Article
Biochemistry & Molecular Biology
Megan Leask, Catherine Carleton, Bryony Leeke, Trent Newman, Joseph Antoun, Mauro Farella, Julia Horsfield
Summary: This study explores the impact of oxidative stress on neural crest cells, leading to craniofacial abnormalities, and tests the therapeutic effect of antioxidants on these effects, suggesting that antioxidants may potentially prevent defects in craniofacial cartilage.
Article
Nutrition & Dietetics
Igor Pravst, Ziva Lavrisa, Masa Hribar, Hristo Hristov, Naska Kvarantan, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Katja Zmitek, Anita Kusar
Summary: Folate deficiency is common in Slovenia, with low folate intake observed in various age groups. Public health strategies are needed to promote the consumption of folate-rich foods and supplementation with folic acid may be necessary in specific vulnerable populations.
Article
Biochemistry & Molecular Biology
Tao Li, Xiaofei Weng, Siya Cheng, Dongxing Wang, Guanchang Cheng, Hai Gao, Yanming Li
Summary: The study found that in TGFβ1-induced cardiac hypertrophy, the Wnt/beta-catenin signaling pathway is activated, which is associated with the expression of c-Myc and the upregulation of Wnt3a.
Article
Multidisciplinary Sciences
Ruimin Liu, Yinying Han, Chenglong Huang, Mengqian Hou, Rui Cheng, Shujin Wang, Xi Li, Jie Tian
Summary: This study aimed to investigate the potential roles of adipokine chemerin on high fat-induced cardiac dysfunction. Chemerin supplementation reversed the lipid-induced abnormalities in lipid-overload cardiomyocytes. Adipocyte-derived chemerin might function as an endogenous cardioprotective factor against obese-related cardiomyopathy.
Article
Nutrition & Dietetics
Carmen Morais-Moreno, Ana M. Montero-Bravo, Ana M. Puga, Ma de Lourdes Samaniego-Vaesken, Mar Ruperto, Rocio Marco Mendez, Alvaro Vicente-Arche, Gregorio Varela-Moreiras, Teresa Partearroyo
Summary: Noise-induced hearing loss is a common and preventable occupational disease. Aviation pilots, who spend a lot of time exposed to noise pollution, are particularly vulnerable. This study found that flight hours, serum folate, and homocysteine levels were significantly related to hearing loss in pilots.
Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.
Article
Nutrition & Dietetics
Rihwa Choi, Wonseo Park, Gayoung Chun, Sang Gon Lee, Eun Hee Lee
Summary: We investigated the prevalence of folate deficiency and associated factors in a large population of Korean women of reproductive age during the COVID-19 pandemic. Our study highlights the importance of understanding the prevalence and factors related to folate deficiency for planning nutritional support programs in Korea.
Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Public, Environmental & Occupational Health
Derrick A. Bennett, Sarah Parish, Iona Y. Millwood, Yu Guo, Yiping Chen, Iain Turnbull, Ling Yang, Jun Lv, Canqing Yu, George Davey Smith, Yongjun Wang, Yilong Wang, Richard Peto, Rory Collins, Robin G. Walters, Liming Li, Zhengming Chen, Robert Clarke
Summary: In Chinese adults, the MTHFR C677T polymorphism is associated with an increased risk of stroke, highlighting the importance of further trials involving folic acid and mandatory folic acid fortification programs for stroke prevention in low-folate populations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lyazzat Kaldygulova, Talshyn Ukybassova, Gulzhanat Aimagambetova, Andrey Gaiday, Akylbek Tussupkaliyev
Summary: The rationale and importance of folic acid supplementation during pregnancy for preventing fetal congenital defects are widely accepted. Adequate folate levels can reduce the risk of spontaneous abortions and support normal placental blood flow, promoting appropriate fetal growth. Additionally, there is emerging evidence that long-term folic acid supplementation can effectively prevent preeclampsia, a complication unique to humans during pregnancy that contributes to worldwide maternal and perinatal mortality. Folate supplementation helps to decrease elevated levels of homocysteine, which is associated with the risk of preeclampsia.
Article
Nutrition & Dietetics
Paulina Maria Przybycien-Gaweda, Tih Shih Lee, Wee Shiong Lim, Mei Sian Chong, Philip Yap, Chin Yee Cheong, Iris Rawtaer, Tau Ming Liew, Xinyi Gwee, Qi Gao, Keng Bee Yap, Tze Pin Ng
Summary: There is a lack of evidence supporting the association between folate and vitamin B12 exposure with cognitive outcomes. However, this study found that low vitamin B12 levels, high homocysteine levels, and a hypo-methylation one-carbon index are significantly associated with the progression to neurocognitive disorder among cognitively-normal adults.
Review
Genetics & Heredity
Melissa Roufael, Tania Bitar, Yonna Sacre, Christian Andres, Walid Hleihel
Summary: Autism Spectrum Disorder (ASD) has seen a rapid increase in incidence and disturbances in folate or methionine metabolism have been found in individuals with ASD. Changes in metabolite concentrations associated with this cycle could be potential biomarkers and therapeutic targets for ASD. High levels of homocysteine and low levels of vitamins B12 and folate, influenced by poor diet and genetic predispositions, have been linked to ASD. Nutritional supplements have shown potential benefits for treating ASD, but more research is needed.
Article
Food Science & Technology
Anna M. Malinowska, Marcin Schmidt, Dieuwertje E. Kok, Agata Chmurzynska
Summary: This study aimed to evaluate the relationship between lifestyle factors and the production of folates by gut microbiota, as well as the association between this potential and folate and tHcy levels in humans. The results showed that gut microbiota has the ability to synthesize folates, but this capacity does not predict human folate status.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Winner Kucha, Daniel Seifu, Abenezer Tirsit, Mahlet Yigeremu, Markos Abebe, Dawit Hailu, Dareskedar Tsehay, Solomon Genet
Summary: The study found that deficiency in folate and vitamin B12 in the blood of pregnant women may be associated with neural tube defects. There is a correlation between the use of folate/multivitamins and neural tube defects.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Muhammad Shabir Khan, Anum Saeedullah, Simon C. Andrews, Khalid Iqbal, Syed Abdul Qadir, Babar Shahzad, Zahoor Ahmed, Muhammad Shahzad
Summary: This study investigated the prevalence and associated risk factors for hyperhomocysteinemia among adolescent Afghan refugees aged 10-19 years. The study found a high prevalence of hyperhomocysteinemia (25%) among the participants, with boys having higher homocysteine levels than girls. Serum levels of vitamin B12 and folate were significantly associated with hyperhomocysteinemia.