Article
Oncology
Mees Hendrik Siert de Jong, Suzanne Sarah Gisbertz, Mark Ivo van Berge Henegouwen, Werner Adriaan Draaisma
Summary: The study supports the Japanese Gastric Cancer Guideline that D1 lymphadenectomy is sufficient for early gastric cancer and D2 lymphadenectomy should be performed for advanced gastric cancer.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Computer Science, Information Systems
Lu Wang, Tian Song, Takafumi Katayama, Xiantao Jiang, Takashi Shimamoto, Jenq-Shiou Leu
Summary: An innovative deep regional metastases segmentation framework is proposed for patient-level classification of lymph node metastasis in breast cancer patients. The framework combines deep segmentation network and density-based spatial clustering algorithm to provide consistent and accurate metastasis diagnosis in histological lymph node section images.
Article
Oncology
Canhua Yun, Juan Xiao, Jingjia Cao, Chunchun Shao, Lihua Wang, Wei Zhang, Hongying Jia
Summary: The study analyzed 1228 patients who received RAI treatment and found that LNMs and LNR are important predictors for initial response to RAI, with optimal cutoff values of 5 and 0.30, respectively.
Review
Multidisciplinary Sciences
Cancan Chen, Shan Zheng, Lei Guo, Xuebing Yang, Yan Song, Zhuo Li, Yanwu Zhu, Xiaoqi Liu, Qingzhuang Li, Huijuan Zhang, Ning Feng, Zuxuan Zhao, Tinglin Qiu, Jun Du, Qiang Guo, Wensheng Zhang, Wenzhao Shi, Jianhui Ma, Fenglong Sun
Summary: This study proposes a method using relative risk classification and regression tree to identify misdiagnosed whole-slide images of breast cancer lymph node metastasis and recommend them for review by pathologists. The results show an average accuracy of 0.9851, but a significantly higher misdiagnosis rate compared to pathologists. It is also found that most misdiagnoses from DNN models belong to a low-accuracy group.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Amy Jamieson, Emily F. Thompson, Jutta Huvila, Samuel Leung, Amy Lum, Chantale Morin, Kaoutar Ennour-Idrissi, Alexandra Sebastianelli, Marie-Claude Renaud, Jean Gregoire, David G. Huntsman, C. Blake Gilks, Marie Plante, Katherine Grondin, Jessica N. McAlpine
Summary: This study assessed the association between molecular subtypes and lymph node metastases in endometrial cancer patients. The results showed a significant association between molecular subtypes and lymph node metastases. This information can be used to guide surgical treatment planning and reduce unnecessary lymph node staging.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Kosmas Daskalakis, Maria Wedin, Marina Tsoli, Angelika Kogut, Raj Srirajaskanthan, Konstantinos Sarras, Sajith Kattiparambil, George Giovos, Martin O. O. Weickert, Beata Kos-Kudla, Gregory Kaltsas
Summary: The prognostic impact of tumor- and patient-related parameters in stage I-III small intestinal neuroendocrine tumors (SI-NETs) after locoregional resective surgery (LRS) was assessed. The study found that several factors, including lymph node metastases, tumor grade, and Ki-67 proliferation index, were associated with recurrence-free survival (RFS). It highlights the importance of meticulous lymph node dissection and control of the number of retrieved lymph nodes in the surgical management of SI-NET patients.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Bo Chen, Guochun Zhang, Jianguo Lai, Weikai Xiao, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao
Summary: This study revealed significant differences in molecular and immune profiles between single lymph node metastases and multiple lymph node metastases in breast cancer patients. Single lymph node metastases were associated with more aggressive tumor characteristics and more favorable immune characteristics compared to multiple lymph node metastases.
Article
Oncology
Jun Wang, Qianying Liu, Haotian Xie, Zhaogang Yang, Hefeng Zhou
Summary: The study aimed to enhance EfficientNet's performance by developing a cropping method (RCC) to retain original image resolution and significant features, reducing downsampling scale to fit small resolution images in RPCam datasets, and integrating attention and feature fusion mechanisms to extract features with rich semantic information. Experiments showed significant performance improvement, with the best method achieving 97.96% accuracy and 99.68% AUC on RPCam datasets.
Article
Urology & Nephrology
Berdine L. Heesterman, Henk G. van der Poel, Ivo G. Schoots, Niven Mehra, Katja K. H. Aben
Summary: This study evaluated the prognostic importance of concomitant non-regional lymph node and bone metastases in men with synchronous metastatic hormone-sensitive prostate cancer. It found that in low-volume disease, the presence of these metastases was a poor prognostic sign, while survival was worse for men with visceral metastases. This implies a need to reconsider the classification of metastatic burden.
Article
Oncology
Yan Li, Alexander J. Byun, Jennie K. Choe, Shaohua Lu, David Restle, Takashi Eguchi, Kay See Tan, Jasmeen Saini, James Huang, Gaetano Rocco, David R. Jones, William D. Travis, Prasad S. Adusumilli
Summary: The presence of micropapillary and solid histologic patterns in lymph node metastases is associated with worse outcomes in patients with advanced nonmucinous lung adenocarcinoma. The presence of micropapillary and solid patterns is associated with a higher incidence of smoking history, tumor necrosis, and tumor spread through air spaces, as well as a higher prevalence of micropapillary or solid patterns in the primary tumor. These histologic patterns are independently associated with shorter overall survival, higher lung cancer-specific cumulative incidence of death, and higher cumulative incidence of recurrence.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Surgery
A. L. Ebbehoj, L. N. Jorgensen, P-M Krarup, H. G. Smith
Summary: This study reviewed the association between histopathological findings and lymph node metastases in T1 colorectal cancer, finding that factors such as lymphovascular invasion, tumor budding, and depth of submucosal invasion were associated with LNMs. These distinct histopathological factors can help in selecting patients for local excision or major excisional surgery.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Doris Mangiaracina Benbrook, James Randolph Sanders Hocker, Katherine Marie Moxley, Jay S. Hanas
Summary: This study analyzed serum samples from endometrial cancer patients and benign gynecology surgical patients using electron spray ionization mass spectrometry (ES-MS), and evaluated the differences in serum proteins through leave one out cross validation (LOOCV). The study found that serum proteins could distinguish between different groups and predict positive lymph node metastases. Pathways related to metastases include loss of PTEN activation, calcium signaling activation, and estrogen receptor-induced transcription. These findings provide new insights for treatment decisions in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Alexander Harris, James Butterworth, Piers R. Boshier, Hugh MacKenzie, Masanori Tokunaga, Hideki Sunagawa, Stella Mavroveli, Melody Ni, Sameh Mikhail, Chi-Chuan Yeh, Natalie S. Blencowe, Kerry N. L. Avery, Richard Hardwick, Arnulf Hoelscher, Manuel Pera, Giovanni Zaninotto, Simon Law, Donald E. Low, Jan J. B. van Lanschot, Richard Berrisford, Christopher Paul Barham, Jane M. Blazeby, George B. Hanna
Summary: A reliable surgical quality assurance system for 2-stage esophagectomy has been developed, which includes an operation manual, video, and photographic assessment tools. It aims to ensure surgical quality in surgical oncology randomized controlled trials.
Article
Surgery
Bram D. Vermeulen, Britt van der Leeden, Jawad T. Ali, Tomas Gudbjartsson, Michael Hermansson, Donald E. Low, Douglas G. Adler, Abraham J. Botha, Xavier B. D'Journo, Atila Eroglu, Lorenzo E. Ferri, Christoph Gubler, Jan Willem Haveman, Lileswar Kaman, Richard A. Kozarek, Simon Law, Gunnar Loske, Joerg Lindenmann, Jung-Hoon Park, J. David Richardson, Paulina Salminen, Ho-Yong Song, Jon A. Soreide, Manon C. W. Spaander, Jeffrey N. Tarascio, Jon A. Tsai, Tim Vanuytsel, Camiel Rosman, Peter D. Siersema
Summary: This study found that early diagnosis (≤ 24 h) compared to late diagnosis (> 24 h) in benign esophageal perforations, particularly in IEP patients, is associated with improved clinical outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Hin Chu, Jasper Fuk-Woo Chan, Yixin Wang, Terrence Tsz-Tai Yuen, Yue Chai, Huiping Shuai, Dong Yang, Bingjie Hu, Xiner Huang, Xi Zhang, Yuxin Hou, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivan Fan-Ngai Hung, Tan To Cheung, Ada Tsui-Lin Ng, Ivy Hau-Yee Chan, Ian Yu-Hong Wong, Simon Ying-Kit Law, Dominic Chi-Chung Foo, Wai-Keung Leung, Kwok-Yung Yuen
Summary: The study found that SARS-CoV-2 could infect and replicate in human intestinal tissues ex vivo, but not in liver and kidney tissues. SARS-CoV-2 replicated less efficiently than SARS-CoV in human intestinal tissues, causing less cytopathology and inducing a more robust innate immune response.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Bofei Li, Ka Shing Cheung, Ian Yu-Hong Wong, Wai Keung Leung, Simon Law
Summary: The study found that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) did not reduce the risk of gastric cancer in patients who underwent Helicobacter pylori eradication, suggesting that the chemopreventive effect of NA-NSAIDs observed in prior studies may have been confounded by immortal time bias.
Review
Medicine, Research & Experimental
Bilal Alkhaffaf, Jane M. Blazeby, Aleksandra Metryka, Anne-Marie Glenny, Ademola Adeyeye, Paulo Matos Costa, Ismael Diez del Val, Suzanne S. Gisbertz, Ali Guner, Simon Law, Hyuk-Joon Lee, Ziyu Li, Koji Nakada, Rafael Mauricio Restrepo Nunez, Daniel Reim, John V. Reynolds, Peter Vorwald, Daniela Zanotti, William Allum, M. Asif Chaudry, Ewen Griffiths, Paula R. Williamson, Iain A. Bruce
Summary: Through a comprehensive review of current approaches to translating Delphi surveys for COS development, it was found that there is wide variation in methodological approaches to translation, including the number of forward translations, the inclusion of back translation, cognitive debriefing, and handling discrepancies and disagreements. Important considerations were identified during the development of the gastric cancer survey including establishing translation groups, timelines, understanding financial implications, strategies to maximize recruitment, and regulatory approvals.
Article
Surgery
Xavier Benoit D'Journo, David Boulate, Alex Fourdrain, Anderson Loundou, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz, J. Robert O'Neill, Arnulf Hoelscher, Guillaume Piessen, Jan van Lanschot, Bas Wijnhoven, Blair Jobe, Andrew Davies, Paul M. Schneider, Manuel Pera, Magnus Nilsson, Philippe Nafteux, Yuko Kitagawa, Christopher R. Morse, Wayne Hofstetter, Daniela Molena, Jimmy Bok-Yan So, Arul Immanuel, Simon L. Parsons, Michael Hareskov Larsen, James P. Dolan, Stephanie G. Wood, Nick Maynard, Mark Smithers, Sonia Puig, Simon Law, Ian Wong, Andrew Kennedy, Wang KangNing, John V. Reynolds, C. S. Pramesh, Mark Ferguson, Gail Darling, Wolfgang Schroder, Marc Bludau, Tim Underwood, Richard van Hillegersberg, Andrew Chang, Ivan Cecconello, Ulysses Ribeiro, Giovanni de Manzoni, Riccardo Rosati, MadhanKumar Kuppusamy, Pascal Alexandre Thomas, Donald E. Low
Summary: The study developed a risk prediction model for 90-day mortality after esophagectomy based on large data sets, which can aid in individual patient risk assessment. The model, supported by analyses of preoperative variables, is suggested to be useful in decision-making and informed consent for esophageal cancer surgery.
Article
Peripheral Vascular Disease
Ngar Woon Kam, Ka Chun Wu, Wei Dai, Ying Wang, Leo Yik Chun Yan, Reshma Shakya, Rajiv Khanna, Yanru Qin, Simon Law, Anthony Wing Ip Lo, Victor Ho Fun Lee, Xin-Yuan Guan, Dora Lai-Wan Kwong
Summary: Different functions and profiles of B-cell subsets in various cancers have been reported. In esophageal squamous cell carcinoma (ESCC), proliferating B cells are predominantly found in the peritumoral region with high expression of HMGB1. Cancer-derived HMGB1 modulates B cells to promote angiogenesis in ESCC microenvironment.
Article
Oncology
Matthieu Faron, Armel Maurice Cheugoua-Zanetsie, Pierre Thirion, Matthew Nankivell, Kathryn Winter, David Cunningham, Ate Van der Gaast, Simon Law, Ruth Langley, Florent de Vathaire, Michele Valmasoni, Muriel Mauer, Jack Roth, Val Gebski, Bryan H. Burmeister, Xavier Paoletti, Johanna van Sandick, Jianhua Fu, Michel Ducreux, Pierre Blanchard, Jayne Tierney, Jean-Pierre Pignon, Stefan Michiels
Summary: This study investigated the effect of neoadjuvant chemotherapy on overall survival in patients with locally advanced thoracic oesophagus or gastro-oesophageal junction carcinoma undergoing surgery. The results showed that neoadjuvant chemotherapy had a significantly better overall survival compared to surgery alone, with a more pronounced effect in patients with gastro-oesophageal junction carcinoma.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Bilal Alkhaffaf, Aleksandra Metryka, Jane M. Blazeby, Anne-Marie Glenny, Paula R. Williamson, Iain A. Bruce
Summary: Our study indicates that there is little variation in opinion within stakeholder groups when participant region and other characteristics are considered. This finding may assist COS developers in designing their Delphi surveys and recruitment strategies. Further research in other clinical fields is needed before broader recommendations can be made.
Article
Gastroenterology & Hepatology
Fang Jiang, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wai K. Leung
Summary: The failure rates of clarithromycin-containing triple therapy for H. pylori have been increasing over the past 15 years in Hong Kong. Younger patients have higher failure rates, which could undermine the potential benefits of early H. pylori eradication.
Article
Gastroenterology & Hepatology
Yin Tong, Priscilla S. W. Cheng, Chung Sze Or, Sarah S. K. Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y. K. Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S. Y. Chan, April S. Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H. N. Yan
Summary: Cell-cell and cell-matrix adhesions play a critical role in gastric cancer progression, especially in gastric cancer with dysregulated RHO signaling.
Article
Oncology
Josephine Mun Yee Ko, Ka On Lam, Dora Lai Wan Kwong, Ian Yu-Hong Wong, Fion Siu-Yin Chan, Claudia Lai-Yin Wong, Kwan Kit Chan, Tsz Ting Law, Keith Wan Hang Chiu, Candy Chi Shan Lam, Jean Chrysei Wong, Henry Chun Hung Fong, Faith Sin Fai Choy, Andy Lo, Simon Law, Maria Li Lung
Summary: Esophageal cancer is a aggressive disease with low survival rates. Circulating tumor cells (CTCs) can be used as predictive and prognostic biomarkers for therapeutic responses and disease progression. Longitudinal CTC monitoring can provide useful information for prediction of treatment efficacies and disease progression, and it can be used as a non-invasive liquid biopsy for supplementary information with clinical imaging.
Article
Oncology
Wing-Lok Chan, Xiaodong Liu, Carlos King-Ho Wong, Michael Siu-Nam Wong, Ian Yu-Hong Wong, Ka-On Lam, Bryan Ho-Kwan Yun, Emina Edith Cheung, Rosa Pui-Ying Tse, Fion Chan, Simon Law, Dora Kwong
Summary: This study aimed to evaluate the efficacy of adjuvant chemotherapy in older patients (aged ≥65 years old) after D2-gastrectomy for gastric cancer. The results showed that adjuvant chemotherapy was associated with improved overall survival (OS) and cancer-specific survival (CSS) compared to surgery alone. There was no significant difference in survival benefit between monotherapy and doublets chemotherapy.
Article
Gastroenterology & Hepatology
Wai K. Leung, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Thomas K. L. Lui
Summary: Machine learning models, particularly XGBoost, can accurately predict the risk of gastric cancer after H. pylori eradication based on simple patient information, reducing the need for endoscopic surveillance. This model outperforms conventional logistic regression and provides valuable insight into identifying high-risk patients for post-eradication gastric cancer.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Yun Zhu, Alfred K. Y. Lam, Daisy K. Y. Shum, Di Cui, Jun Zhang, Dong Dong Yan, Bin Li, Wen Wen Xu, Nikki P. Y. Lee, Kin Tak Chan, Simon Law, Sai Wah Tsao, Annie L. M. Cheung
Summary: This study provides evidence that elevated serum SRGN has prognostic significance in patients with ESCC, and sheds light on the molecular mechanism by which elevated circulating SRGN in cancer patients might promote cancer progression. SRGN promotes invasion and metastasis in ESCC through activating ERK pathway and stabilizing c-Myc, and induces the secretion of midkine in an autocrine manner, forming a SRGN/MDK/CD44 complex. Interactions between SRGN, MDK, and matrix metalloproteinase 2 in ESCC are mediated by GAG chains rich in chondroitin sulfate.