期刊
DNA AND CELL BIOLOGY
卷 32, 期 11, 页码 622-627出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2013.2172
关键词
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资金
- National Institute of General Medical Sciences (NIGMS) [R01GM086530-01]
- Marion Bessin Liver Center Imaging and Cell Structure Core
- National Institute of Diabetes and Digestive and Kidney Diseases NIDDK [2P30DK041296]
- NIH Training Program in Cellular and Molecular Biology and Genetics [T32 GM007491]
Fluorescent proteins (FPs) have been powerful tools for cell biologists for over 15 years. The large variety of FPs available rarely comes with an instruction manual or a warning label. The potential pitfalls of the use of FPs in cellular organelles represent a significant concern for investigators. FPs generally did not evolve in the often distinctive physicochemical environments of subcellular organelles. In organelles, FPs can misfold, go dark, and even distort organelle morphology. In this minireview, we describe the issues associated with FPs in organelles and provide solutions to enable investigators to better exploit FP technology in cells.
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