Article
Cell Biology
Cheoljun Choi, Abhirup Saha, Seungchan An, Yoon Keun Cho, Heeseong Kim, Minsoo Noh, Yun-Hee Lee
Summary: This study found that during obesity, increased expression of Cx43 in macrophages promotes inflammatory responses in adipose tissue. Knocking out Cx43 in macrophages can reduce inflammatory responses in adipose tissue and improve glucose tolerance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joseph M. Holden, Sara Al Hussein Al Awamlh, Louis-Philippe Croteau, Andrew M. Boal, Tonia S. Rex, Michael L. Risner, David J. Calkins, Lauren K. Wareham
Summary: The nitric oxide-guanylyl cyclase-1-cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway plays an important role in controlling vascular tone and morphology. In mice lacking the alpha catalytic domain of guanylate cyclase, retinal ganglion cell degeneration occurs with age, independent of fluctuation in intraocular pressure. Dysfunctional cGMP signaling leads to changes in the neurovascular unit, affecting retinal vessel morphology and contributing to retinal neurodegeneration and loss of visual acuity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin Fang, Linfeng Nie, Satwikreddy Putluri, Nan Ni, Laurent Bartholin, Qinglei Li, Hideyuki Takeshima
Summary: Sertoli cell-specific activation of TGFBR1 leads to the formation of TGCTs in mouse testis, highlighting the important contribution of Sertoli cell reprogramming to the development of this malignancy.
Article
Environmental Sciences
Weiqi Sun, Fang Tian, Hongjie Pan, Xiuli Chang, Minjie Xia, Jingying Hu, Yuzhu Wang, Runsheng Li, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: This study systematically explored the male reproductive toxicity of FLC and found that it caused testicular dysfunction and damage in mice, leading to abnormal spermatogenesis and decreased sperm quality. The potential mechanisms include interference with spermatogonial proliferation and meiosis, as well as apoptosis and mitochondrial damage in testicular Sertoli cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Shishir Kumar Patel, Shio Kumar Singh
Summary: This study found that sustained high levels of QRFP can promote the maturation of Sertoli cells in mice testes and accelerate germ cell differentiation and formation of the seminiferous tubules.
Article
Biochemistry & Molecular Biology
Xiaomei Xie, Longjie Sun, Yixi Duan, Zheng Lv, Xiaohong Yao, Chaofan Wang, Xuexue Chen, Shuang Tian, Lu Yan, Yujing Shao, Haoshu Luo, Jiali Liu
Summary: SRSF2 plays a crucial role in supporting testis development and normal spermatogenesis. Its deficiency impairs fetal Sertoli cell proliferation, induces abnormal apoptosis and severe DNA damage, resulting in testicular dysplasia, seminiferous tubule atrophy, and infertility.
Article
Neurosciences
Ying Wang, Yizhuo Wang, Jiaming Tang, Rui Li, Yanan Jia, Hua Yang, Hongen Wei
Summary: The study demonstrated that loss of Pax2 in the nervous system leads to restricted repetitive behaviors, possibly associated with impaired neural circuitry and reduction in IGFBP2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pathology
Stephanie Siegmund, Costantino Ricci, Chia-Sui Kao, Ankur R. Sangoi, Sambit Mohanty, Christopher D. M. Fletcher, Maurizio Colecchia, Andres M. Acosta
Summary: This study suggests that germline APC alterations may predispose to testicular sex cord-stromal tumors (TSCSTs), including Sertoli cell tumors. APC variants, leading to gene inactivation, were found to be the likely oncogenic driver in these tumors.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiyeon Ham, Whasun Lim, Gwonhwa Song
Summary: Flufenoxuron is a benzoylurea pesticide used to eradicate insects and acarids in farmland, with potential harmful effects on non-target animals through bioaccumulation. Studies have shown that flufenoxuron inhibits cell proliferation, disrupts calcium homeostasis, and induces testicular dysfunction in mice. Additionally, it may activate certain signaling pathways in cells and alter gene expression related to male reproduction.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yibo Wu, Cong Shen, Tiantian Wu, Xiaoyan Huang, Hong Li, Bo Zheng
Summary: This study discovered the expression of STXBP2 in Sertoli cells and investigated its function in the testes. The results revealed the important role of STXBP2 in Sertoli cell migration and germ cell survival, and its interaction with connexin 43 in regulating its expression.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Manuel Rattka, Soeren Westphal, Bernd M. Gahr, Steffen Just, Wolfgang Rottbauer
Summary: The study revealed a crucial role of Spen in controlling cardiac function in zebrafish embryos, with Spen deficiency leading to impaired cardiac function and abnormal rhythms. The findings also demonstrate the importance of the Spen-Cx43 axis in regulating heart function and suggest potential therapeutic targets for cardiac disorders.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Immunology
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Goetz, Jun-ichi Kira
Summary: By knocking out the Cx43 gene in astroglia, EAE clinical symptoms can be alleviated, reducing inflammation cell infiltration and demyelination in the spinal cord, meanwhile promoting anti-inflammatory gene expression and inhibiting proinflammatory gene expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Summary: This study reveals a novel mechanism of the GJ-Cx43-mediated astrocytic network involved in isoflurane-induced neuroinflammation and cognitive impairments, which provides new mechanistic insight into the pathogenesis of POCD and identifies potential targets for its treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Cai Qing, Zhao Xinyi, Yu Xuefei, Xue Xindong, Fu Jianhua
Summary: Bronchopulmonary dysplasia (BPD) is a common devastating pulmonary complication in preterm infants, characterized by alveolar maldevelopment associated with oxidative stress and excessive apoptosis. Gap26, a connexin 43-inhibiting peptide, has been shown to improve alveolar development by inhibiting intercellular communication in BPD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Haochuan Zhang, Yiting Zhu, Chengli Jin, Lingxin Shi, Ying Xie, Xinyi Sun, Peizhen Li, Xinyi Zhu, Quanquan Dai, Fan Yang, Xiaoxiao Xie, Le Qin
Summary: This study investigated the mechanism of testis injury after testicular torsion detorsion (T/D) and the role of the Oct4-CIP2A axis in testis protection. The expression of CIP2A and Oct4 was downregulated in T/D mice. Upregulation of Oct4 restored CIP2A expression and ameliorated testicular damage caused by torsion. T/D treatment increased serum anti-sperm antibody levels, reduced testosterone levels, and promoted oxidative stress, while Oct4 restoration partially counteracted these effects.
Article
Biochemistry & Molecular Biology
D. Fietz, M. Markmann, D. Lang, L. Konrad, J. Geyer, S. Kliesch, T. Chakraborty, H. Hossain, M. Bergmann
BMC MOLECULAR BIOLOGY
(2015)
Article
Urology & Nephrology
Adrian Pilatz, Hamid Hossain, Rolf Kaiser, Annette Mankertz, Christian G. Schuettler, Eugen Domann, Hans-Christian Schuppe, Trinad Chakraborty, Wolfgang Weidner, Florian Wagenlehner
Article
Microbiology
Tobias Eisenberg, Christoph Hudemann, Hamid M. Hossain, Angela Hewer, Khodr Tello, Dirk Bandorski, Manfred Rohde, Peter Valentin-Weigand, Christoph Georg Baums
JOURNAL OF CLINICAL MICROBIOLOGY
(2015)
Article
Genetics & Heredity
Anne Hilgendorff, Anita Windhorst, Manuel Klein, Svetlin Tchatalbachev, Christine Windemuth-Kieselbach, Joachim Kreuder, Matthias Heckmann, Anna Gkatzoflia, Harald Ehrhardt, Josef Mysliwietz, Michael Maier, Benjamin Izar, Andre Billion, Ludwig Gortner, Trinad Chakraborty, Hamid Hossain
JOURNAL OF MOLECULAR MEDICINE-JMM
(2017)
Article
Respiratory System
Peter Ahnert, Petra Creutz, Markus Scholz, Hartwig Schuette, Christoph Engel, Hamid Hossain, Trinad Chakraborty, Michael Bauer, Michael Kiehntopf, Uwe Voelker, Sven Hammerschmidt, Markus Loeffler, Norbert Suttorp
BMC PULMONARY MEDICINE
(2016)
Article
Andrology
A. Pilatz, C. Hudemann, J. Wolf, I. Halefeld, A. Paradowska-Dogan, H. -C. Schuppe, H. Hossain, Q. Jiang, D. Schultheiss, H. Renz, W. Weidner, F. Wagenlehner, T. Linn
Article
Medicine, General & Internal
Andre Scherag, Franziska Schoeneweck, Miriam Kesselmeier, Stefan Taudien, Matthias Platzer, Marius Felder, Christoph Sponholz, Anna Rautanen, Adrian V. S. Hill, Charles J. Hinds, Hamid Hossain, Norbert Suttorp, Oliver Kurzai, Hortense Slevogt, Evangelos J. Giamarellos-Bourboulis, Apostolos Armaganidis, Evelyn Trips, Markus Scholz, Frank M. Brunkhorst
Article
Immunology
Ming Wang, Monika Fijak, Hamid Hossain, Melanie Markmann, Rolf M. Nuesing, Guenter Lochnit, Michaela F. Hartmann, Stefan A. Wudy, Lizong Zhang, Huanpeng Gu, Lutz Konrad, Trinad Chakraborty, Andreas Meinhardt, Sudhanshu Bhushan
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Adrian Pilatz, Thomas Discher, Guenter Lochnit, Julia Wolf, Hans-Christian Schuppe, Christian G. Schuettler, Hamid Hossain, Wolfgang Weidner, Juergen Lohmeyer, Thorsten Diemer
Article
Obstetrics & Gynecology
Adrian Pilatz, Guenter Lochnit, Srikanth Karnati, Agnieszka Paradowska-Dogan, Tali Lang, Dirk Schultheiss, Hans-Christian Schuppe, Hamid Hossain, Eveline Baumgart-Vogt, Wolfgang Weidner, Florian Wagenlehner
FERTILITY AND STERILITY
(2014)
Article
Andrology
Adrian Pilatz, Jill Kilb, Huelya Kaplan, Daniela Fietz, Hamid Hossain, Christian G. Schuettler, Thorsten Diemer, Martin Bergmann, Eugen Domann, Wolfgang Weidner, Florian Wagenlehner, Hans-Christian Schuppe
Review
Public, Environmental & Occupational Health
Stefanie Boehm, Katharina vom Berge, Daniela Hierhammer, Daniela Jacob, Roland Grunow, Julia M. Riehm, Regina Konrad, Marc Dauer, Berit Bouschery, Hamid Hossain, Elisabeth Schichtl, Merle M. Boehmer
Summary: In November 2018, a tularaemia outbreak occurred in Bavaria, Germany, among participants of a hare hunt and butchery employees handling the hares. The investigation revealed that infection mainly occurred in hunting participants present while hares were processed, with the highest risk of infection for those directly involved in the activities. Promoting and increasing appropriate use of personal protective equipment among people processing hares is crucial to prevent future outbreaks.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Critical Care Medicine
Peter Ahnert, Petra Creutz, Katrin Horn, Fabian Schwarzenberger, Michael Kiehntopf, Hamid Hossain, Michael Bauer, Frank Martin Brunkhorst, Konrad Reinhart, Uwe Voelker, Trinad Chakraborty, Martin Witzenrath, Markus Loeffler, Norbert Suttorp, Markus Scholz, Stefan Angermair, Arntzen Christoph, Krankenhaus Angermuende, Lorenz Balke, Bals Robert, Benzke Michael, Berber Ayhan, Bloos Frank, Buchenroth Martin, Deterding Lea, Dickgreber Nicolas, Dmitriev Oleg, Druckmiller Hermann, Flick Holger, Foellmer Ulrike, Freise Julia, Garcia Carmen, Glaeser Sven, Grah Christian, Hamberger Simone, Hartung Karsten, Hauptmeier Barabara, Held Matthias, Hempel Frederik, Hering Iris, Hobler Carola, Hocke Andreas, Hoffmann Ursula, Kahnert Henning, Kanwar Oliver, Kappauf Lena, Keller Charlotte, Keller Nils, Knueppel Walter, Koch Eva, Kolditz Martin, Krollmann Christine, Kropf-Sanchen Cornelia, Lehmke Josefa, Lensch Christian, Liebrich Andreas, Lies Achim, Ludewig Katrin, Makowski Lena-Maria, Mayer Phillipp, Mayer Brigitte, Mikolajewska Agata, Moeser Anne, Mueller Thomas, Niesen Markus, Oqueka Tim, Pankow Wulf, Pannier Judith, Peckelsen Claus, Plauth Mathias, Pletz Mathias, Pluta Jan, Popkirova Kalina, Rademacher Jessica, Ramke Mirja, Rosenow Felix, Ruediger Stefan, Ruf Bernhard, Rupp Jan, Schaaf Bernhard, Schaberg Tom, Schelle Marianne, Schmidt-Schridde Patrick, Schott Galina, Schroeder Barbara, Shchetynska-Marinova Tetyana, Simpfendoerfer Michael, Spinner Thomas, Suttorp Norbert, Thiemig Dorina, Thomas-Rueddel Daniel, Wagener Barbara, Wakonigg Gudrun, Wehde Deborah, Wirtz Hubert
Review
Medicine, General & Internal
Hans-Christian Schuppe, Adrian Pilatz, Hamid Hossain, Thorsten Diemer, Florian Wagenlehner, Wolfgang Weidner
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2017)
Article
Urology & Nephrology
F. Wagenlehner, A. Pilatz, T. Linn, T. Diemer, H. C. Schuppe, U. Schagdarsurengin, H. Hossain, A. Meinhardt, S. Ellem, G. Risbridger, W. Weidner
MINERVA UROLOGICA E NEFROLOGICA
(2013)