Article
Medicine, General & Internal
Natalia Saldana-Garcia, Maria Gracia Espinosa-Fernandez, Celia Gomez-Robles, Antonio Javier Postigo-Jimenez, Nicholas Bello, Francisca Rius-Diaz, Tomas Sanchez-Tamayo
Summary: A single dose of betamethasone up to 3 h before delivery may reduce the rate of serious outcomes and the severity of neonatal RDS, especially in non-tertiary hospitals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Natalia Saldana-Garcia, Maria Gracia Espinosa-Fernandez, Jose David Martinez-Pajares, Elias Tapia-Moreno, Maria Moreno-Samos, Celia Cuenca-Marin, Francisca Rius-Diaz, Tomas Sanchez-Tamayo
Summary: This retrospective cohort study compared the effects of administering two doses of betamethasone 12 hours apart to the traditional regimen in preterm infants. The results showed that the shorter interval between doses did not increase the incidence of morbidity and had similar outcomes in terms of mortality and severe morbidities. There were no adverse effects on neurodevelopment at 24 months of corrected age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Homeira Vafaei, Fahimeh Kaveh Baghbahadorani, Nasrin Asadi, Maryam Kasraeian, Azam Faraji, Shohreh Roozmeh, Marjan Zare, Khadije Bazrafshan
Summary: Maternal administration of betamethasone resulted in significant changes in fetal blood velocity waveforms and affected blood flow in the pulmonary artery, leading to increased pulmonary artery AT and AT/ET. Among fetuses with RDS, there was a significant decrease in pulmonary artery AT, but no differences were observed in pulmonary artery AT/ET.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Mary T. Kinney, Sara K. Quinney, Hayley K. Trussell, Larissa L. Silva, Sherrine A. Ibrahim, David M. Haas
Summary: Among women receiving antenatal betamethasone therapy, cesarean delivery was the only maternal factor associated with neonatal respiratory distress syndrome (RDS). However, preterm premature rupture of membranes (PPROM) was negatively associated with RDS rates among women delivering within 14 days of betamethasone dosing. Other maternal characteristics such as age, BMI, race, and ethnicity were not significantly associated with RDS.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Biochemistry & Molecular Biology
Artem Bonchuk, Konstantin Balagurov, Pavel Georgiev
Summary: The article provides a translation of the importance of BTB/POZ domains in eukaryotic organisms, as well as their role in various developmental processes and oncological diseases. Structural studies have revealed the principles of protein-protein interactions mediated by BTB domains and provided a basis for specific inhibition of these interactions. BTB domains originated early in evolution and progressively adapted to perform different functions. The article also proposes an updated structure-based classification of BTB domain families and discusses their evolutionary interconnections.
Article
Medicine, Research & Experimental
Camilla Margaroli, Timothy Fram, Nirmal S. Sharma, Siddharth B. Patel, Jennifer Tipper, Sarah W. Robison, Derek W. Russell, Seth D. Fortmann, Mudassir M. Banday, Yixel Soto-Vazquez, Tarek Abdalla, Sawanan Saitornuang, Matthew C. Madison, Sixto M. Leal Jr, Kevin S. Harrod, Nathaniel B. Erdmann, Amit Gaggar
Summary: Neutrophilic inflammation is observed in respiratory viral infections, including COVID-19-related acute respiratory distress syndrome, but its role in disease pathogenesis is unclear. This study phenotyped immune cells in the blood and airway of 52 severe COVID-19 patients and identified two subpopulations of neutrophils. The loss of one neutrophil subset correlated with increased viral burden and decreased survival. Further experiments showed that this subset exhibited an antiviral response, which was dependent on type I interferon signaling. Understanding this neutrophil phenotype could lead to new therapeutic approaches for viral illnesses.
Article
Pharmacology & Pharmacy
Qun Zhou, Jianjun Jiang, Guanjun Chen, Cheng Qian, Gengyun Sun
Summary: This study investigated the molecular mechanism of endothelial barrier dysfunction induced by inflammatory immune cytokines in acute respiratory distress syndrome (ARDS). The results showed that TNF-alpha induced phosphorylated Ezrin protein via the FAK/RhoA signaling pathway, leading to endothelial hyperpermeability in PMVECs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Thomas Schmitz, Muriel Doret-Dion, Loic Sentilhes, Olivier Parant, Olivier Claris, Laurent Renesme, Julie Abbal, Aude Girault, Heloise Torchin, Marie Houllier, Nolwenn Le Sache, Alexandre J. Vivanti, Daniele De Luca, Norbert Winer, Cyril Flamant, Claire Thuillier, Pascal Boileau, Julie Blanc, Veronique Brevaut, Pierre-Emmanuel Bouet, Geraldine Gascoin, Gael Beucher, Valerie Datin-Dorriere, Stephane Bounan, Pascal Bolot, Christophe Poncelet, Corinne Alberti, Moreno Ursino, Camille Aupiais, Olivier Baud
Summary: Comparison between a full dose and a half dose of antenatal betamethasone for preterm delivery showed that the half dose was not non-inferior to the full dose in terms of preventing respiratory distress syndrome. Therefore, reducing the dose of antenatal betamethasone is not recommended.
Article
Computer Science, Artificial Intelligence
Longxi Zhou, Xianglin Meng, Yuxin Huang, Kai Kang, Juexiao Zhou, Yuetan Chu, Haoyang Li, Dexuan Xie, Jiannan Zhang, Weizhen Yang, Na Bai, Yi Zhao, Mingyan Zhao, Guohua Wang, Lawrence Carin, Xigang Xiao, Kaijiang Yu, Zhaowen Qiu, Xin Gao
Summary: Knowledge on long-term complications of COVID-19 is limited, especially in CT scans of survivors. A deep learning-based method was developed to calculate an optimal window for each scan and remove irrelevant tissues, making subvisual abnormalities visible in lung CT scans.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Critical Care Medicine
Jeremie Joffre, Lauren Rodriguez, Zachary A. Matthay, Elliot Lloyd, Alexander T. Fields, Roland J. Bainton, Philip Kurien, Anita Sil, Carolyn S. Calfee, Prescott G. Woodruff, David J. Erle, Carolyn Hendrickson, Matthew F. Krummel, Charles R. Langelier, Michael A. Matthay, Lucy Z. Kornblith, Judith Hellman
Summary: This study found that COVID-19 infection can lead to endothelial dysfunction and increased permeability. Additionally, factors in the patients' serum can also cause abnormalities in endothelial cell function. These findings suggest that both systemic factors acting on lung endothelial cells and viral infection of endothelial cells play a role in COVID-19-associated endotheliopathy.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Christian M. Jensen, Junia C. Costa, Jens C. Norgaard, Adrian G. Zucco, Bastian Neesgaard, Carsten U. Niemann, Sisse R. Ostrowski, Joanne Reekie, Birgit Holten, Anna Kalhauge, Michael A. Matthay, Jens D. Lundgren, Marie Helleberg, Kasper S. Moestrup
Summary: The existing chest X-ray (CXR)-based scoring systems for COVID-19 pneumonia have low spatial resolution, which needs to be increased for better evaluation of lung anatomy and severity. In this study, the MBrixia score was developed by modifying the Brixia score to improve spatial resolution. The MBrixia score, based on a rule-based quantification of CXR severity in 12 anatomical zones, was applied to CXR images of COVID-19 patients. The results showed a positive correlation between the MBrixia score and the level of respiratory support at the time of CXR imaging. The MBrixia score has the potential to serve as a quantitative surrogate measurement of COVID-19 pneumonia severity, and further research should investigate its validity and predictive capabilities for clinical outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Multidisciplinary Sciences
Lorenzo Porta, Sih-Shiang Huang, Chen Wei, Chin-Hua Su, Wan-Ting Hsu, Wang-Huei Sheng, Chien-Chang Lee
Summary: A study in Italy found that the use of methylprednisolone did not significantly reduce 30-day mortality in patients diagnosed with SARS-CoV-2. However, the use of methylprednisolone in severe patients with cardiovascular or respiratory comorbidities can reduce the incidence of shock or acute respiratory failure.
Article
Hematology
Natalia Colas-Algora, Pablo Munoz-Pinillos, Cristina Cacho-Navas, Jose Avendano-Ortiz, Gema de Rivas, Susana Barroso, Eduardo Lopez-Collazo, Jaime Millan
Summary: This study compared the responses of human lung microvascular endothelial cells to different inflammatory mediators and found that IL-6 and IL-1 beta play a major role in the pathological increase in permeability of the pulmonary microvasculature. Simultaneous inhibition of IL-1 and IL-6R can significantly alleviate the impact of cytokine storms on the pulmonary microvessels. These findings have important implications for finding the best anti-inflammatory treatments for critically ill acute respiratory distress syndrome patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)