Review
Chemistry, Analytical
Cigdem Kip, Kadriye Ozlem Hamaloglu, Cihan Demir, Ali Tuncel
Summary: Isolation or enrichment of biological molecules from complex biological samples is often a prerequisite in proteomics, genomics, and glycomics. Among various techniques, bioaffinity chromatography stands out as a powerful method for isolating target biological molecules through specific interactions with ligands immobilized on support materials. Recent developments in bioaffinity chromatography, including properties of supports, immobilization techniques, types of binding agents, and application methods, have been summarized in the literature.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Di Zhang, Bingjian Zhang, Longguan Zhu
Summary: Shellac, a resin composed mainly of aleuritic acid, is used for various applications due to its unique properties. In this study, specific anti-aleuritic acid polyclonal antibodies were prepared and successfully applied for the identification of shellac in traditional mortars. This study presents a novel method for archaeological research using immunological technology.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Immunology
Robert M. F. van der Put, Bernard Metz, Roland J. Pieters
Summary: Glycoconjugate vaccines have shown their value in preventing infectious diseases, with the Haemophilus influenzae type b vaccine being the best example. These vaccines consist of carrier proteins and carbohydrate antigens. Current carrier proteins include tetanus toxoid, diphtheria toxoid, CRM197, Haemophilus protein D, and the outer membrane protein complex of serogroup B meningococcus. Carbohydrate antigens are mainly produced by extraction and purification, but recent advancements have been made in the synthesis of oligosaccharides and bioconjugation.
Article
Chemistry, Analytical
Bert Vankeerberghen, Francois Parmentier, Gert Desmet
Summary: The efficiency of liquid chromatography separations can be greatly improved by using a bundle of parallel capillary tubes instead of packed bed columns. However, the presence of polydispersity caused by small differences in capillary diameter ruins this potential. The concept of diffusional bridging that introduces a cross talk between adjacent capillaries has been proposed to solve this issue, and this study provides the first experimental proof and validation of the theory behind it. The observed reduction in dispersion aligns well with theoretical predictions, suggesting that this theory could lead to the design of a new generation of chromatographic beds with unprecedented performance.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yue Sun, Yu Liang, Chao Wang, Baofeng Zhao, Zhen Liang, Xiaodan Zhang, Yukui Zhang, Lihua Zhang
Summary: Comprehensive characterization of membrane proteins at the level of proteoforms in complex biological samples by top-down mass spectrometry (MS) is of vital importance in revealing their precise functions. However, severe peak broadening in the separation of hydrophobic membrane proteins, caused by resistance to mass transfer and strong adsorption on separation materials, leads to MS spectra overlap and signal suppression, which makes against the in-depth research on membrane proteoforms.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hye Hyeon Han, Homan Kang, Seong-Jong Kim, Rahul Pal, Anand T. N. Kumar, Hak Soo Choi, Sei Kwang Hahn
Summary: Despite extensive research on molecular imaging contrast agents, there are still unmet medical needs for enhancing their signal-to-background ratio, brightness, photostability, and biocompatibility. This study assessed the feasibility of using fluorescent nanodiamonds (FNDs) as carbon-based photostable and biocompatible materials for molecular imaging applications. The results demonstrated the promising potential of HA-FND conjugates for targeted molecular imaging, especially in liver-targeted imaging.
Article
Biotechnology & Applied Microbiology
Natalia Gonzalez-Pech, Anna L. Molloy, Alexandra Zambrano, Wayne Lin, Arash Bohloul, Rafael Zarate-Araiza, Carolina Avendano, Vicki L. Colvin
Summary: This study compares the use of commercial iron-oxide nanoparticles (IONPs) with proven arsenic sorbents for arsenic remediation. The results showed that some commercial sorbents can effectively treat water contaminated with arsenic, but the cost of treatment and waste generation pose challenges for developing countries.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Simon L. Rossler, Nathalie M. Grob, Stephen L. Buchwald, Bradley L. Pentelute
Summary: This study establishes abiotic peptides as carriers of information for the encoding of small-molecule synthesis. These peptides are used to encode diverse small-molecule synthesis and successfully discover protein ligands. This work demonstrates the potential for abiotic peptides in accelerating the discovery of therapeutic targets.
Article
Chemistry, Analytical
Jakub Erben, Marketa Klicova, Andrea Klapstova, Martina Hakova, Ivona Lhotska, Slavomira Zatrochova, Dalibor Satinsky, Jiri Chvojka
Summary: The study focused on utilizing alternating current electrospinning method to produce nanofibrous materials for extraction, demonstrating superior stability and extraction efficiency. The novel material showed excellent performance in high-pressure flow systems, achieving high repeatability, extraction efficiency, and detection limits.
MICROCHEMICAL JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Monica Moreno-Gonzalez, Pattra Chuekitkumchorn, Marcelo Silva, Roos Groenewoud, Marcel Ottens
Summary: This study presents a rational methodology using high throughput experimentation for the separation of major proteins in canola meal, resulting in a very good agreement between theoretical model and experimental results. The study identified column operating parameters that lead to >98% yield and purity for both proteins, paving the way for a conceptual downstream processing proposal.
FOOD AND BIOPRODUCTS PROCESSING
(2021)
Article
Environmental Sciences
Leroy Gonez-Rodriguez, Alexander Johs, Kenneth A. Lowe, Kimberly E. Carter, Frank E. Loffler, Melanie A. Mayes
Summary: Mercury (Hg) as a global environmental pollutant poses a significant risk to human health by threatening water resources. Sorbents like Thiol-SAMMS showed the highest removal rate of Hg in comparison to other sorbents, but none were able to completely remove all introduced Hg. Overall, sorbents demonstrated substantial effectiveness in removing Hg, indicating potential for deployment in contaminated environments, but further optimization is needed to increase efficiency.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Shicong Jia, Ruizhi Tang, Shuai Zhang, Zheng Gao, Bolin Gong, Shujuan Ma, Junjie Ou
Summary: A kind of core-shell composite microsphere with nano-on-micro structure was synthesized via grafting amine-modified nanodiamonds onto the surface of monodisperse nonporous polymeric microsphere. The resulting microsphere showed high efficiency and specificity in enriching phosphopeptides, and could be reused due to the strong chelation between titanium ions and pyrogallol ligands.
Article
Engineering, Environmental
Bethany A. Parker, Detlef R. U. Knappe, Ivan A. Titaley, Thomas A. Wanzek, Jennifer A. Field
Summary: The study investigates the electrostatic interactions between PFAS and an aminopropyl AE phase, and finds that the average electrostatic potential is positively correlated with the PFAS chromatographic retention time. However, electrostatic interactions alone cannot fully explain the affinity of PFAS for AE resins in water treatment/remediation scenarios.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Maham Akhtar Nagra, Natasha Natasha, Irshad Bibi, Tasveer Zahra Tariq, Rabia Naz, Sabah Ansar, Muhammad Shahid, Behzad Murtaza, Muhammad Imran, Muhammad Shafique Khalid, Nasir Masood, Ghulam Mustafa Shah, Nabeel Khan Niazi, Camille Dumat
Summary: Water contamination by arsenic is a serious global health threat. In this study, three biosorbents (tea waste, wheat straw, and peanut shells) were evaluated for their efficiency in removing arsenic from water samples. The results showed that all three biosorbents effectively removed arsenic, with tea waste biosorbent being the most efficient. The risk parameters were significantly decreased after arsenic removal, indicating a reduction in health risks. The synthesized biosorbents showed potential for eco-friendly arsenic removal.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Energy & Fuels
M. de las Obras Loscertales, A. Abad, F. Garcia-Labiano, L. F. de Diego, P. Gayan, J. Adanez
Summary: Four different physico-chemical characteristics of Ca-based sorbents were evaluated as suitable precursors for CaSO4-based oxygen carriers in CLC systems.