期刊
DNA REPAIR
卷 8, 期 9, 页码 1025-1037出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2009.04.015
关键词
Xenopus laevis; DNA damage response; Genome stability; Cell cycle; DNA repair
资金
- Cancer Research UK
- Lister Institute for Preventive Medicine
- EMBO Yip program
- European Research Council (ERC)
Exogenous and endogenous insults continuously damage DNA. DNA damage must be detected in order to prevent loss of vital genetic information. Cells respond to DNA damage by activating checkpoint pathways that delay the progression through the cell cycle, promote DNA repair or induce cell death. A regulatory network of proteins has been identified that participate in DNA damage checkpoint pathways. Central to this network are ATM, ATR and the Mre11/Rad50/Nbs1 (MRN) complex. Detailed biochemical analysis of ATM, ATR and the MRN dependent DNA damage responses has taken advantage of several in vitro model systems to understand the detailed mechanisms underlying their function. Here we describe some recent findings obtained analysing these pathways using in vitro model systems. In particular we focus on the studies performed in the Xenopus laevis egg cell free extract, which recapitulates the DNA damage response in the context of the cell cycle. (C) 2009 Elsevier B.V. All rights reserved.
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