Article
Medicine, General & Internal
Monika Kamianowska, Aleksandra Kamianowska, Mateusz Maciejczyk, Anna Kurowska, Bozena Blazewicz, Agnieszka Maria Rogowska, Anna Wasilewska
Summary: This study analyzed the concentrations of renal biomarkers (osteopontin, cystatin C, and NGAL) in neonates and found that prematurity may lead to increased excretion of osteopontin and cystatin C, but not NGAL. The excretion of NGAL and cystatin C may change during the first weeks of a premature neonate's life, but osteopontin does not.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Izabela Duda, Lukasz Krzych
Summary: The study demonstrated that plasma NGAL, combined with indices of critical illness, is a useful biomarker for predicting mortality in heterogeneous population of ICU patients. pNGAL on D3 was found to be the most suitable for predicting in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Agriculture, Dairy & Animal Science
Stine Jacobsen, Camilla Drejer Mortensen, Elisabeth Alkaersig Hoj, Anne Mette Vinther, Lise Charlotte Berg, Ditte Marie Top Adler, Denis Verwilghen, Gaby van Galen
Summary: Early detection of joint infection in horses is crucial for preventing further damage and ensuring proper treatment. The biomarker NGAL has proven to be highly accurate in diagnosing joint infection in horses and monitoring treatment response. NGAL measurements may enable early detection and prompt therapy initiation, improving prognosis for horses with joint infection.
Review
Medical Laboratory Technology
Vijaya Marakala
Summary: NGAL can be a valuable biomarker for the early detection of acute kidney injury and other kidney-related diseases, and has predictive value in predicting outcomes and severity.
CLINICA CHIMICA ACTA
(2022)
Article
Multidisciplinary Sciences
Marcos Antonio Marton Filho, Rodrigo Leal Alves, Paulo do Nascimento Junior, Gabriel dos Santos Tarquinio, Paulo Ferreira Mega, Norma Sueli Pinheiro Modolo
Summary: In laparoscopic cholecystectomy, increased intra-abdominal pressure leads to elevation of NGAL and cystatin C levels intraoperatively, while the use of low-pressure pneumoperitoneum does not alter the course of these biomarkers.
Article
Urology & Nephrology
Stuart L. Goldstein, Kelli A. Krallman, Cassie Kirby, Jean-Philippe Roy, Michaela Collins, Kaylee Fox, Alexandra Schmerge, Sarah Wilder, Bradley Gerhardt, Ranjit Chima, Rajit K. Basu, Lakhmir Chawla, Lin Fei
Summary: Acute kidney injury is common among children and young adults admitted to the pediatric intensive care unit, and severe acute kidney injury is associated with mortality. The integration of renal angina index and urine NGAL improves the prediction of severe acute kidney injury.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Perihan Uelger, Ebru Yildiz, Bartosz Tyczynski, Hajo Findeisen, Andreas Kribben, Onno E. Janssen, Stefan Herget-Rosenthal
Summary: The study aimed to investigate the relationship between stress hyperglycemia (SH) and acute kidney injury (AKI) in non-diabetic critically ill patients. It found that SH was a risk factor for subsequent AKI, and the combination of high blood glucose levels and tubular injury increased the likelihood of AKI development. These findings suggest the importance of monitoring and managing blood glucose levels in critically ill patients to prevent AKI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medical Laboratory Technology
Zhimin Huang, Lin Wu, Ming Zeng, Buyun Wu, Xueqiang Xu, Huijuan Mao, Yanggang Yuan, Changying Xing
Summary: This study aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). The results showed that urinary NGAL (uNGAL) levels were significantly higher in the AKI group compared to the CKD group, while serum NGAL (sNGAL) levels were not significantly different. Furthermore, the u/s NGAL ratio and fractional excretion of NGAL (Fe NGAL) were able to effectively distinguish AKI from CKD. Further confirmatory studies are still necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, General & Internal
Dina Midan, Fady El-Gendy, Dalia Abo ELAlla, Mayada Kotb
Summary: Sepsis is a life-threatening condition in neonates, and its diagnosis is challenging. This study evaluated the diagnostic performance of NGAL as a biomarker for early detection of neonatal sepsis. NGAL levels showed significant differences between sepsis cases and controls, and were significantly higher in non-survivors. NGAL demonstrated strong discriminatory power and could potentially serve as a promising diagnostic marker for neonatal sepsis.
ANNALS OF MEDICINE
(2022)
Review
Physiology
Stephanie Guardado, Daniel Ojeda-Juarez, Marcus Kaul, Tara M. Nordgren
Summary: Lipocalin-2 (LCN2) functions as an inflammatory mediator with roles in immune response, iron sequestration, cell migration, and apoptosis regulation. Research aims to differentiate between the protective and detrimental roles of LCN2 in immune response to various inflammatory stimuli.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Moli Yin, Yuanwang Nie, Hao Liu, Lei Liu, Lu Tang, Yuan Dong, Chuanmin Hu, Huiyan Wang
Summary: A rapid and accurate method for detecting NGAL in urine specimens has been established based on europium nanoparticles, providing important evidence for the early diagnosis of acute kidney injury.
Article
Pharmacology & Pharmacy
S. Chraibi, R. Rosiere, E. De Prez, M. H. Antoine, M. Remmelink, I Langer, J. Nortier, K. Amighi, N. Wauthoz
Summary: The study aimed to evaluate the pulmonary and renal tolerance of cisplatin controlled-release dry powder for inhalation (CIS-DPI) and intravenous cisplatin (CIS-IV) as monotherapies, and to optimize their combination in terms of dose and schedule. Combining CIS-DPI and CIS-IV at the maximum tolerated dose impaired pulmonary and renal tolerance. However, improving pulmonary tolerance was achieved by decreasing the CIS-IV dose by 25% while maintaining the MTD for CIS-DPI, along with a 24-hour delay between CIS-DPI and CIS-IV administrations to limit acute kidney injury.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, General & Internal
Yuwei Yang, Bin Ge, Yan Liu, Jiafu Feng
Summary: This study investigates the roles of NGAL, CysC, and sCr in diagnosing AKI secondary to liver cirrhosis. Results suggest that NGAL may outperform sCr and CysC, with uNGAL being a more reliable indicator for diagnosing AKI.
Article
Cardiac & Cardiovascular Systems
Yuxue Huang, Ning Zhang, Cuiping Xie, Yayu You, Lei Guo, Feiming Ye, Xiaojie Xie, Jian'an Wang
Summary: This study found that LCN2 deficiency prevented sepsis-induced cardiac dysfunction and ferroptosis, and suggested that neutrophil-derived LCN2 might be a potential therapeutic target for SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)