期刊
DNA REPAIR
卷 8, 期 9, 页码 1089-1100出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2009.04.010
关键词
Replication; Checkpoint; Histone modification; Repair; Chromatin remodeling
资金
- University of Geneva
- SNF NCCR Frontiers in Genetics
- Novartis Research Foundation
DNA damage during replication requires an integration of checkpoint response with replication itself and distinct repair pathways, such as replication pausing. recombination and translesion synthesis. Here we focus on recent advances in our understanding of how protein posttranslational modifications contribute to the maintenance of fork integrity. in particular, we examine the role of histone modifications and chromatin remodeling complexes in this process. (C) 2009 Elsevier B.V. All rights reserved.
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