期刊
DNA REPAIR
卷 8, 期 1, 页码 137-141出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2008.09.006
关键词
Somatic hypermutation; Mutation analysis; Standardization
资金
- The Seaver Foundation Center for Bioinformatics
- NIH [1-R01-AG028872, 1-P01-AG027734]
- Spanish Ministry of Education and Science [EX-2006-0732]
- National Women's Division of the Albert Einstein College of Medicine [RO1CA72649, R01CA102705]
- NATIONAL CANCER INSTITUTE [R01CA072649, R01CA102705] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG028872, P01AG027734] Funding Source: NIH RePORTER
The somatic hypermutation (SHM) of Immunoglobulin variable (V) regions is a key process in the generation of antibody diversity. The growing number of datasets of point mutations that occur during SHM in mice and humans often include comparisons between wild-type and individuals or strains genetically defective in the repair mechanisms that contribute to SHM. However, it has been difficult to compare the results of different studies because the analyses have not been standardized for criteria such as correction for base composition and the inclusion of unique Mutations. If many mutations are involved, the analysis can also be time consuming. To overcome these problems and facilitate a standardized analysis and display of similar data, we present a webserver (SHMTool) for comparing SHM datasets, available at http://scb.aecom.yu.edu/shmtool. (C) 2008 Elsevier B.V. All rights reserved.
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