Article
Gastroenterology & Hepatology
Kwangwoo Nam, Jae Yong Lee, Yousun Ko, Kyung Won Kim, Ho-Su Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byoun, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
Summary: This study investigated the prevalence of sarcopenia at diagnosis and its clinical significance in Korean patients with IBD. The results showed that 56.8% of the population had sarcopenia, with higher prevalence in male patients. Sarcopenia may be associated with an increased risk of perianal surgeries in patients with CD.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pathology
Federica Grillo, Luca Carlin, Andrea Remo, Matteo Fassan, Claudia Mescoli, Michela Campora, Luigi Caserta, Fabrizio Mazza, Luca Mastracci
Summary: Dasatinib-induced colitis may present histological features similar to Crohn's disease, including microgranulomas and active inflammation, and complete remission can be achieved after treatment interruption.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Nutrition & Dietetics
Alessandra Vincenti, Federica Loperfido, Rachele De Giuseppe, Matteo Manuelli, David Bosoni, Alessandra Righi, Rossella E. Nappi, Hellas Cena
Summary: Crohn's disease is a chronic inflammatory bowel disease that can impact female fertility. Diet plays a crucial role in supporting reproductive health in women, but efforts to improve awareness among women with Crohn's disease need to be made.
Review
Nutrition & Dietetics
Judith Wellens, Severine Vermeire, Joao Sabino
Summary: The article discusses the impact of diet on Crohn's disease, emphasizing the importance of dietary choices and the potential risk of malnutrition with restrictive diets. It also highlights the need for exploring new therapeutic approaches for long-term management of the disease and identifies areas for future research.
Article
Gastroenterology & Hepatology
Ferdinando D'Amico, Laurent Peyrin-Biroulet, Silvio Danese
Summary: Ustekinumab, a monoclonal antibody targeting IL-12 and IL-23, has shown efficacy and safety in treating moderate to severe Crohn's disease patients, but there is currently no approved therapeutic algorithm.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Takahiro Miyazu, Natsuki Ishida, Ryosuke Takano, Satoshi Tamura, Mihoko Yamade, Yasushi Hamaya, Shinya Tani, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Summary: The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) is a useful tool in evaluating mucosal lesions in patients with small intestinal CD in clinical remission and can help assess the need for additional treatment, including those who undergo intestinal resection.
Article
Biology
Tatiana D. Saccon, Joseph M. Dhahbi, Augusto Schneider, Yury O. Nunez Lopez, Ahmad Qasem, Marcelo B. Cavalcante, Lauren K. Sing, Saleh A. Naser, Michal M. Masternak
Summary: MicroRNAs are small RNA molecules that play important roles in various diseases, including Crohn's disease and rheumatoid arthritis. Our study identified a large number of differentially expressed miRNAs in the blood of patients with these autoimmune diseases, suggesting their potential as biomarkers. Furthermore, we found that these miRNAs regulate similar biological processes, indicating their possible involvement in disease mechanisms.
Article
Immunology
Nassim Hammoudi, Sarah Hamoudi, Julie Bonnereau, Hugo Bottois, Kevin Perez, Madeleine Bezault, Deborah Hassid, Victor Chardiny, Celine Grand, Brice Gergaud, Joelle Bonnet, Leila Chedouba, My-Linh Tran Minh, Jean-Marc Gornet, Clotilde Baudry, Helene Corte, Leon Maggiori, Antoine Toubert, Jacqueline McBride, Camille Brochier, Margaret Neighbors, Lionel Le Bourhis, Matthieu Allez
Summary: This study developed an ex vivo model to assess lympho-epithelial interactions in Crohn's Disease (CD) patients. The results showed that mucosal T cells from CD patients have a direct deleterious effect on the epithelial cells, while this effect is not observed in controls. This effect can be inhibited by limiting lympho-epithelial interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura A. Lucaciu, Radu Seicean, Alina Uifalean, Maria Iacobescu, Cristina A. Iuga, Andrada Seicean
Summary: This study identified a unique serum biomarker panel for predicting the progression of Crohn's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Eduard Brunet, Emili Vela, Luigi Melcarne, Laura-Patricia Llovet, Anna Puy, Montserrat Cleries, Caridad Pontes, Pilar Garcia-Iglesias, Albert Villoria, Gilaad G. Kaplan, Xavier Calvet
Summary: This study observed a remarkable geographical heterogeneity in the utilization of different treatments and outcomes for Crohn's disease patients in Catalonia. There was variability in the use of systemic corticosteroids, non-biological and biological immunosuppressant treatments, as well as hospitalization and surgical intervention rates across different geographical areas.
ANNALS OF MEDICINE
(2022)
Article
Immunology
Jiankang Xiang, Jiao Li, Chuan Liu, Shan Tian, Weiguo Dong
Summary: This study aimed to evaluate and compare the clinical features in various groups of CD patients stratified by age at diagnosis according to Montreal classification. The results showed that there were differences in clinical symptoms, laboratory test results, as well as disease locations and behaviors among CD patients stratified by age at diagnosis. These differences could guide early treatment or interventions for CD patients who might progress to a more complex disease behavior.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Leticia Rodrigues de Souza, Daniela Oliveira Magro, Fabio Vieira Teixeira, Rogerio Serafim Parra, Eron Fabio Miranda, Omar Feres, Rogerio Saad-Hossne, Giedre Soares Prates Herrerias, Renato Mitsunori Nisihara, Claudio Saddy Rodrigues Coy, Ligia Yukie Sassaki, Paulo Gustavo Kotze
Summary: Despite some variability in ADA concentrations, higher concentrations are associated with sustained efficacy and low levels can lead to loss of response in CD patients. This study aimed to correlate serum ADA concentrations with clinical and endoscopic activity in CD patients. The results showed no difference in serum ADA concentrations in active or remission CD patients, suggesting no correlation between ADA concentrations and disease activity.
Review
Nutrition & Dietetics
Bruno Augusto Alves Martins, Oswaldo de Moraes, Ana Carolina Benvindo Lopes, Ricardo Jacaranda de Faria, Clislian Silva, Gabriela de Oliveira Lemos, Dannilo Brito Silveira, Joao Batista de Sousa
Summary: Symptomatic perianal disease in patients with Crohn's disease is associated with a poor prognosis and challenging treatment. Nutritional deficiencies are common among these patients and can impact clinical outcomes and postoperative complications. Despite the high rate of surgeries, there is a lack of studies examining the influence of nutritional status on the course and outcomes of perianal disease, highlighting the need for further research.
FRONTIERS IN NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Yip Han Chin, Cheng Han Ng, Snow Yunni Lin, Sneha Rajiv Jain, Gwyneth Kong, Jeffery Wei Heng Koh, Darren Jun Hao Tan, David Eng Hui Ong, Mark Dhinesh Muthiah, Choon Seng Chong, Fung Joon Foo, Rupert Leong, Webber Pak Wo Chan
Summary: Upper gastrointestinal Crohn's disease (UGI-CD) is a significant subclassification of Crohn's Disease (CD) with a prevalence of 13%. It is most commonly found in the stomach and associated with concurrent ileocolonic involvement. Patients with L4-jejunal disease are more likely to require surgery.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Pharmacology & Pharmacy
Min Zhong, Bota Cui, Jie Xiang, Xia Wu, Quan Wen, Qianqian Li, Faming Zhang
Summary: This study found that rapamycin may be effective for CD-related strictures in the upper gastrointestinal tract, but not in lower gastrointestinal tract, with a certain rate of adverse events. No deaths or serious opportunistic infections were observed in the study.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Carrie L. Falling, Simon Stebbings, G. David Baxter, Corey A. Siegel, Richard B. Gearry, Ramakrishnan Mani
Summary: This study aimed to investigate pain processing pathways in patients with inflammatory bowel disease (IBD) using somatosensory testing and assess associations with multiple patient factors. The results showed that the absence of a stoma and female sex were associated with greater pressure sensitivity in remote body regions, suggesting widespread hyperalgesia. In addition, worse abdominal pain severity and biologic therapy use were associated with decreased pain inhibition, while biologic therapy use was also associated with increased pain facilitation. These findings suggest altered pain processing and central sensitization mechanisms in patients with IBD.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Stephanie C. Brown, Kevin Whelan, Chris Frampton, Catherine L. Wall, Richard B. Gearry, Andrew S. Day
Summary: Food-related quality of life is impaired in children with Crohn's disease compared with their healthy siblings and healthy control subjects. Age and nutritional risk (weight, height, and body mass index) are associated with poorer food-related quality of life in children with Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Gilaad G. Kaplan, Fox E. Underwood, Stephanie Coward, Manasi Agrawal, Ryan C. Ungaro, Erica J. Brenner, Richard B Gearry, Michele Kissous-Hunt, James D. Lewis, Siew C. Ng, Jean-Francois Rahier, Walter Reinisch, Flavio Steinwurz, Xian Zhang, Michael D. Kappelman, Jean-Frederic Colombel
Summary: The reporting of COVID-19 in inflammatory bowel disease (IBD) patients shows temporal trends that are consistent with the global epidemiological patterns of COVID-19.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Psychology, Clinical
Bree Hayes, Pragalathan Apputhurai, Antonina Mikocka-Walus, Manuel Barreiro-de Acosta, Charles N. Bernstein, Rebecca Burgell, Johan Burisch, Floor Bennebroek Evertsz, Nuno Ferreira, Lesley A. Graff, Ines A. Trindade, Richard Gearry, Bobby Lo, Anna Mokrowiecka, Gabriele Moser, Megan Petrik, Andreas Stengel, Simon R. Knowles
Summary: The study used an extended common sense model to evaluate the impact of fear of COVID-19 on quality of life in an international cohort with inflammatory bowel disease. The findings suggest that interventions targeting individual perceptions of fear of COVID-19 may enhance quality of life during the pandemic.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2022)
Article
Gastroenterology & Hepatology
Akhilesh Swaminathan, Dali Fan, Grace M. Borichevsky, Thomas C. Mules, Esther Hirschfeld, Chris M. Frampton, Andrew S. Day, Corey A. Siegel, Richard B. Gearry
Summary: The Disease Severity Index (DSI) is associated with psychological distress, impaired quality-of-life (QoL), and predicts a more complicated disease course in patients with inflammatory bowel disease (IBD).
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Hassan Azhari, James A. King, Stephanie Coward, Joseph W. Windsor, Christopher Ma, Shailja C. Shah, Siew C. Ng, Joyce W. Y. Mak, Paulo G. Kotze, Shomron Ben-Horin, Edward V. Loftus, Charlie W. Lees, Richard Gearry, Johan Burisch, Peter L. Lakatos, Xavier Calvet, Francisco Javier Bosques Padilla, Fox E. Underwood, Gilaad G. Kaplan
Summary: Peptic ulcer disease is a common cause of hospitalization worldwide, but hospitalization rates and mortality rates for PUD have consistently been decreasing in the 36 OECD countries since the turn of the 21st century.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Simone B. Bayer, Chris M. Frampton, Richard B. Gearry, Giovanni Barbara
Summary: Research has found that kiwifruit intake can alleviate upper gastrointestinal symptoms, especially abdominal discomfort and pain. Green kiwifruit appears to have a better effect in relieving gastrointestinal symptoms, but more studies are needed to strengthen the evidence.
ADVANCES IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
Summary: This study investigated the association between disease activity and sexual dysfunction in patients with inflammatory bowel disease. The results showed that objective measures of disease activity were not associated with sexual dysfunction, but psychological symptoms played a role.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Sally Mortlock, Anton Lord, Grant Montgomery, Martha Zakrzewski, Lisa A. Simms, Krupa Krishnaprasad, Katherine Hanigan, James D. Doecke, Alissa Walsh, Ian C. Lawrance, Peter A. Bampton, Jane M. Andrews, Gillian Mahy, Susan J. Connor, Miles P. Sparrow, Sally Bell, Timothy H. Florin, Jakob Begun, Richard B. Gearry, Graham L. Radford-Smith
Summary: This study identified genetic loci associated with medically refractory ulcerative colitis (UC) through a genome wide association analysis. The findings suggest different genetic risk factors for medically refractory UC compared to non-medically refractory UC. Further research may uncover additional loci related to disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Alice MacIntosh, Phoebe E. Heenan, Morag Wright-McNaughton, Chris Frampton, Paula Skidmore, Catherine L. Wall, Jane Muir, Nicholas Joseph Talley, Nicole Clemence Roy, Richard B. Gearry
Summary: This study investigated the relationship between habitual FODMAP intake and post-prandial bowel symptoms in adults with IBS, FD, or FC, as well as in healthy adults. The results showed that IBS participants experienced more post-prandial bowel symptoms compared to participants with other functional bowel disorders or controls. Different symptoms were associated with different types of FODMAP intake.
FRONTIERS IN NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Alexander T. Elford, Rupert W. Leong, Emma P. Halmos, Manal Morgan, Kate Kilpatrick, Peter J. Lewindon, Richard B. Gearry, Britt Christensen
Summary: Australasia, including Australia, New Zealand, and Papua New Guinea, has a high prevalence of inflammatory bowel disease (IBD), and the practice of IBD medicine varies within this region. This review discusses barriers to IBD care across Australasia from the perspective of local healthcare professionals, including access to multidisciplinary teams, nutritional therapies, mental health disorders associated with IBD, medication availability, endoscopy access, rural barriers to care, Indigenous IBD care, and pediatric issues. The aim is to identify areas for improvement in IBD care and address research needs in Australasia.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Pediatrics
Stephanie Christine Brown, Catherine L. Wall, Richard B. Gearry, Andrew S. Day
Summary: Crohn's disease (CD) is a chronic, incurable and relapsing disease that affects the gastrointestinal tract. Exclusive enteral nutrition (EEN) is the first-line therapy for CD, but little is known about the patient experience of EEN. This study aimed to assess children's experiences of EEN and understand their mindset. The findings show that limited formula flavors and the need for support are important challenges for children on EEN. Psychological support strategies should be developed to ensure successful implementation of EEN in children.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Correction
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Bobby Lo, Manuel Barreiro-de Acosta, Charles N. Bernstein, Johan Burisch, Nuno Ferreira, Richard B. Gearry, Antonina Mikocka-Walus, Anna Mokrowiecka, Ines A. Trindade, Simon R. Knowles
Summary: This study aimed to compare the fear of coronavirus-19 in patients with inflammatory bowel disease to other gastrointestinal conditions and explore how fear manifests in different demographic backgrounds. The results showed that patients with inflammatory bowel disease had a higher fear of coronavirus-19, especially those on sick leave or living in rural areas.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Adriaan G. Volkers, Laura Appleton, Richard B. Gearry, Christopher M. Frampton, Floris A. E. de Voogd, Annemieke M. Peters van Ton, Steven T. Leach, Daniel A. Lemberg, Andrew S. Day
Summary: This study evaluated the performance of fecal biomarkers FC, CHI3L1, S100A12, and OPG in children with Crohn's disease and compared them with other measures of disease activity. The results showed that FC correlated with both endoscopic and clinical disease activity and was the only biomarker that differentiated between active and inactive ileal CD. CHI3L1 also predicted clinical disease activity and correlated highly with FC.
GASTROINTESTINAL DISORDERS
(2022)