susan M. Graham, Eduard J. Sanders
SEXUALLY TRANSMITTED INFECTIONS
(2015)
Review
Public, Environmental & Occupational Health
Henrieke A. B. Prins, Peter Mugo, Elizabeth Wahome, Grace Mwashigadi, Alexander Thiong'o, Adrian Smith, Eduard J. Sanders, Susan M. Graham
INTERNATIONAL HEALTH
(2014)
Article
Virology
Cynthia Lungu, Francesco A. Procopio, Ronald J. Overmars, Rob J. J. Beerkens, Jolanda J. C. Voermans, Shringar Rao, Henrieke A. B. Prins, Casper Rokx, Giuseppe Pantaleo, David A. M. C. van de Vijver, Tokameh Mahmoudi, Charles A. B. Boucher, Rob A. Gruters, Jeroen J. A. van Kampen
Article
Infectious Diseases
P. D. J. Bollen, H. A. B. Prins, A. Colbers, K. Velthoven-Graafland, B. J. A. Rijnders, T. E. M. S. De Vries-Sluijs, E. van Nood, J. Nouwen, H. Bax, M. de Mendonca Melo, A. Verbon, D. M. Burger, C. Rokx
Summary: This study confirms protein displacement as the main mechanism for the dolutegravir/valproic acid drug-drug interaction, although additional mechanisms might be involved too. If dolutegravir is taken with food, this drug-drug interaction is probably not clinically relevant.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Summary: This study demonstrates the selective induction of cell death in latent HIV-1-infected cells by DDX3 inhibitors, and provides evidence for the reduction of the inducible HIV-1 reservoir in CD4+ T cells from PLWHIV. The pharmacological targeting of DDX3 shows promise in reversing HIV-1 latency and eliminating the latent reservoir.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Immunology
C. Rokx, H. A. B. Prins, L. Vandekerckhove, S. J. Fidler, J. Frater, M. Bracchi, O. S. Sogaard, M. Tolstrop, T. A. Rasmussen, M. Salgado, J. Blanco, J. Martinez-Picado, B. Clotet, G. Tambussi, A. Groenendijk, A. Verbon, C. A. B. Boucher
Summary: The EU2Cure Consortium aims to support research and find a cure for HIV through collaboration in Europe, connecting academia and the community. The focus is on intensifying research collaboration, sharing data, and developing best practices for clinical and translational science to achieve breakthroughs in HIV cure strategies. This strategy should help sustain progress in HIV cure research despite global health or political crises.
JOURNAL OF VIRUS ERADICATION
(2021)
Article
Medicine, General & Internal
Maartje Dijkstra, Henrieke Prins, Jan M. Prins, Peter Reiss, Charles Boucher, Annelies Verbon, Casper Rokx, Godelieve de Bree
Summary: The study focuses on individuals with early HIV infection who start combination antiretroviral therapy (cART) with the aim of investigating the size of the viral reservoir and HIV-specific immune responses in preparation for future HIV cure trials.
Article
Immunology
Henrieke A. B. Prins, Casper Rokx, Annelies Verbon, Ard van Sighem, Godelieve J. de Bree, Maartje Dijkstra, Jan M. Prins, Peter Reiss, Jeroen J. A. van Kampen, David A. M. C. van de Vijver
Summary: Timely identification of acute or early HIV infection is crucial for prevention of onward transmission. This study investigated a sample of individuals with AEHI in the Netherlands and identified transmission clusters, suggesting mainly independent transmission events.
Article
Infectious Diseases
Franziska Badenschier, Anja Berger, Alexandra Dangel, Annika Sprenger, Bernhard Hobmaier, Claudia Sievers, Henrieke Prins, Achim Doerre, Christiane Wagner-Wiening, Wiebe Kuelper-Schiek, Ole Wichmann, Andreas Sing
Article
Infectious Diseases
H. A. B. Prins, L. Zino, E. M. Svensson, A. Verbon, G. J. de Bree, J. M. Prins, P. Reiss, D. M. Burger, C. Rokx, A. Colbers
Summary: This study evaluated the dose adjustment of dolutegravir (DTG) when co-administered with darunavir/ritonavir (DRV/r) in patients with acute human immunodeficiency virus infection (AHI). The results showed that DTG 50 mg twice daily with DRV/r 800/100 mg once daily achieved satisfactory outcomes without significant clinically relevant drug-drug interactions in patients with AHI.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Multidisciplinary Sciences
Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de, Carolina A. M. Schurink, Mariana de Mendonca Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplede, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx
Summary: The BAF complex inhibitor pyrimethamine can reactivate the latent HIV-1 reservoir in people living with HIV-1 (PLWH) on suppressive antiretroviral therapy, but does not lead to a reduction in the size of the inducible reservoir.
Review
Medicine, General & Internal
H. A. B. Prins, A. Verbon, C. A. B. Boucher, C. Rokx
NETHERLANDS JOURNAL OF MEDICINE
(2017)
