Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
D. F. Altomare, A. Picciariello, A. Di Ciaula, M. Rinaldi, M. De Fazio, P. Portincasa
Summary: Temporary sacral nerve stimulation (SNS) did not have any effect on upper/lower gastrointestinal motility and transit in patients with severe constipation.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Nicholas J. Talley, Gerald J. Holtmann, Bridget R. Southwell, David Fisher, Natasha A. Koloski, Michael Jones
Summary: This article is related to the papers by Sharma et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Urology & Nephrology
Glicia Estevam de Abreu, Leonardo Azevedo de Souza, Maria Luiza Veiga da Fonseca, Tamara Barreto Carneiro Barbosa, Eneida Regis Dourado de Mello, Ananda Nacif Baiao Nunes, Ubirajara de Oliveira Barroso Jr
Summary: This study aimed to evaluate the effectiveness of parasacral transcutaneous electrical nerve stimulation in treating bladder and bowel dysfunction in children and adolescents. The results showed significant improvement in functional constipation post-intervention in the treatment group compared to the control group.
JOURNAL OF UROLOGY
(2021)
Article
Pediatrics
Carlos Velasco-Benitez, Eder Villamarin, Melissa Mendez, Alfredo Linero, Gregory Hungria, Miguel Saps
Summary: Functional constipation in children can be improved with conventional treatments, but some children may have poor treatment outcomes. This study found that transcutaneous PTNS shows significant improvement in stool consistency, fecal incontinence, abdominal pain, and hematochezia, suggesting it could be a promising noninvasive treatment for children with functional constipation. However, more extensive studies are needed for further validation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Steven Zhou, Nasir Hussain, Alaa Abd-Elsayed, Racha Boulos, Mohammed Hakim, Mayank Gupta, Tristan Weaver
Summary: Headaches are a common medical complaint worldwide, with peripheral nerve stimulation emerging as a novel treatment for intractable headaches. While evidence supports its use, efficacy is limited to specific nerves and headache types, requiring further research for mainstream adoption.
Article
Anesthesiology
Kai-kai Guo, Long Wang, Fang Liu, Jie-jie Niu, Chao Wang, Shao-hua You, Ze-guo Feng, Gui-jun Lu
Summary: SNS can effectively alleviate pain severity, improve quality of life, and prolong sleep duration in patients with refractory PN.
Article
Neurosciences
Xue Jin, Payam Gharibani, Jieyun Yin, Jiande D. Z. Chen
Summary: Sacral nerve stimulation can improve visceral hypersensitivity in rats by reducing mast cell overactivation, thus alleviating pain symptoms in the rodents.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Gastroenterology & Hepatology
Jacopo Martellucci, Alfredo Annicchiarico, Maximilian Scheiterle, Mario Trompetto, Paolo Prosperi
Summary: The present study evaluated the role of sacral neuromodulation for the treatment of constipation and other evacuation disorders after surgery. The results showed that sacral neuromodulation is a feasible, safe, and effective method with long-term benefits in the treatment of defecatory dysfunction after pelvic or colorectal surgery.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Computer Science, Interdisciplinary Applications
Rafael Moreta-Martinez, Ines Rubio-Perez, Monica Garcia-Sevilla, Laura Garcia-Elcano, Javier Pascau
Summary: This study proposes and evaluates two navigation systems for guiding electrode placement in sacral nerve stimulation (SNS) surgeries. Both navigation methods demonstrate better results than the standard clinical method in terms of reducing surgical time, minimizing patient discomfort, and improving surgical outcomes.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Medicine, General & Internal
Ximeng Wang, Jiande D. Z. Chen
Summary: The systematic review aims to introduce the clinical applications and potential mechanisms of sacral nerve stimulation (SNS) for various gastrointestinal diseases. The results showed that SNS is highly effective in treating fecal incontinence, but it is ineffective for constipation. Further research is needed to explore the potential applications of SNS for irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Review
Medicine, General & Internal
Stefan Evers
Summary: Neurostimulation methods have been studied for over 20 years in the treatment of migraines, with both invasive and non-invasive methods being utilized. Among the non-invasive methods, vagal nerve stimulation, electric peripheral nerve stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation are the most commonly studied and used. However, the efficacy of most procedures is poor due to a lack of consistent positive results from blinded, controlled trials with an adequate number of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Seyedhossein Aharinejad, Dietmar Abraham, Patrick Paulus, Karin Zins, Michael Hofmann, Wolfgang Michlits, Mariann Gyongyosi, Karin Macfelda, Trevor Lucas, Karola Trescher, Michael Grimm, E. Richard Stanley
CARDIOVASCULAR RESEARCH
(2008)
Article
Gastroenterology & Hepatology
Rudolf Schiessel, Michael Hofmann, Gabriele Novi, Brigitte Holzer
DISEASES OF THE COLON & RECTUM
(2007)
Article
Oncology
S Aharinejad, P Paulus, M Sioud, M Hofmann, K Zins, R Schäfer, ER Stanley, D Abraham
Article
Urology & Nephrology
D Abraham, S Abri, M Hofmann, W Höltl, S Aharinejad
JOURNAL OF UROLOGY
(2003)
Article
Oncology
S Aharinejad, D Abraham, P Paulus, H Abri, M Hofmann, K Grossschmidt, R Schäfer, ER Stanley, R Hofbauer
Article
Immunology
D Abraham, S Taghavi, P Riml, P Paulus, M Hofmann, C Baumann, A Kocher, W Klepetko, S Aharinejad
Article
Oncology
M Fakhari, D Pullirsch, D Abraham, K Paya, R Hofbauer, P Holzfeind, M Hofmann, S Aharinejad