期刊
DOMESTIC ANIMAL ENDOCRINOLOGY
卷 40, 期 3, 页码 147-154出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.domaniend.2010.10.001
关键词
Fat metabolism; Heart fatty acid binding protein; Intramuscular fat; Leptin receptor, Pig
The genes coding for H-FABP (heart acid-binding protein) and LEPR (leptin receptor) are considered to be candidates for lipid metabolism and thus affect fat deposition in pigs. The aim of our study was to assess the amount of H-FABP and LEPR transcript in the skeletal muscles (m. longissimus dorsi, m. semimembranosus) and liver of pigs of various ages. The experiments were carried out on 5 popular breeds of swine raised in Poland which exhibit different levels of fat tissue. Furthermore, we examined the effect of H-FABP and LEPR genotypes (HinfI, HpaII, and HaeII for H-FABP and HpaII for LEPR) on the expression abundance of these genes. We confirmed a statistically significant relationship between the breed (P < .001), type of tissue (LEPR P < .001; H-FABP P < .01), and age of the animal (P < .05) on the abundance of mRNA transcript of both genes. In all breeds, the expression of the leptin receptor gene increased significantly (P < .01) with age in muscle tissue, whereas this relationship was not observed in liver tissue. However, the expression of the H-FABP gene in muscles did not change with age or breed, although in the liver expression levels were high in young (60 and 90 d) pigs. In conclusion, H-FABP and LEPR genes are strongly related to the development and function of fat tissue in pigs. (C) 2011 Elsevier Inc. All rights reserved.
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