In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
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关键词
daphnetin, glucuronidation, methyl substitution, structural modification, metabolic stability, phase II enzymes, glucuronosyl-transferases, human liver microsomes, enzyme kinetics, metabolic clearance
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