期刊
DNA REPAIR
卷 17, 期 -, 页码 30-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2014.02.019
关键词
Non-homologous end joining; Ku; Double-strand break; APLF; WRN
资金
- Cancer Research UK [16771, 13078] Funding Source: researchfish
- Cancer Research UK [13078] Funding Source: Medline
The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal structure that allows the protein to slide over the broken DNA end and bind with high affinity. Once locked into placed, Ku acts as a tool-belt to recruit multiple interacting proteins, forming one or more non-homologous end joining complexes that act in a regulated manner to ensure efficient repair of DNA ends. Here we review the structure and functions of Ku and the proteins with which it interacts during non-homologous end joining. (C) 2014 Elsevier B.V. All rights reserved.
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