Review
Infectious Diseases
Men-Bao Qian, Chandni Patel, Marta S. Palmeirim, Xiaoming Wang, Christian Schindler, Jurg Utzinger, Xiao-Nong Zhou, Jennifer Keiser
Summary: The study compares the efficacy of currently registered drugs against human liver fluke infection and finds that Praziquantel shows high efficacy against clonorchiasis and opisthorchiasis. Tribendimidine may serve as a treatment alternative and warrants further investigation. Although albendazole is efficacious when long treatment schedules are applied, the limited size of studies and high risk of bias affect the interpretation of results. More high-quality studies are needed to establish treatment guidelines for human liver fluke infection.
Article
Multidisciplinary Sciences
Munirah Alsaleh, Zoe Leftley, Thomas O'Connor, Thomas Hughes, Thomas A. Barbera, Larry K. Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen D. Ryder, Shaun Greer, Martin Prince, Paiboon Sithithaworn, Narong Khuntikeo, Watcharin Loilome, Puangrat Yongvanit, I. Jane Cox, Roger Williams, Christopher A. Wadsworth, Elaine Holmes, Kathryn Nash, Ross Andrews, Simon D. Taylor-Robinson
Summary: This study identified phenotypic diversity in urinary metabolomes of different geographical populations. Disparities in healthy metabolomes between two distinct populations were primarily related to differences in dietary practices and body composition, while metabolites excreted due to drug treatment were dominant in urine specimens from cholangiocarcinoma patients, particularly in Western individuals. Dysregulation in nucleotide metabolism associated with sporadic cholangiocarcinoma may indicate differences in mitochondrial energy production pathways between cholangiocarcinoma tumour subtypes, influenced by gut microbial community metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Wuttipong Phumrattanaprapin, Mark Pearson, Darren Pickering, Bemnet Tedla, Michael Smout, Sujittra Chaiyadet, Paul J. Brindley, Alex Loukas, Thewarach Laha
Summary: The study showed that monoclonal antibodies against Ov-TSP-2 can protect against opisthorchiasis in hamsters, indicating the potential of antibody-directed therapies for liver fluke infections. This supports the use of TSPs as components of a subunit vaccine for opisthorchiasis and similar infections.
Article
Microbiology
Alexandra Probst, Daniela Hofmann, Olga S. Fedorova, Sofia Mazeina, Tatiana S. Sokolova, Ekaterina Golovach, Jennifer Keiser
Summary: This study compares the pharmacokinetic properties of single, ascending doses of praziquantel to multiple dosing in patients infected with Opisthorchis felineus. The results contribute to updated treatment guidelines and provide a possible optimized treatment scheme for O. felineus-infected patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Sujittra Chaiyadet, Javier Sotillo, Watchara Krueajampa, Sophita Thongsen, Michael Smout, Paul J. Brindley, Thewarach Laha, Alex Loukas
Summary: This study investigated the uptake of parasite extracellular vesicles (EVs) by mammalian host tissues, focusing on the oriental liver fluke Opisthorchis viverrini. OvEVs were found to contain microRNAs that impact mammalian cell proliferation pathways. Tetraspanins on the surface of OvEVs were identified as potential biomarkers for these parasite vesicles and were also implicated in EV biogenesis/stability. Silencing of tetraspanin genes in adult flukes resulted in reduced OvEV secretion, highlighting the potential efficacy of anti-tetraspanin vaccines against parasitic helminth infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Urology & Nephrology
Pantipa Tonsawan, Sompote Intarak, Banchob Sripa, Anucha Puapairoj, Manop Sripa, Paiboon Sithithaworn, Sirirat Anutrakulchai
Summary: This study is the first to demonstrate the presence of Opisthorchis viverrini (OV) antigen in human kidney tissue, suggesting a possible association between OV infection and biopsy-proven glomerular diseases.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Parasitology
Jutharat Kulsantiwong, Veerachai Thitapakorn, Thanakrit Sathavornmanee, Siraphatsorn Yusuk, Opal Pitaksakulrat, Smarn Tesana, Sattrachai Prasopdee
Summary: This study determined the susceptibility of Bithynia siamensis siamensis and Bithynia funiculata to Opisthorchis viverrini, assessing the risk of non-endemic opisthorchiasis transmission. The results showed that B. siamensis siamensis had a higher susceptibility to O. viverrini infection compared to B. funiculata, indicating a greater risk of transmission.
PARASITOLOGY RESEARCH
(2022)
Article
Immunology
Wuttipong Phumrattanaprapin, Sujittra Chaiyadet, Paul J. Brindley, Mark Pearson, Michael J. Smout, Alex Loukas, Thewarach Laha
Summary: The study successfully developed an oral vaccine to prevent Opisthorchis viverrini infection in hamsters, resulting in a reduction in infection intensity. This vaccine may serve as the basis for controlling carcinogenic liver fluke infection in humans.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Parasitology
Makoto Sakamoto, Songkiad Upontain, Pornphutthachat Sota, Jeffrey Mariner, Prasarn Tangkawattana, Sirikachorn Tangkawattana
Summary: In areas with liver fluke infection, owned domestic cats play an important role in the transmission of the parasite. Cats become infected by eating raw fish and spread the parasite eggs through defecation. A study found that domestic cats prefer urban habitats and are mainly infected through contaminated fish fed to them. The lack of awareness among villagers hinders effective disease control.
Article
Microbiology
Janneke M. Brussee, Noemi Hiroshige, Anna Neodo, Jean T. Coulibaly, Marc Pfister, Jennifer Keiser
Summary: Research indicates that tribendimidine shows potential in treating hookworm infections, with combination therapy leading to higher cure rates. Exposure-response analysis suggests that combination therapy with ivermectin can achieve the desired >90% cure rates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Hung Manh Nguyen, Hien Hoang Van, Loan Thi Ho, Yulia V. Tatonova, Henry Madsen
Summary: The study aimed to clarify the suitability of two thiarid snail species, M. tuberculata and T. granifera, as first intermediate hosts of C. sinensis. Field surveys in Vietnam revealed that only Parafossarulus manchouricus was infected with C. sinensis, contradicting previous beliefs about the role of the other two snail species. Experimentally, only P. manchouricus was successfully infected with C. sinensis eggs.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Men-Bao Qian, Hong-Mei Li, Zhi-Hua Jiang, Yi-Chao Yang, Ming-Fei Lu, Kang Wei, Si-Liang Wei, Yu Chen, Chang-Hai Zhou, Ying-Dan Chen, Xiao-Nong Zhou
Summary: The study in Hengxian county, China found a significant association between Clonorchis sinensis infection and hepatobiliary morbidity, with certain conditions strongly related to the infection intensity. Therefore, raising awareness on the harm of clonorchiasis is crucial for policymakers and villagers to implement effective interventions.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Cell Biology
Piyanard Boonnate, Kulthida Vaeteewoottacharn, Ryusho Kariya, Sawako Fujikawa, Thidarut Boonmars, Somchai Pinlaor, Chawalit Pairojkul, Seiji Okada
Summary: A new hamster cholangiocarcinoma cell line, Ham-2, was established and characterized for its aggressive phenotypes in vitro and in vivo. This cell line could serve as a valuable tool for comparative drug target identification and validation in CCA research.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2021)
Article
Parasitology
Banchob Sripa, Melissa R. Haswell
Summary: This study investigated the activation of mast cells in cholecystitis associated with Opisthorchis viverrini infection. Results showed significantly higher numbers of mast cells in the lamina propria of gall bladder specimens from O. viverrini-infected patients. This suggests that mast cell hyperplasia may play a role in the pathogenesis of cholecystitis associated with opisthorchiasis.
PARASITOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Anna V. Kovner, Alena A. Tarasenko, Oxana Zaparina, Olga V. Tikhonova, Maria Y. Pakharukova, Viatcheslav A. Mordvinov
Summary: In this study, the wound healing potential of Opisthorchis felineus proteins in a mouse model was investigated. The results showed that these proteins could significantly enhance wound healing by reducing inflammation, modulating vascular response, and promoting dermal extracellular matrix remodeling.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Irene Scholz, Evangelia Liakoni, Felix Hammann, Katharina Elisabeth Grafinger, Urs Duthaler, Michael Nagler, Stephan Kraehenbuhl, Manuel Haschke
Summary: The study found that Hypericum perforatum extract induced CYP3A4 and P-gp activity, resulting in a decrease in rivaroxaban exposure and proportional decrease in pharmacodynamic effect. However, there were no clinically significant differences in peak concentration, time to peak concentration, and plasma elimination half-life of rivaroxaban.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Friederike Holze, Matthias E. Liechti, Nadia R. P. W. Hutten, Natasha L. Mason, Patrick C. Dolder, Eef L. Theunissen, Urs Duthaler, Amanda Feilding, Johannes G. Ramaekers, Kim P. C. Kuypers
Summary: This study investigated the pharmacokinetics and subjective effects of different doses of LSD on healthy participants. The results showed that 10 μg of LSD significantly enhanced subjective effects, serving as a threshold dose for psychotropic effects.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Friederike Holze, Patrick Vizeli, Laura Ley, Felix Mueller, Patrick Dolder, Melanie Stocker, Urs Duthaler, Nimmy Varghese, Anne Eckert, Stefan Borgwardt, Matthias E. Liechti
Summary: This study evaluated the subjective and autonomic effects of different doses of LSD in healthy subjects. It found that LSD displayed dose-proportional pharmacokinetics and dose-dependently induced subjective responses, with a ceiling effect observed for good drug effects at 100 μg. The results suggest that future LSD research may benefit from dose finding based on these findings, and that the full psychedelic effects of LSD are primarily mediated by serotonin 5-HT2A receptor activation.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fabio Bachmann, Urs Duthaler, Henriette E. Meyer zu Schwabedissen, Maxim Puchkov, Jorg Huwyler, Manuel Haschke, Stephan Kraehenbuehl
Summary: Metamizole is a widely used analgesic and antipyretic drug that induces multiple CYP enzymes through an interaction with CAR, while also inhibiting CYP1A2 activity. These findings have significant clinical implications due to the widespread use of metamizole.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemical Research Methods
Karolina E. Kolaczynska, Matthias E. Liechti, Urs Duthaler
Summary: A rapid LC-MS/MS method was developed and validated for quantifying psilocin and its metabolite 4-HIAA in human plasma, showing good accuracy and precision over three validation runs. This method could assess the pharmacokinetics of psilocin and 4-HIAA and facilitate the clinical development of psilocybin.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Pediatrics
Leonie Wagner-Hattler, Klara Kiene, Julia Bielicki, Marc Pfister, Maxim Puchkov, Joerg Huwyler
Summary: The study evaluated the acceptability of a novel child-appropriate oral dispersible tablet formulation. The results showed high acceptability among parents and children, with smooth administration process and no distress observed in any of the children. The proposed child-friendly dosage form is expected to improve drug adherence in pediatric patients.
Article
Pharmacology & Pharmacy
Fabio Bachmann, Urs Duthaler, Stephan Krahenbuhl
Summary: This study investigated the effect of deglucuronidation on the plasma concentration of the constituents of the Basel phenotyping cocktail. The results showed that deglucuronidation of plasma samples improves the stability of phenotyping results and is necessary to reliably detect CYP induction.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Benjamin Berger, Jasper Dingemanse, Giancarlo Sabattini, Stephane Delahaye, Urs Duthaler, Clemens Muehlan, Stephan Kraehenbuehl
Summary: The study evaluated the impact of hepatic impairment on the metabolism and tolerability of daridorexant, finding that moderate liver cirrhosis causes impaired hepatic clearance of unbound daridorexant, prolonging the half-life.
CLINICAL PHARMACOKINETICS
(2021)
Article
Biochemistry & Molecular Biology
Laura Nicolle, Jens Casper, Melanie Willimann, Celine M. A. Journot, Pascal Detampel, Tomaz Einfalt, Hiu Man Grisch-Chan, Beat Thony, Sandrine Gerber-Lemaire, Jorg Huwyler
Summary: The study developed a novel chitosan-derivative, dCS-Suc-LPEI-14, showing promising biocompatibility, cytotoxicity, and transfection efficiency. Through in vitro and in vivo experiments, its potential for non-viral gene therapy was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Parasitology
Patricia Nicolas, Caroline Kiuru, Martin G. Wagah, Martha Muturi, Urs Duthaler, Felix Hammann, Marta Maia, Carlos Chaccour
Summary: The study found that dual inhibition of xenobiotic pumps and cytochromes has a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin.
PARASITES & VECTORS
(2021)
Article
Pharmacology & Pharmacy
Fabio Bachmann, Henriette E. Meyer Zu Schwabedissen, Urs Duthaler, Stephan Kraehenbuehl
Summary: CYP1A2 is the major CYP involved in the metabolism of 4-MAA, with CYP2C19 and CYP2D6 also contributing. Inhibition of CYP1A2 and the combination of CYP1A2/CYP2C19 may increase the exposure of 4-MAA, leading to dose-dependent adverse reactions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anna M. Becker, Friederike Holze, Tanja Grandinetti, Aaron Klaiber, Vanja E. Toedtli, Karolina E. Kolaczynska, Urs Duthaler, Nimmy Varghese, Anne Eckert, Edna Grunblatt, Matthias E. Liechti
Summary: The study examined the interaction between escitalopram and psilocybin in the treatment of depression and anxiety. Escitalopram pretreatment was found to reduce certain negative effects of psilocybin, but further research is needed to fully understand the interactions between antidepressants and psilocybin in patients with psychiatric disorders.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Virology
Patrick Hauswirth, Philipp Graber, Katarzyna Buczak, Riccardo Vincenzo Mancuso, Susanne Heidi Schenk, Juerg P. F. Nueesch, Jorg Huwyler
Summary: Mutated NS1 variants, particularly the NS1-T585E single-amino acid mutant, showed potential oncotoxic effects in human hepatocellular carcinoma cell lines. Proteomics analysis revealed new interaction partners and signaling pathways of NS1, providing mechanistic explanations for its oncolytic effects.
Review
Pharmacology & Pharmacy
Klervi Golhen, Michael Buettcher, Jonas Kost, Joerg Huwyler, Marc Pfister
Summary: The majority of therapeutics currently available are not suitable for pediatric patients, thus there is a need to develop child-friendly dosage forms. This review discusses the challenges and opportunities in the development of such dosage forms, including taste masking, tablet size, dose flexibility, excipient safety, and acceptability. It also explores the example of orally dispersible tablets (ODTs) as a child-friendly drug delivery strategy, utilizing inorganic particulate drug carriers as multifunctional excipients to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations.
Meeting Abstract
Pharmacology & Pharmacy
Benjamin Berger, Jasper Dingemanse, Giancarlo Sabattini, Urs Duthaler, Clemens Muehlan, Stephan Krahenbuhl
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)