Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Multidisciplinary Sciences
John P. Gleeson, Namit Chaudhary, Katherine C. Fein, Rose Doerfler, Patricia Hredzak-Showalter, Kathryn A. Whitehead
Summary: Breast milk contains cells that are beneficial for infant development, but little is known about these cells. This study characterized the cells in mature breast milk from healthy donors and identified the main cell population as epithelial cells, with several subpopulations including previously unidentified ones. These findings provide insights into the potential applications of breast milk cells in maternal and infant medicine.
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Cell & Tissue Engineering
Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper, Nathan R. Schiele
Summary: The study found that Akt signaling plays a role in TGF beta 2-induced tenogenesis, and that tenogenesis of MSCs can still be initiated by TGF beta 2 during inhibition of Smad3.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Environmental Sciences
Zeinab Rafiee, Mahmoud Orazizadeh, Fereshteh Nejad Dehbashi, Niloofar Neisi, Hossein Babaahmadi-Rezaei, Esrafil Mansouri
Summary: This study investigates the therapeutic potential of kidney stem cells (KSCs) in diabetic nephropathy (DN) and finds that KSCs significantly improve kidney function and structure in DN rats by regulating miRNA and cell signaling pathways.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell & Tissue Engineering
Matteo Mazzella, Keegan Walker, Christina Cormier, Michael Kapanowski, Albi Ishmakej, Azeem Saifee, Yashvardhan Govind, G. Rasul Chaudhry
Summary: This study investigated the self-renewal mechanism of primitive (p) MSCs and found that the Wnt pathway is associated with self-renewal potential, while senescence is linked to the TGF beta pathway. Transcriptomic and MNase-seq analysis revealed distinct gene expressions and nucleosome occupancies in pMSCs grown in xeno-free and fetal bovine serum medium, providing insights into the complex molecular mechanisms governing the self-renewal and senescence of MSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Milica Vukotic, Suncica Kapor, Teodora Dragojevic, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milos Diklic, Tijana Suboticki, Emilija Zivkovic, Bojana Beleslin Cokic, Aleksandar Vojvodic, Juan F. Santibanez, Mirjana Gotic, Vladan P. Cokic
Summary: Combining treatment options that target inflammatory pathways can improve fibrosis in patients with rare bone marrow disorders. Research has shown that an increase in inflammatory signaling pathways in patients with myeloproliferative neoplasms (MPN) leads to the differentiation of stem cells in the bone marrow into cells with dysregulated extracellular matrices, causing fibrosis. By combining two drugs that target these pathways, the development of fibrosis in MPN cell cultures can be inhibited.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Keiko Ishikawa, Shinya Sugimoto, Mayumi Oda, Masayuki Fujii, Sirirat Takahashi, Yuki Ohta, Ai Takano, Kazuhiro Ishimaru, Mami Matano, Kosuke Yoshida, Hikaru Hanyu, Kohta Toshimitsu, Kazuaki Sawada, Mariko Shimokawa, Megumu Saito, Kenta Kawasaki, Ryota Ishii, Koji Taniguchi, Takeshi Imamura, Takanori Kanai, Toshiro Sato
Summary: This study reveals the quiescent nature of human LGR5(+) colonic stem cells and their contribution to post-injury regeneration.
Article
Biochemical Research Methods
Kyungsoo Kim, Young Sik Kim, Ju Woong Jang, Gyun Min Lee
Summary: In this study, the production of recombinant human transforming growth factor-beta1 (rhTGF-beta 1) in Chinese hamster ovary (CHO) cells was enhanced through characterization and optimization. It was found that mature rhTGF-beta 1 was mostly produced in the form of latent rhTGF-beta 1 in CHO-rhTGF-beta 1 cells, and a significant amount of unprocessed precursors was also produced. Overexpression of PACEsol in CHO-rhTGF-beta 1 cells effectively cleaved the unprocessed precursors, resulting in increased production of mature rhTGF-beta 1.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Cell Biology
Ying-Wen Wang, Wen-Yu Lin, Fang-Ju Wu, Ching-Wei Luo
Summary: This study revealed, for the first time, the transcription landscape of all the genes that make up the TGF-beta superfamily signaling module in bone, providing novel hints for treating osteoporosis.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Clinical Neurology
Yifu Song, Yaochuan Zhang, Xiaoliang Wang, Xiaodi Han, Mengwu Shi, Ling Xu, Juanhan Yu, Li Zhang, Sheng Han
Summary: This study reveals that overexpression of SPI1 in glioma stem cells is positively correlated with the malignant MES phenotype and poor survival. SPI1 enhances the differentiation, self-renewal, and radioresistance of GSC MES in vitro, promoting tumorigenicity in vivo. Mechanistically, SPI1 activates the TGF-beta 1/ PI3K/ Akt signaling pathway through transcriptional upregulation of FKBP12. Inhibition of TGF-beta 1 / PI3K / Akt signaling partially attenuates SPI1-induced GSC MES differentiation and its associated malignant phenotype.
Article
Oncology
Pedro Garcia-Gomez, Irene Golan, Mahsa S. Dadras, Artur Mezheyeuski, Claudia Bellomo, Kalliopi Tzavlaki, Anita Moren, Jordi Carreras-Puigvert, Laia Caja
Summary: This study investigates the crucial roles of TGF beta and ROS in GSC biology, revealing the key regulatory function of NOX4 in GSCs.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Sol Han, Mi Kyung Kim, Byoung Kuk Jang
Summary: In this study, we found that evogliptin can inhibit inflammatory and fibrotic signaling in liver cells and induce autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto-Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza
Summary: The study found that TGF-beta 1 plays a significant role in the replication of dengue virus in macrophages, and targeting TGF-beta 1 may represent an alternative therapeutic strategy to be explored in dengue infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod
Summary: This article examines the complexity of the TGF-β pathway and its role in promoting oncogenic properties in TNBC, while also pointing out the significance of CSCs in breast cancer tumorigenesis, metastasis, relapse, resistance, and patient prognosis.
