Article
Clinical Neurology
Pargol Balali, Robert G. Hart, Eric E. Smith, Feryal Saad, Pablo Colorado, Robin Lemmens, Gian Marco De Marchis, Valeria Caso, Lizhen Xu, Laura Heenan, Stuart J. Connolly, Hardi Mundl, Ashkan Shoamanesh
Summary: This study aimed to investigate the effects of the factor-XIa inhibitor asundexian on the development of new microbleeds in non-cardioembolic ischemic stroke patients. The results showed that asundexian treatment was not associated with the development of microbleeds and had a lower occurrence of adverse outcomes such as new microbleeds and hemorrhagic transformation in patients with microbleeds.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Neurosciences
Ruoyao Cao, Yao Lu, Peng Qi, Yanyan Wang, Hailong Hu, Yun Jiang, Min Chen, Juan Chen
Summary: The study aimed to validate the value of collateral circulation and B-type natriuretic peptide (BNP) in predicting clinical outcomes in patients with acute ischemic stroke (AIS) and their biomarker value for stroke subtypes before endovascular treatment (EVT). The results showed that the modified collateral circulation scoring system on four-dimensional computed tomography angiography (4D CTA-CS) and BNP could be independent predictors of clinical outcomes in AIS patients and determine stroke subtypes. The combination of BNP and 4D CTA-CS had the highest predictive value compared to collateral status or BNP alone.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Cardiac & Cardiovascular Systems
Peter U. Heuschmann, Felipe A. Montellano, Kathrin Ungethuem, Viktoria Ruecker, Silke Wiedmann, Daniel Mackenrodt, Anika Quilitzsch, Timo Ludwig, Peter Kraft, Judith Albert, Caroline Morbach, Stefan Frantz, Stefan Stork, Karl Georg Haeusler, Christoph Kleinschnitz
Summary: The study found a significant proportion of patients with acute ischemic stroke (IS) exhibited subclinical and clinical cardiac dysfunction, including systolic dysfunction (SD), diastolic dysfunction (DD), and clinically overt heart failure (HF).
Article
Cardiac & Cardiovascular Systems
Moritake Iguchi, Takao Kato, Hidenori Yaku, Takeshi Morimoto, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yasuhiro Hamatani, Yugo Yamashita, Nobutoyo Masunaga, Hisashi Ogawa, Mitsuru Ishii, Yoshimori An, Ryoji Taniguchi, Masashi Kato, Mamoru Takahashi, Toshikazu Jinnai, Tomoyuki Ikeda, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mitsunori Kawato, Yuta Seko, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Mitsuru Abe, Masaharu Akao, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: During hospitalization for acute decompensated heart failure, 1.6% of patients developed ischemic stroke. Men, ACS, absence of prior heart failure hospitalization, and high BNP/NT-proBNP levels at admission were independently associated with ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Sara Rodriguez-Martin, Diana Barreira-Hernandez, Ramon Mazzucchelli, Miguel Gil, Alberto Garcia-Lledo, Laura Izquierdo-Esteban, Ana Perez-Gomez, Antonio Rodriguez-Miguel, Francisco J. De Abajo
Summary: In this case-control study, the use of oral bisphosphonates was found to specifically increase the risk of cardioembolic ischemic stroke, but had little effect on non-cardioembolic stroke. The duration of bisphosphonate use and the interaction with calcium supplements and anticoagulants were also observed to play a role. These findings have important implications for clinical practice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ruoyao Cao, Yun Jiang, Ling Li, Yao Lu, Junjie Wang, Kezhen Yu, Min Chen, Juan Chen
Summary: The potential roles of B-type natriuretic peptide (BNP) and imaging markers in distinguishing cardioembolic (CE) stroke from non-CE stroke were investigated. The study found that BNP and mismatch ratio (MMR) were independent predictive factors of CE stroke, and BNP was correlated with various imaging parameters. The combination of BNP and MMR improved the predictive value for CE stroke.
Article
Pharmacology & Pharmacy
Patrick P. Komane, Pradeep Kumar, Yahya E. Choonara
Summary: Functionalized carbon nanotubes with dexamethasone can significantly reduce atrial natriuretic peptide levels, potentially reducing inflammation in ischemic stroke-induced rats and leading to successful treatment.
Article
Genetics & Heredity
Ming Li, Yi Xu, Jiaqi Wu, Chuanjie Wu, Ang Li, Xunming Ji
Summary: Mendelian randomization was used to investigate the causal association between NT-proBNP levels and ischemic stroke. The analysis found no significant association between NT-proBNP levels and ischemic stroke or its subtypes, except for a suggestive association with large-artery atherosclerosis stroke. Furthermore, the study suggests that NT-proBNP levels may reduce the risk of small-vessel occlusion stroke. These findings provide important insights into the pathophysiology and treatment of ischemic stroke.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Beyza Muhsine Arslan, Murat Cabalar, Nilgun Isiksacan, Vildan Yayla
Summary: This study assessed the levels of NT-proBNP in patients with acute ischemic stroke and its relationship with clinical outcomes. The results showed that NT-proBNP levels were higher in patients with atrial fibrillation and cardioembolic stroke, and were positively correlated with short-term clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Juliane Schweizer, Markus Arnold, Inke R. Koenig, Antonela Bicvic, Laura P. Westphal, Valerie Schuetz, Corinne Inauen, Natalie Scherrer, Andreas Luft, Marian Galovic, Carolina Ferreira Atuesta, Thomas Pokorny, Marcel Arnold, Urs Fischer, Leo H. Bonati, Gian Marco De Marchis, Timo Kahles, Krassen Nedeltchev, Carlo W. Cereda, Georg Kaegi, Alejandro Bustamante, Joan Montaner, Georg Ntaios, Dimitrios Sagris, Christian Foerch, Katharina Spanaus, Arnold von Eckardstein, Mira Katan
Summary: This study demonstrates that midregional pro-atrial natriuretic peptide (MR-proANP) can be used to differentiate the etiology of acute ischemic stroke, identify newly diagnosed atrial fibrillation, and assess the risk of major adverse cardiovascular events. MR-proANP levels are associated with atrial fibrillation and cardiovascular events and can be used as a decision tool for prolonged cardiac monitoring in stroke patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Leonardo De Luca, Elisa Bellettini, Dario Di Maio, Enrico Natale, Rita Lucia Putini, Sabrina Anticoli, Furio Colivicchi, Paolo Calabro, Francesco Musumeci, Domenico Gabrielli
Summary: Stroke is the leading cause of disability and mortality worldwide. Antiplatelet therapy plays a key role in managing stroke/TIA complications. Aspirin, clopidogrel, and ticagrelor are the most commonly discussed and used antiplatelet therapies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Han-Gil Jeong, Beom Joon Kim, Tackeun Kim, Jihoon Kang, Jun Yup Kim, Joonghee Kim, Joon-Tae Kim, Jong-Moo Park, Jae Guk Kim, Jeong-Ho Hong, Kyung Bok Lee, Tai Hwan Park, Dae-Hyun Kim, Chang Wan Oh, Moon-Ku Han, Hee-Joon Bae
Summary: A deep convolutional neural network, ASTRO-X, was developed to diagnose cardioembolic stroke based on chest radiographs. The network demonstrated good classification performance in internal and multicentre external testing, focusing on the region where the left atrium was located. Predictions of cardioembolism by ASTRO-X correlated with higher left atrial volume index and lower left ventricular ejection fraction in echocardiography.
Article
Multidisciplinary Sciences
Phattheera Srisujikul, Kitti Thiankhaw, Surat Tanprawate, Atiwat Soontornpun, Chayasak Wantaneeyawong, Chutithep Teekaput, Nopdanai Sirimaharaj, Angkana Nudsasarn
Summary: This study investigated the association between serum NT-proBNP levels and functional outcomes in acute ischemic stroke patients. The results showed that elevated NT-proBNP levels were associated with unfavorable functional outcomes, suggesting that NT-proBNP may be a useful biomarker for predicting prognosis after ischemic stroke.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Masayuki Shiba, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Yuta Seko, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Takeshi Kimura
Summary: This study investigated the association between changes in brain natriuretic peptide (BNP) levels and clinical outcomes in patients with acute heart failure (AHF). The results showed that the percent change in BNP was associated with an increased risk of all-cause death or hospitalization for HF. Therefore, monitoring changes in BNP levels can help in the management of patients with heart failure.
Article
Clinical Neurology
R. Gutierrez-Zuniga, M. Alonso de Lecinana, R. Delgado-Mederos, J. Gallego-Cullere, M. Rodriguez-Yanez, M. Martinez-Zabaleta, M. Freijo, J. C. Portilla, A. Gil-Nunez, J. Diez Sebastian, A. Lisbona, E. Diez-Tejedor, B. Fuentes
Summary: This study aimed to assess the effect of glycemic variability (GV) on acute ischemic stroke progression. The study found that higher GV values during the first 48 hours after stroke were associated with mortality. Subcutaneous insulin treatment may be associated with higher levels of GV.
Article
Clinical Neurology
Marta Olive-Gadea, Natalia Perez de la Ossa, Tudor Jovin, Sonia Abilleira, Xavier Jimenez, Pere Cardona, Angel Chamorro, Alan Flores, Yolanda Silva, Francesc Purroy, Joan Marti-Fabregas, Ana Rodriguez-Campello, Josep Zaragoza, Jerzy Krupinski, David Canovas, Manuel Gomez Choco, Natalia Mas, Ernest Palomeras, Dolores Cocho, Josep M. Aragones, Carmen Repullo, Eduard Sanjurjo, Dolores Carrion, Esther Catena, Xavier Costa, M. Cruz Almendros, Miquel Barcelo, Jordi Monedero, Maria Rybyeva, Gloria Diaz, Marc Ribo
Summary: During the RACECAT trial, there was an increase in EVT rates and a significant decrease in workflow times in the Local-SC regions.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Mikel Terceno, Yolanda Silva, Saima Bashir, Angel Chamorro, Natalia Perez de la Ossa, Maria Hernandez-Perez, Carlos Castano, Pol Camps-Renom, Denisse Wenger, Pere Cardona, Carlos Molina, Ana Rodriguez-Campello, David Canovas, Francisco Purroy, Merce Salvat-Plana, Joaquin Serena
Summary: This study aimed to investigate the impact of FPE in patients with PC-LVO. The results showed that FPE was associated with functional independence and had better treatment outcomes compared to MPE. The use of direct aspiration, embolic mechanism of stroke, and absence of general anesthesia were identified as independent predictors of FPE.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jose Dopico, Joao Botelho, Alberto Ouro, Clara Dominguez, Vanessa Machado, Marta Aramburu-Nunez, Antia Custodia, Teresa Blanco, Maria Vazquez-Reza, Daniel Romaus-Sanjurjo, Juan Blanco, Rogelio Leira, Tomas Sobrino, Yago Leira
Summary: This study found that patients with periodontitis had higher expression of TLRs, cFN, and IL-6, which were associated with the occurrence of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Artur Filipe Rodrigues, Ana P. M. Tavares, Susana Simoes, Rui P. F. F. Silva, Tomas Sobrino, Bruno R. Figueiredo, Goreti Sales, Lino Ferreira
Summary: Graphene-based materials (GBMs) have been explored for developing flexible interfaces to treat neurological disorders by improving brain function and tissue regeneration through electrical stimulation. Recent findings of GBM electrodes generating electrical response under light exposure have inspired the development of non-genetic approaches, such as optogenetics, to selectively modulate brain cells. In this study, graphene was conjugated with upconversion nanoparticles (UCNPs) to enable wireless transcranial activation using near-infrared (NIR) radiation. The optimized UCNP formulations attached to graphene nanoplatelets showed enhanced electrical conductivity upon NIR activation, promoting cell proliferation and downregulating neuronal and glial differentiation markers in human neuroblastoma cells.
Editorial Material
Cell Biology
Daniel Romaus-Sanjurjo, Antia Custodia, Alberto Ouro, Tomas Sobrino
NEURAL REGENERATION RESEARCH
(2023)
Review
Clinical Neurology
Kori S. Zachrison, Victoria M. Nielsen, Natalia Perez de la Ossa, Tracy E. Madsen, Rebecca E. Cash, Remle P. Crowe, Erika C. Odom, Edward C. Jauch, Opeolu M. Adeoye, Christopher T. Richards
Summary: Prehospital factors play a critical role in acute stroke care and patient outcomes. This review discusses the current state of prehospital components of stroke systems of care, including layperson recognition of stroke, transport strategies, networked care, data integration, and inequities within systems.
Article
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodriguez-Yanez, Iria Lopez-Dequidt, Jose M. Pumar, Antonio J. Mosqueira, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: The circadian system has an influence on body temperature and stroke onset. This study explores the impact of temperature chronobiology on stroke onset and functional outcomes, as well as the variation of blood biomarkers based on stroke onset time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Mattia Gallizioli, Maria Arbaizar-Rovirosa, David Brea, Anna M. Planas
Summary: Aging is associated with progressive changes in cellular and tissue functions, particularly through the vascular and immune systems. These changes increase the risk and worsen the outcome of stroke. The hallmarks of aging, such as chronic inflammation and immunometabolic disturbances, are also involved in the cerebral response to stroke. Aging reduces the ability to control these responses, leading to increased inflammation, metabolic dysregulation, and impaired waste disposal. Additionally, aging-related diseases and alterations in gut microbiota composition further exacerbate these effects and increase the risk of post-stroke infection. Advances in aging research may offer potential strategies to improve stroke outcomes in the elderly.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Cell Biology
Antia Custodia, Marta Aramburu-Nunez, Marina Rodriguez-Arrizabalaga, Juan Manuel Pias-Peleteiro, Laura Vazquez-Vazquez, Javier Camino-Castineiras, Jose Manuel Aldrey, Jose Castillo, Alberto Ouro, Tomas Sobrino, Daniel Romaus-Sanjurjo
Summary: Alzheimer's disease (AD) is the most common degenerative disorder in developed countries among the elderly, and growing evidence suggests that endothelial dysfunction plays a key role in the cognitive decline associated with AD. Dysfunction of endothelial cells, which are a crucial component of the blood-brain barrier (BBB), allows the passage of toxic substances to the brain, resulting in chronic hypoperfusion and an inflammatory response. This disruption of the BBB, along with astrogliosis, leads to neuronal degeneration and may contribute to cognitive deterioration. New molecules have been identified as potential early biomarkers for endothelial dysfunction, providing new therapeutic targets and diagnostic markers for AD.
Article
Cell Biology
Susanna Kemppainen, Nadine Huber, Roosa-Maria Willman, Ana Zamora, Petra Makinen, Henna Martiskainen, Mari Takalo, Annakaisa Haapasalo, Tomas Sobrino, Manuel Antonio Gonzalez Gomez, Yolanda Pineiro, Jose Rivas, Uwe Himmelreich, Mikko Hiltunen
Summary: Organotypic slice culture models, especially those derived from adult tissue, provide a valuable tool for studying neurodegenerative diseases such as tauopathies. In this study, hippocampal slice cultures from adult transgenic mice were used to investigate the effects of a novel antibody on hyperphosphorylated TAU. The adult-originating slices retained key cellular components and exhibited tau pathology, making them a suitable model for studying TAU pathology in the adult brain without the interference of the blood-brain barrier.
Review
Neurosciences
David Brea
Summary: This article discusses the impact of stroke on the immune system, highlighting the initial inflammatory response followed by subsequent immunosuppression, which significantly affects patients.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Nursing
Carlos Rodriguez-Abad, Alba-Elena Martinez-Santos, Josefa-del-Carmen Fernandez-de-la-Iglesia, Raquel Rodriguez-Gonzalez
Summary: The aim of this study was to investigate the impact of an augmented reality (AR)-based online educational experience on the academic performance and learning determinants of nursing students studying leg ulcer care. The study compared the outcomes of online learning with face-to-face learning. The results showed that AR-based online experience had a positive influence on academic performance and learning determinants.
NURSE EDUCATION IN PRACTICE
(2023)
Article
Neurosciences
Monica M. Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa J. Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola
Summary: This study reveals the critical role of meningeal T cells and macrophage IL-17 signaling in the neurovascular and cognitive dysfunction in a mouse model of hypertension.
NATURE NEUROSCIENCE
(2023)