☆ 4.3 Article

Defining the DNA mismatch repair-dependent apoptotic pathway in primary cells: Evidence for p53-independence and involvement of centrosomal caspase 2

DNA REPAIR (2010)

期刊

DNA REPAIR

卷 9, 期 2, 页码 161-168

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.dnarep.2009.11.010

关键词

DNA mismatch repair; Msh6; UVB; Apoptosis; p53; Caspase 2; Centrosome

类别

Genetics & Heredity Toxicology

资金

Canadian Institutes of Health Research
National Cancer Institute of Canada
Alberta Heritage Foundation

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Protocol

Reagent

摘要

Many studies have shown that DNA mismatch repair (MMR) has a role beyond that of repair in response to several types of DNA damage, including ultraviolet radiation (UV). We have demonstrated previously that the MMR-dependent component of UVB-induced apoptosis is integral to the suppression of UVB-induced tumorigenesis. Here we demonstrate that Msh6-dependent UVB-induced apoptotic pathway is both activated via the mitochondria and p53-independent. In addition, we have shown for the first time that caspase 2, an initiator caspase, localizes to the centrosomes in mitotic primary mouse embryonic fibroblasts, irrespective of MMR status and UVB treatment. (C) 2009 Elsevier B.V. All rights reserved.

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