Article
Gastroenterology & Hepatology
Hyo Seon Ryu, Chang Sik Yu, Young Il Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Summary: Pouch adenomas occur at a fairly high rate in FAP patients after restorative proctocolectomy, and a high colorectal polyp count is associated with pouch adenoma development.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Danujan Sriranganathan, Yakup Kilic, Mohammed Nabil Quraishi, Jonathan P. Segal
Summary: The study found that the prevalence of pouchitis is higher in UC patients compared to FAP patients. The true prevalence of pouchitis may be higher than commonly reported, which could be useful in counseling patients before undergoing restorative proctocolectomy.
COLORECTAL DISEASE
(2022)
Review
Gastroenterology & Hepatology
Danujan Sriranganathan, Danilo Vinci, Gianluca Pellino, Jonathan P. Segal
Summary: This study conducted a systematic review with meta-analysis to investigate the incidence of pouch cancer in patients with ulcerative colitis (UC) and familial adenomatous polyposis (FAP). The findings indicate that the pooled incidence of pouch cancer in UC is similar to previous studies, and it is the first meta-analysis to report the pooled incidence for pouch cancer in FAP.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Rodrigo Castano Llano, Sandra Patricia Molina Meneses, Juan Dario Puerta, Rene Marcelo Escobar, Santiago Salazar Ochoa, Juan Esteban Puerta, Manuel Barreiro-de Acosta
Summary: This study evaluated long-term postoperative complications and satisfaction with the procedure in patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC). The study found a higher rate of reservoiritis in UC patients compared to FAP, but UC patients had higher overall satisfaction and quality of life after surgery. In contrast, FAP patients had lower overall satisfaction.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Surgery
Hiroaki Nozawa, Keisuke Hata, Kazuhito Sasaki, Koji Murono, Kazushige Kawai, Shigenobu Emoto, Soichiro Ishihara
Summary: This study compared the outcomes of laparoscopic surgery and open surgery in patients with UC or FAP, and found that laparoscopic surgery resulted in reduced blood loss and promoted bowel recovery, with similar operative time and complication rates compared to open surgery.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Pediatrics
Rebecca A. Saberi, Gareth P. Gilna, Cindy Rodriguez, Walter A. Ramsey, Carlos T. Huerta, Christopher F. O'Neil, Joshua P. Parreco, Amber H. Langshaw, Chad M. Thorson, Juan E. Sola, Eduardo A. Perez
Summary: This study compared the morbidity of open versus laparoscopic colectomy or proctocolectomy for pediatric patients with ulcerative colitis using national readmission outcomes. The results showed that laparoscopic surgery was associated with shorter hospital stay, fewer post-operative complications, and improved readmission outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Review
Gastroenterology & Hepatology
M. Machin, H. -C. Younan, A. A. P. Slesser, Y. Mohsen
Summary: Ileoanal pouch-vaginal fistula is a common complication of restorative proctocolectomy, with both local and abdominal approaches showing high failure rates in its management. The review results can guide patient counseling and call for higher quality research in this area.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Y. Zhang, H. Hu, C. Jiang, Q. Qian, Z. Ding
Summary: This study evaluated the feasibility and safety of D-IPAA compared to J-IPAA in patients with FAP and UC, finding that D-IPAA had a shorter construction time and good functional outcomes postoperatively, with the potential to reduce the risk of pouch leaks.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Review
Oncology
Guillaume Le Cosquer, Etienne Buscail, Cyrielle Gilletta, Celine Deraison, Jean-Pierre Duffas, Barbara Bournet, Geraud Tuyeras, Nathalie Vergnolle, Louis Buscail
Summary: Proctocolectomy with ileal pouch-anal anastomosis is the recommended surgical intervention for ulcerative colitis and familial adenomatous polyposis. However, there is a risk of high-grade dysplasia and cancer in the anal transitional zone and ileal pouch after 20 years, with estimated rates of 2% to 4.5% and 3% to 10% in ulcerative colitis and familial polyposis, respectively. Risk factors for ulcerative colitis include pre-operative dysplasia or cancer, disease duration > 10 years, and severe villous atrophy. For familial polyposis, risk factors include > 1000 pre-operative polyps, stapled anastomosis, and duration of follow-up. While anal transitional zone and ileal pouch cancers rarely occur after proctectomy, the high mortality rate associated with this complication necessitates close endoscopic monitoring.
Article
Gastroenterology & Hepatology
Allie E. Steinberger, Maggie L. Westfal, Paul E. Wise
Summary: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder caused by germline mutations in the adenomatous polyposis coli (APC) gene. Surgical treatment options for FAP include total colectomy with ileorectal anastomosis, proctocolectomy with ileal pouch-anal anastomosis, or total proctocolectomy with end ileostomy. This article discusses the different surgical approaches, as well as the use of endoscopy and chemoprevention for managing polyposis in FAP patients. It also addresses important management decisions, such as the timing of prophylactic colorectal resections and the management of rectal polyp burden, and explores the impact of genotype and desmoid disease on operative decisions in FAP.
CLINICS IN COLON AND RECTAL SURGERY
(2023)
Article
Medicine, Research & Experimental
Behrooz Keleidari, Mohsen Mahmoudieh, Mohammad Shiasi
Summary: This study evaluated the complications of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis in patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC). The results showed that this surgical method had the least complications and the highest level of satisfaction for young patients with FAP and UC, making it a suitable choice for these patients.
ADVANCED BIOMEDICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Mohammed Deputy, Jonathan Segal, Lillian Reza, Guy Worley, Samuel Costello, Elaine Burns, Omar Faiz, Susan Clark, Ailsa Hart
Summary: The management of the pouch behaving badly requires a careful clinical assessment to identify potential underlying pathologies. The patient may present with a variety of symptoms, necessitating a thorough examination and specialist investigation. Understanding the specific causes of this clinical scenario is essential for effective treatment and improvement of quality of life.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
N. Jewel Samadder, Ryan P. McMurray, Priyanka Kanth, Michael Sossenheimer, Michelle Westover, Luz M. Rodriguez, David Zahrieh, Nathan Foster, Carol A. Burke, Elena Stoffel, Rohit Das, Marcia Cruz-Correa, E. Vilar, Gautam Mankaney, Navtej Buttar, Selvi Thirumurthi, Danielle K. Turgeon, Ellen Richmond, Asad Umar, Gary Della'Zanna, Eva Szabo, Paul J. Limburg
Summary: In this study, the efficacy and adverse effects of once weekly erlotinib intervention were evaluated in patients with FAP. The results showed that once weekly erlotinib intervention significantly reduced duodenal polyp burden and moderately reduced lower gastrointestinal polyp burden. Although adverse effects still occurred, most events were low-grade and well-tolerated.
Article
Gastroenterology & Hepatology
John Gasdal Karstensen, Steffen Bulow, Helle Hojen, Anne Marie Jelsig, Niels Jespersen, Klaus Kaae Andersen, Mads Damsgaard Wewer, Johan Burisch, Hans Christian Pommergaard
Summary: This study found that patients with familial adenomatous polyposis (FAP) have a significantly higher risk of developing cancer compared to controls, mainly due to increased risks of colorectal, pancreatic, and duodenal/small-bowel cancers. Additionally, the risk of developing a second primary cancer is also significantly higher for FAP patients.
Article
Genetics & Heredity
Martin R. Graf, Shruti Apte, Esteban Terzo, Simran Padhye, Shuhao Shi, Megan K. Cox, Roger B. Clark, Vijay Modur, Vasudeo Badarinarayana
Summary: Familial adenomatous polyposis (FAP) is a colorectal disease caused by mutations in the APC gene, leading to the growth of adenomatous polyps. The novel macrolide, ZKN-0013, has been shown to restore the function of the APC protein and inhibit the beta-catenin/wnt-pathway in human colon carcinoma cells and a mouse model of FAP. Treatment with ZKN-0013 reduced the number of intestinal polyps, adenomas, anemia, and improved survival.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)