Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Review
Chemistry, Physical
Daan Zillen, Max Beugeling, Wouter L. J. Hinrichs, Henderik W. Frijlink, Floris Grasmeijer
Summary: Pulmonary drug delivery using dry powder formulations offers advantages such as improved dosing reproducibility and aerosolization performance. However, the pulmonary toxicity of many of the excipients used in these formulations remains largely unknown and requires further research attention.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yuqing Ye, Ying Ma, Jesse Zhu
Summary: Dry powder inhalation therapy has been proven effective in the treatment of respiratory diseases and has gained wide acceptance in clinical practices. There is growing interest in using this therapy for systemic diseases, including its potential application in COVID-19 treatment. This paper reviews the current status of marketed and in-development dry powder inhalers for systemic diseases and summarizes the advancements and challenges in DPI systems. It concludes that dry powder inhalation therapy holds great potential and promise for the treatment of systemic disorders.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Sakurako Tajiri, Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Kohichiro Asano
Summary: The study found that inhalation flow profiles measured in real-world settings differ from those measured in the laboratory, showing weaker and shorter characteristics. The results emphasize the importance of rapid inhalation when using a dry powder inhaler.
RESPIRATORY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Anne Haaije de Boer, Paul Hagedoorn, Floris Grasmeijer
Summary: In this article, examples of ancient inhalation therapy and the development of early dry powder inhalers are discussed. The use of databases and personal communication with historians and custodians of historic manuscripts and artifacts were used to verify information. The article suggests that inhalation therapy may have a longer and more widespread history than currently known.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Anna Lechanteur, Erwan Plougonven, Luisa Orozco, Geoffroy Lumay, Nicolas Vandewalle, Angelique Leonard, Brigitte Evrard
Summary: In this study, engineered inhalation powders were developed using the spray-drying technique, combining multiple carbohydrates excipients with two active pharmaceutical ingredients for asthma therapy. By adjusting the excipients, the morphology of inhalable powders could be finely tuned, leading to stable inhalation powders that induced high fine particle fractions for two drugs. The stability of these powders has been evaluated for up to 2 months at room temperature.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Mohammad Zaidur Rahman Sabuj, Md Abdur Rashid, Tim R. Dargaville, Nazrul Islam
Summary: This study investigated the stability of CIP-loaded polymer nanoparticles under normal and high stressed conditions, finding that high temperature and humidity led to changes in particle size, surface quality, and reduced aerosol performance.
Review
Medicine, Research & Experimental
Hao Lou, Li Ding, Tian Wu, Weikun Li, Ryan Khalaf, Hugh D. C. Smyth, Darren L. Reid
Summary: This review provides an overview of the critical process parameters in the manufacturing of dry powder inhaler (DPI) products and discusses the application of models and simulations in DPI process development. The authors emphasize the increasing importance of models and simulations in evaluating the impact of material attributes and process parameters on process performance, and expect that advancements in computational power will enable more accurate modeling and simulation of real-world DPI process operations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Md Abdur Rashid, Saiqa Muneer, Jayanti Mendhi, Mohammad Zaidur Rahman Sabuj, Yahya Alhamhoom, Yin Xiao, Tony Wang, Emad L. Izake, Nazrul Islam
Summary: In this study, a dry powder inhaler (DPI) formulation of edoxaban (EDX) was developed and characterized, demonstrating promising in-vitro anticoagulation effect for managing pulmonary or cerebral coagulopathy associated with COVID-19 infection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Bishal Raj Adhikari, Shyamal C. Das
Summary: This study investigated the aerosol performance of spray-dried powders based on Soluplus polymer for pulmonary drug delivery. The potential use of leucine to improve aerosolization was also explored. The results showed that Soluplus powder without leucine exhibited good performance for pulmonary drug delivery, and the addition of 20% leucine further enhanced aerosolization of the particles.
Article
Pharmacology & Pharmacy
Hana Douafer, Veronique Andrieu, Emmanuel Wafo, Michelle Sergent, Jean Michel Brunel
Summary: The global increase of multidrug resistant bacteria and the lack of new classes of antibiotics are challenging clinicians in treating bacterial infections. A new adjuvant has been identified to enhance antibiotic activity against resistant P. aeruginosa strains. An experimental protocol was developed to optimize a dry powder for inhalation delivering antibiotic and adjuvant simultaneously.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Alexander Welle, Mohit Mehta, Karin Marek, Harry Peters, Peter Van der Wel, Olukayode Imole
Summary: This study investigated the impact of high shear blending conditions on the distribution of magnesium stearate on lactose particles. The results showed that magnesium stearate significantly affected the rheological properties of the blends, and blending speed had a strong influence on the distribution of magnesium stearate on lactose surface, while blending time had a minor effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Aljoscha Gabelmann, Claus-Michael Lehr, Holger Grohganz
Summary: Addressing antimicrobial resistance requires new approaches in various disciplines of pharmaceutical sciences. The fluoroquinolone levofloxacin (LEV) plays an important role in the therapy of lung infections. However, its effectiveness is limited by its severe side effects involving tendinopathy, muscle weakness and psychiatric disturbance. Therefore, there is a need for the development of an effective formulation of LEV with reduced systemic drug concentrations, thereby also reducing the consumption and excretion of antibiotics or metabolites.
Article
Pharmacology & Pharmacy
Zitong Shao, Waiting Tai, Yingshan Qiu, Rico C. H. Man, Qiuying Liao, Michael Y. T. Chow, Philip C. L. Kwok, Jenny K. W. Lam
Summary: This study developed an inhaled dry powder formulation of capreomycin targeting the lung using spray drying technique, showing promising pharmacokinetic performance with sustained drug concentration in the lungs. Compared to intravenous injection, inhaled capreomycin exhibited superior pharmacokinetics in both the lungs and plasma, indicating its potential as a more effective treatment option for MDR-TB.
Article
Pharmacology & Pharmacy
Fabio Sonvico, Veronica Chierici, Giada Varacca, Eride Quarta, Davide D'Angelo, Ben Forbes, Francesca Buttini
Summary: The newly developed RespiCell (TM) dissolution apparatus is suitable for testing the dissolution of active pharmaceutical ingredients in pulmonary products, aiding in the study of particle dissolution rate and providing significant data for product quality and efficacy.