期刊
DNA AND CELL BIOLOGY
卷 33, 期 10, 页码 705-714出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2014.2432
关键词
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资金
- National Natural Science Foundation of China [31370904, 30972691]
- Shanghai Science and Technology Development Funds [10QA1405900]
- Training Program of the Excellent Young Talents of the Shanghai Municipal Health System [XYQ20110115]
- Shanghai Municipal Science and Technology Foundation [11JC1410802]
- Shanghai health system important disease joint research project - key projects [2013ZYJB0004]
Interleukin (IL)-22, a relatively new member of the IL-10 family, has been implicated in inflammation and tumorigenesis. The aim of this study was to identify genetic polymorphisms in IL-22 and to measure plasma levels of IL-22 in patients with nonsmall cell lung cancer (NSCLC). Patients with NSCLC had a significantly higher frequency of IL-22 rs2227484 CT genotype (odds ratio [OR] = 1.917, 95% confidence interval [CI] 1.001-3.670, p = 0.038) and T allele (OR = 1.878, 95% CI 1.010-3.491, p = 0.049) as compared with controls. The rs2227484 genotype was associated with a 2.263-fold increased risk for advanced NSCLC (p = 0.041). Among different subtypes of NSCLC, these associations were more obvious in the adenocarcinoma. Moreover, patients with high frequencies of genotypic polymorphisms had high plasma levels of IL-22. IL-22 polymorphisms and corresponding high levels of IL-22 in plasma may contribute to the development of NSCLC, especially adenocarcinoma.
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