Article
Environmental Sciences
Shih-Chang Chen, Chaou-Wen Lin, Po-Fu Lee, Hui-Ling Chen, Chien-Chang Ho
Summary: This study provides a reference for anthropometric data of Taiwanese adults, showing differences in measurements across different age groups, although with minor variations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Rui Gong, Jonathan Greenbaum, Xu Lin, Yan Du, Kuan-Jui Su, Yun Gong, Jie Shen, Hong-Wen Deng
Summary: Using a statistical fine-mapping approach, this study successfully identified potential causal variants with biological effects on obesity-related traits (BMI and WHR) and partially validated corresponding genes. These results provide novel insight into our understanding of the genetics of obesity and demonstrate that fine mapping can improve upon the results identified by the original GWASs.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Chunyan Hu, Rui Du, Lin Lin, Ruizhi Zheng, Hongyan Qi, Yuanyue Zhu, Ran Wei, Xueyan Wu, Yi Zhang, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yufang Bi, Guang Ning, Weiqing Wang, Yuhong Chen, Jieli Lu
Summary: The coexistence of early-life undernutrition and adulthood obesity increases the risk of dyslipidemia in later life. The association between famine exposure and dyslipidemia is more significant in women, and both general and central obesity have a significant impact on this association.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Koushik Bhattacharya, Pallav Sengupta, Sulagna Dutta, Prasenjit Chaudhuri, Lipika Das Mukhopadhyay, Alak Kumar Syamal
Summary: This study suggests that waist-to-height ratio (WHtR) can serve as a reliable screening tool for early prediction of PCOS and insulin resistance in PCOS women in Kolkata, India, with better performance than body mass index (BMI).
Article
Geriatrics & Gerontology
X. Liu, X. Chen, L. Hou, X. Xia, F. Hu, S. Luo, G. Zhang, B. Dong
Summary: This study found that higher middle age BMI is associated with cognitive decline, while higher WHR in the elderly is related to improved cognitive performance. WC is associated with cognitive decline in males, and WHR is closely connected to cognitive decline in participants with BMI<25kg/m(2).
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Endocrinology & Metabolism
Qiu-Xue Yi, Li-Na Zhu, Jing Ma, Xin-Jie Yu, Lin Liu, Jie Shen
Summary: In this study, waist-to-height ratio (WHtR) and body mass index (BMI) were identified as risk factors for diabetic retinopathy (DR) in obese patients with type 2 diabetes (T2D), while waist-to-hip ratio (WHR) showed no association with the occurrence of DR. Patients with high WHtR and BMI should be closely monitored to prevent the development of DR.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biology
Esra'a A. Aljazairy, Sara Al-Musharaf, Manal Abudawood, Basmah Almaarik, Syed D. Hussain, Abdullah M. Alnaami, Shaun Sabico, Nasser M. Al-Daghri, Mario Clerici, Ghadeer S. Aljuraiban
Summary: Obesity is a global health problem, but its prevalence has not decreased despite advances in therapeutic options. The gut microbiota is believed to play a role in obesity, but limited evidence exists, especially in the Middle-Eastern region. This study investigated the association between gut microbiota and obesity markers in Saudi women, revealing a potential link and providing insights for obesity management.
Article
Genetics & Heredity
Leila Najd-Hassan-Bonab, Niloufar Javanrouh Givi, Maryam Moazzam-Jazi, Sajedeh Masjoudi, Nasim Ghafari, Maryam S. Daneshpour
Summary: This study investigated the association between FABP2 gene polymorphisms and obesity in an Iranian population, and found that the rs10857064-G allele increased the risk of obesity in women. It highlights the importance of gender differences in obesity screening and treatment.
Article
Medicine, General & Internal
Maria Zadarko-Domaradzka, Marek Sobolewski, Emilian Zadarko
Summary: This study aimed to evaluate the value of six indicators in predicting cardiorespiratory fitness (CRF) in school-aged children. The results showed that relative fat mass was the strongest indicator, while waist-BMI ratio and waist-to-hip ratio were the weakest indicators. Relative fat mass can be used as a simple screening measure in prophylactic exams of school children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lauren E. E. Gyllenhammer, Allison M. M. Duensing, Madeline Rose Keleher, Katerina Kechris, Dana Dabelea, Kristen E. E. Boyle
Summary: This study used human infant umbilical cord-derived mesenchymal stem cells (MSCs) as a model system and found that the triglyceride content of these MSCs is associated with child adiposity and fasting glucose levels, predicting offspring metabolic phenotype.
Article
Psychiatry
Soundarya Soundararajan, Narjis Kazmi, Alyssa T. Brooks, Michael Krumlauf, Melanie L. Schwandt, David T. George, Colin A. Hodgkinson, Gwenyth R. Wallen, Vijay A. Ramchandani
Summary: This study investigates the impact of genetic variants in the endocannabinoid system on sleep quality in individuals with alcohol use disorder, finding a dose-dependent relationship between alcohol consumption and sleep quality, as well as significant associations between genetic variations and sleep quality. Genotypes also influence objective sleep measures, indicating a significant role of the endocannabinoid system in alcohol-related sleep phenotypes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Felix Teufel, Jacqueline A. Seiglie, Pascal Geldsetzer, Michaela Theilmann, Maja E. Marcus, Cara Ebert, William Andres Lopez Arboleda, Kokou Agoudavi, Glennis Andall-Brereton, Krishna K. Aryal, Brice Wilfried Bicaba, Garry Brian, Pascal Bovet, Maria Dorobantu, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Dismand Houinato, Jutta M. Adelin Jorgensen, Gibson B. Kagaruki, Khem B. Karki, Demetre Labadarios, Joao S. Martins, Mary T. Mayige, Roy Wong McClure, Joseph Kibachio Mwangi, Omar Mwalim, Bolormaa Norov, Sarah Crooks, Farshad Farzadfar, Sahar Saeedi Moghaddam, Bahendeka K. Silver, Lela Sturua, Chea Stanford Wesseh, Andrew C. Stokes, Utibe R. Essien, Jan-Walter De Neve, Rifat Atun, Justine I. Davies, Sebastian Vollmer, Till W. Barnighausen, Mohammed K. Ali, James B. Meigs, Deborah J. Wexler, Jennifer Manne-Goehler
Summary: The prevalence of overweight, obesity, and diabetes is increasing rapidly in low-income and middle-income countries, with BMI affecting the risk of diabetes, but there are significant regional variations in this association.
Article
Peripheral Vascular Disease
Rahel Dereje, Kalkidan Hassen, Getu Gizaw
Summary: The study found waist-to-height ratio to be the best index for screening hypertension, supporting its use in resource-limited settings for screening hypertension.
INTEGRATED BLOOD PRESSURE CONTROL
(2021)
Article
Endocrinology & Metabolism
Sheryl L. Rifas-Shiman, Izzuddin M. Aris, Charles Bailey, Matthew F. Daley, William J. Heerman, David M. Janicke, Pi-I Debby Lin, Joshua Petimar, Jason P. Block
Summary: This study examined the impact of the COVID-19 pandemic on obesity and BMI among children and adolescents with chronic conditions. The results showed an increase in obesity prevalence and BMI z score during the pandemic, particularly among children aged 5 to 13 years and 13 to 18 years. The study also found that male, Black, Hispanic, and children prescribed antihypertensives experienced the highest increases in obesity prevalence.
Article
Oncology
Lindsay Joyce Nitsche, Sarbajit Mukherjee, Kareena Cheruvu, Cathleen Krabak, Rohit Rachala, Kalyan Ratnakaram, Priyanka Sharma, Maddy Singh, Sai Yendamuri
Summary: Many studies have indicated a link between obesity and negative health effects, including worse outcomes for cancer patients. However, some studies paradoxically suggest that obesity may actually have a survival benefit in certain types of cancer treatment. This relationship may be due to inadequate quantification of adiposity, enhanced immune response, and factors such as sex, medication use, and smoking. Accurate measurement of abdominal obesity is likely crucial in predicting prognosis. Understanding the factors contributing to the obesity paradox and its impact on lung cancer can aid in the treatment and prognosis of this disease and may lead to further research on the specific effects of obesity on cancer.
Article
Neurosciences
Bruno Lopes Santos-Lobato, Artur F. Schumacher-Schuh, Carlos R. M. Rieder, Mara H. Hutz, Vanderci Borges, Henrique Ballalai Ferraz, Ignacio F. Mata, Cyrus P. Zabetian, Vitor Tumas
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Article
Psychiatry
Thais Martins-Silva, Juliana dos Santos Vaz, Julia Pasqualini Genro, Mara Helena Hutz, Christian Loret de Mola, Nina Roth Mota, Isabel Oliveira, Denise Petrucci Gigante, Ricardo Tavares Pinheiro, Eduardo Vitola, Eugenio Grevet, Bernardo L. Horta, Luis Augusto Rohde, Luciana Tovo-Rodrigues
Summary: The study found an association between obesity and ADHD, with BMI and FM being related to ADHD. The BMI polygenic risk score was associated with ADHD, and genes related to the reward system may play a role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nathalia Louize Nunes Vieira Silva, Alvaro Della Bona, Moises Cardoso, Sidia Maria Callegari-Jacques, Fernando Fornari
Summary: The probiotic Lactobacillus brevis CD2 was found to reduce the duration of traumatic oral lesions and alleviate pain caused by fixed orthodontic appliances, though it did not significantly improve oral health-related quality of life in comparison to a placebo.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cleonardo Augusto Silva, Arthur Ribeiro-dos-Santos, Wanderson Goncalves Goncalves, Pablo Pinto, Rafael Pompeu Pantoja, Tatiana Vinasco-Sandoval, Andre Mauricio Ribeiro-dos-Santos, Mara Helena Hutz, Amanda Ferreira Vidal, Gilderlanio Santana Araujo, Andrea Ribeiro-dos-Santos, Sidney Santos
Summary: This study utilized Next Generation Sequencing techniques to evaluate global miRNA expression profiles in patients with tuberculosis, healthy physicians, and healthy controls. The results identified potential miRNA biomarkers and observed modified immune response pathways due to differential miRNA expression profiles. The findings suggest a role for miRNAs in immune modulation by regulating gene expression in immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Marina Xavier Carpena, Carolina Bonilla, Alicia Matijasevich, Thais Martins-Silva, Julia P. Genro, Mara Helena Hutz, Luis Augusto Rohde, Luciana Tovo-Rodrigues
Summary: The study found a positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD. Insomnia, daytime sleepiness, and snoring shared genes with ADHD involved in neurobiological functions and regulatory signalling pathways. Mendelian randomisation supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Sport Sciences
Caroline Brand, Ana Paula Sehn, Pamela Ferreira Todendi, Andreia Rosane de Moura Valim, Vanessa Sune Mattevi, Antonio Garcia-Hermoso, Anelise Reis Gaya, Cezane Priscila Reuter
Summary: The study indicates that sleep duration and screen time have a significant effect on the relationship between genetic predisposition for obesity and waist circumference in children and adolescents, while physical activity does not show significant interaction. Therefore, adequate sleep and reduced screen time may help mitigate the risk of obesity in children and adolescents.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Plant Sciences
Marcelo C. Teixeira, Caroline Turchetto, Carolina K. Schnitzler, Sidia M. Callegari-Jacques, Loreta B. Freitas
Summary: The study showed differences in self-compatibility degree among individuals, lineages, and pollination treatments, with high total seed production and germination. High self-compatibility and inter-lineage compatibility contribute to the maintenance and origin of hybrid populations, facilitating introgression of the two analyzed species.
ACTA BOTANICA BRASILICA
(2021)
Article
Psychiatry
Thailan Teles Fraporti, Cibele Edom Bandeira, Luciana Tovo-Rodrigues, Thais Martins-Silva, Mara Helena Hutz, Luis Augusto Rohde, Claiton Henrique Dotto Bau, Eugenio Horacio Grevet, Bruna Santos da Silva, Diego Luiz Rovaris, Fabiane Dresch, Veronica Contini, Julia Pasqualini Genro
Summary: The study found an association between a gene-set related to caffeine response and anxiety disorders in children with ADHD, as well as in adults with the number of anxiety disorders. However, there was no significant association between the gene-set and ADHD or anxiety disorders in the control sample. Additionally, no significant results were observed in the analysis with ADHD and AD GWAS summary statistics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bruna Kulmann-Leal, Joel Henrique Ellwanger, Jacqueline Maria Valverde-Villegas, Daniel Simon, Camila Guerra Marangon, Vanessa Sune Mattevi, Rosmeri Kuhmmer Lazzaretti, Regina Kuhmmer, Eduardo Sprinz, Jose Artur Bogo Chies
Summary: This study suggests that the 2848 G/A variant of the TLR9 gene may have a potential influence on host susceptibility to viral infections in Brazilians. However, this influence is no longer significant if adjustment by multiple comparisons is considered.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Genetics & Heredity
Bruno Toson, Rafael T. Michita, Maria C. T. Matte, Robson Soares, Gabriela K. S. Lawisch, Vanessa S. Mattevi, Jose A. B. Chies
Summary: This study evaluated the impact of NKG2C deletion on HIV susceptibility in a Brazilian population. The results showed no association between NKG2C deletion and HIV-1 susceptibility, HBV or HCV co-infection, or clinical features. This suggests that other signaling pathways may compensate for the absence of NKG2C receptor expression to prevent deleterious phenotypes.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Endocrinology & Metabolism
Laura Berton Eidt, Caren Nunes de Oliveira, Yago Borges Biz De Lagos, Geise Lilian Menezes Solera, Rogerio Izquierdo, Erika Laurini de Souza Meyer, Vanessa Sune Mattevi, Lenara Golbert
Summary: This study compares the accuracy of the ACR-TIRADS and EU-TIRADS ultrasound classification systems for thyroid nodules. The results show that both systems have high sensitivity but low specificity in selecting nodules for FNA-US, and there is controversy regarding the use of nodule size for FNA-US selection.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Maria Eduarda Krutzmann, Ranieri Reichel Martini, Fernanda de Souza Guterres, Ramona Kohlrausch, Sandrine Comparsi Wagner, Vanessa Sune Mattevi, Mayde Seadi Torriani, Laura Maria Fogliatto, Rafael Linden, Marina Venzon Antunes
Summary: Chronic myeloid leukemia is a hematologic neoplasia and Imatinib mesylate is recommended as a first-line therapy. Therapeutic drug monitoring is crucial for treatment response evaluation and adherence assessment. Volumetric absorptive microsampling is a convenient device for home blood collection. The study demonstrates that VAMS can be used for therapeutic drug monitoring in patients with chronic myeloid leukemia.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Janaina Kehl de Castilhos, Paula Dal Bo Campagnolo, Silvana de Almeida, Marcia Regina Vitolo, Vanessa Sune Mattevi
Summary: This study examined the impact of a dietary intervention in the first year of life on global DNA methylation levels in leukocyte samples of children born in southern Brazil between 2001 and 2002. Results showed that nutritional counseling in the first year increased global DNA methylation and promoted the development of healthier eating habits, indicating the importance of early nutritional interventions and the interaction between environmental factors and epigenetic traits.
GENETICS AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mirelen Moura de Oliveira Rodrigues, Gabriela Hoher, Gabriela Waskow, Mara Helena Hutz, Juliana Dal-Ri Lindenau, Maria Luiza Petzl-Erler, Sidia Maria Callegari-Jacques, Silvana Almeida, Marilu Fiegenbaum
Summary: The study reveals significant differences in blood group marker frequencies, particularly Diego, Kidd, and Duffy variants, in Native American populations compared to individuals from different regions of Brazil, indicating ongoing admixture. The findings emphasize the importance of better ethnic characterization of blood unit receptors, as the frequency of red blood cell polymorphisms in Native American groups differs substantially from that of blood donors when considering blood groups other than ABO and Rh systems.
GENETICS AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmela Farias da Silva Tagliari, Caren Nunes de Oliveira, Greice Meyer Vogel, Patricia Baptista da Silva, Rafael Linden, Rosmeri Kuhmmer Lazzaretti, Regina Kuhmmer Notti, Eduardo Sprinz, Vanessa Sune Mattevi
GENETICS AND MOLECULAR BIOLOGY
(2020)
