期刊
DNA REPAIR
卷 8, 期 4, 页码 491-498出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2009.01.002
关键词
SUMO; p53 family; p63; p73; Ubiquitin
资金
- Deutsche Forschungsgemeinschaft
- German Israeli Foundation for Development and Scientific Research
- Max-Planck Society
p53 and its cousins p63 and p73 are critical regulators of the genotoxic stress response in mammalian cells. Their activity is controlled by an intricate network of post-translational modifications. The ubiquitin-like SUMO system targets all three family members and modulates their transcriptional activity, stability or subcellular trafficking. While the SUMO system appears to primarily exert a negative regulatory function on p73 and p63, both activating and repressing activities have been reported on p53. Here we will give a synopsis of the multifaceted effects of SUMO on p53 family members. (C) 2009 Elsevier B.V. All rights reserved.
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