Article
Medicine, General & Internal
Shu hui Peng, Hussein Said Mbarak, Yan-Hui Li, Cong Ma, Quan-Liang Shang, Zhu Chen, Du-Jun Bian, En-Hua Xiao
Summary: Preoperative transcatheter arterial infusion chemotherapy is a safe and effective neoadjuvant chemotherapy measure for CRC, with fewer adverse reactions and a higher overall disease control rate compared to intravenous chemotherapy.
Review
Oncology
Justin Kwan, Uei Pua
Summary: Liver is the most common site of metastasis in colorectal cancer patients, with surgery being the only potential curative option for a small percentage of patients. Advances in modern chemotherapy and personalized biological agents have improved overall survival in patients with unresectable liver metastasis. Liver-directed intra-arterial therapies are increasingly being considered to improve local tumor response and reduce systemic side effects in patients with dominant liver metastatic disease or limited extrahepatic disease.
Article
Surgery
Dexiang Zhu, Jianguo Xia, Yan Gu, Jianjiang Lin, Kefeng Ding, Bo Zhou, Fei Liang, Tianshu Liu, Chunzhi Qin, Ye Wei, Li Ren, Yunshi Zhong, Jianhua Wang, Zhiping Yan, Jiemin Cheng, Jingwen Chen, Wenju Chang, Shaokang Zhan, Yongbin Ding, Haizhong Huo, Fanlong Liu, Junhui Sun, Xinyu Qin, Jianmin Xu
Summary: The study demonstrated that the addition of preoperative hepatic and regional arterial chemotherapy (PHRAC) could improve disease-free survival (DFS), reduce the incidence of liver metastasis (LM), and enhance overall survival (OS) in patients with stage II and III colorectal cancer (CRC). Furthermore, it did not increase treatment-related morbidity or mortality, indicating that PHRAC is a safe and effective treatment option for these patients.
Review
Oncology
Yan Zhang, Kaili Wang, Tao Yang, Yibo Cao, Wanling Liang, Xiangdong Yang, Tianbao Xiao
Summary: The meta-analysis in this study suggests that hepatic arterial infusion chemotherapy (HAIC) may be a potential therapeutic regimen that could improve the outcomes of patients with colorectal liver metastases.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hongyi Dammu, Thomas Ren, Tim Q. Duong
Summary: The goal of this study was to use a novel deep-learning convolutional-neural-network (CNN) to predict pathological complete response (PCR), residual cancer burden (RCB), and progression-free survival (PFS) in breast cancer patients treated with neoadjuvant chemotherapy using longitudinal multiparametric MRI, demographics, and molecular subtypes as inputs. The results showed that the Integrated approach of CNN outperformed the Stack or Concatenation CNN, and the combination of MRI and non-MRI data performed better than either alone. The best model achieved an accuracy of 0.81 for PCR prediction, 0.80 for RCB prediction, and a mean absolute error of 24.6 months for PFS prediction.
Article
Multidisciplinary Sciences
Gulcan Bulut, Merve Guner Oytun, Elvina Almuradova, Mustafa Harman, Ruchan Uslu, Bulent Karabulut
Summary: This study revealed that achieving complete response in patients with unresectable metastatic colorectal cancer has a positive impact on both overall survival and progression-free survival. Patients who attained complete response generally had better prognosis, especially in those who underwent primary tumor resection.
Review
Gastroenterology & Hepatology
Florian E. Buisman, Wills F. Filipe, Boris Galjart, Dirk J. Grunhagen, Marjolein Y. V. Homs, Adriaan Moelker, Cornelis Verhoef, Bas Groot Koerkamp
Summary: This meta-analysis demonstrates that adjuvant hepatic arterial infusion chemotherapy (HAIC) is a promising treatment for patients with resectable colorectal liver metastasis (CRLM), particularly when using floxuridine, a surgically placed catheter with a subcutaneous pump, and concomitant systemic chemotherapy.
Article
Medicine, Research & Experimental
Nikki S. IJzerman, Wills F. Filipe, Peter de Bruijn, Florian E. Buisman, Leni van Doorn, Pascal G. Doornebosch, Jessica J. Holster, Cecile Grootscholten, Dirk J. Gruenhagen, Christian P. E. van Bommel, Marjolein Y. V. Homs, Niels F. M. Kok, Cornelis Verhoef, Bas Groot Koerkamp, Koert F. D. Kuhlmann, Ron H. J. Mathijssen, Stijn L. W. Koolen
Summary: This study aimed to quantify the systemic exposure of floxuridine and found that most patients had low concentrations of floxuridine, which decreased over time, indicating minimal systemic side-effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Laleh G. Melstrom, Susanne G. Warner, Paul Wong, Virginia Sun, Mustafa Raoof, Gagandeep Singh, Kenneth D. Chavin, Yuman Fong, Rene Adam, Thomas J. Hugh
Summary: The majority of hepatobiliary surgeons tend to observe rather than intervene in the management of disappearing colorectal liver metastases (dCRLM) due to the belief that these lesions may be re-addressed in the future.
Article
Surgery
Nancy E. Kemeny, Joanne F. Chou, Marinela Capanu, Walid K. Chatila, Hongyu Shi, Francisco Sanchez-Vega, Thomas Peter Kingham, Louise Catherine Connell, William R. Jarnagin, Michael I. D'Angelica
Summary: The study aimed to determine whether adding Pmab to the adjuvant regimen of HAI FUDR + SYS FOLFIRI for RAS wild-type colorectal cancer patients improves 15-month recurrence-free survival, and found that the activity in the Pmab arm was significantly better than the arm without Pmab. In addition, toxicity was similar between the two arms, with the Pmab arm not showing a significant increase in biliary toxicity.
Article
Surgery
Liam H. Wong, Thomas L. Sutton, Brett S. Walker, Charles D. Lopez, Adel Kardosh, Robert L. Eil, Emerson Y. Chen, Kevin G. Billingsley, Skye C. Mayo
Summary: Repeat hepatectomy for recurrent colorectal liver metastases can be performed safely, with additional post-operative chemotherapy associated with improved outcomes. Poor survival following repeat hepatectomy is independently associated with certain factors including tumor size and time to recurrence.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Ji Su Kim, Hyunwook Kim, Seo Young Lee, Yoon Dae Han, Kichang Han, Byung Soh Min, Man-Deuk Kim, Jong Yun Won, Seung-Hoon Beom, Sang Joon Shin, Han Sang Kim, Dai Hoon Han, Joong Bae Ahn
Summary: This study aims to evaluate the efficacy of HAI oxaliplatin in combination with sys-CT plus targeted therapy in patients with unresectable CRC with liver-only metastasis, with the goal of increasing the rate of conversion to liver resection.
Article
Gastroenterology & Hepatology
Mudassar A. Ghazanfar, Amir Abdelhamid, Luca Aldrighetti, Christian Sturesson, Nobuyuki Takemura, Stephanie Truant, Guido Fiorentini, Catherine Teh, Ruslan Alikhanov, Irfan Ahmed, John Hammond, Alessandro Ferrero, Michael Silva, Timothy Pawlik, Robert Jones, Mohamed Bekheit
Summary: This survey aimed to evaluate the consistency in the management of disappeared colorectal liver metastases (dCRLM) among liver surgeons in different countries. Colorectal liver metastases (CRLM) account for half of the deaths secondary to colorectal cancer, and the management of dCRLMs remains unclear due to the high utilization of chemotherapy before surgery.
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Frederic Dumont, Cecile Loaec, Romuald Wernert, Blandine Maurel, Emilie Thibaudeau, Laurence Vilcot
Summary: This study aimed to identify prognostic factors and determine the optimal extent of surgery for local recurrence following colorectal cancer. The results showed that complete compartmental surgery is safe and improves local control.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Zhenggang Ren, Michel Ducreux, Ghassan K. Abou-Alfa, Philippe Merle, Weijia Fang, Julien Edeline, Zhiwei Li, Lihua Wu, Eric Assenat, Sheng Hu, Lorenza Rimassa, Tao Zhang, Jean-Frederic Blanc, Hongming Pan, Paul Ross, Chia-Jui Yen, Albert Tran, Guoliang Shao, Mohamed Bouattour, Yajin Chen, Tim Meyer, Jinlin Hou, David Tougeron, Yuxian Bai, Ming-Mo Hou, Zhiqiang Meng, John Wu, Vincent Li, Sandra Chica-Duque, Ann-Lii Cheng
Summary: Tislelizumab demonstrated durable antitumor activity and acceptable tolerability in previously treated advanced HCC patients, regardless of the number of prior lines of therapy.
Article
Oncology
Chiun Hsu, Michel Ducreux, Andrew X. Zhu, Shukui Qin, Masafumi Ikeda, Tae-You Kim, Peter R. Galle, Richard S. Finn, Ethan Chen, Ning Ma, Youyou Hu, Lindong Li, Ann-Lii Cheng
Summary: The IMbrave150 trial showed that atezolizumab + bevacizumab is safe and effective in treating patients with hepatocellular carcinoma, including those with hepatitis B or hepatitis C infection.
Article
Oncology
Masatoshi Kudo, Richard S. S. Finn, Peter R. R. Galle, Andrew X. X. Zhu, Michel Ducreux, Ann-Lii Cheng, Masafumi Ikeda, Kaoru Tsuchiya, Ken-ichi Aoki, Jing Jia, Riccardo Lencioni
Summary: The study demonstrates the efficacy and safety of atezolizumab + bevacizumab treatment in patients with baseline BCLC Stage B hepatocellular carcinoma, consistent with the overall study population.
Article
Oncology
Frederic Dumont, Vahan Kepenekian, Valeria De Franco, Clarisse Eveno, Patrick Rat, Charles Sabbagh, Jean-Jacques Tuech, Jean-Marc Bereder, Maxime Gerard, Cecile Loaec, Elodie Martin, Loic Campion, Olivier Glehen
Summary: Multimodal treatment, including perioperative chemotherapy and complete resection, improves survival in patients with peritoneal metastases from colorectal cancer. However, the impact of treatment delays on oncologic outcomes remains uncertain.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Youssef Mahdi, Mouna Khmou, Amine Souadka, Hajar El Agouri, Soumaya Ech-charif, Chaimaa Mounjid, Basma El Khannoussi
Summary: This study reports the largest analysis of NRAS and KRAS status in colorectal metastatic patients in North Africa. The study found that KRAS mutations occurred in approximately 51.7% of tumors, mainly in exon 12, while NRAS mutations were found in only 3% of tumors. The study also found a significant correlation between NRAS mutations and age.
BMC GASTROENTEROLOGY
(2023)
Letter
Oncology
Amine Souadka, Brahim El Ahmadi
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Review
Oncology
Raefa Abou Khouzam, Jean-Marie Lehn, Hemma Mayr, Pierre-Alain Clavien, Michael Bradley Wallace, Michel Ducreux, Perparim Limani, Salem Chouaib
Summary: Hypoxia is a crucial characteristic of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and plays a significant role in its pathogenesis. This review focuses on the impact of hypoxia on genomic instability and the tumor immune microenvironment in PDAC. Strategies for alleviating hypoxia and their potential applications for diagnosis and therapy in PDAC patients will also be discussed.
Letter
Oncology
Mohammed Oussama Louafi, Oumayma Lahnaoui, Amine Benkabbou, Mohammed Anass Majbar, Raouf Mohsine, Basma El Khannoussi, Saber Boutayeb, Amine Souadka
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Oumayma Lahnaoui, Hajar Essangri, Nezha El Bahaoui, Mohammed Anass Majbar, Amine Benkabbou, Raouf Mohsine, Amine Souadka
Summary: In ULRC patients, PCPC is a cost-effective alternative to the standard definitive colostomy without alteration of the QOL or additional perineal complications during the first 6 months following the surgery.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Paul Matte, Michel Ducreux
Summary: This article reports a case of a patient with low rectal cancer who experienced vision loss 3 weeks after starting treatment with capecitabine and radiotherapy. After ruling out other possible diagnoses, toxicity of the antineoplastic agent is considered the most likely hypothesis, making it the first case of vision loss induced by capecitabine.
CASE REPORTS IN ONCOLOGY
(2023)
Article
Surgery
Hamza Sekkat, Amine Souadka, Leila Alaoui, Ali Rafik, Zakaria Belkhadir, Laila Amrani, Amine Benkabbou, Raouf Mohsine, Anass Mohammed Majbar
Summary: This study aimed to analyze the learning curve of two millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery program in a low- and middle-income country cancer center. The study found that both surgeons had a safe and short learning curve in terms of operative duration and conversion to open surgery.
JOURNAL OF MINIMAL ACCESS SURGERY
(2023)
Letter
Oncology
Amine Souadka, Saber Boutayeb, Basma El Khannoussi, Hanane El Kacimi, Oumayma Lahnaoui, Amine Benkabbou, Mohammed Anass Majbar, Abdelilah Ghannam, Zakaria Houssain Belkhadir, Raouf Mohsine, Brahim El Ahmadi
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Surgery
Hajar Essangri, Nezha El Bahaoui, Abdelilah Souadka, Mohammed Anass Majbar, Amine Benkabbou, Raouf Mohsine, Amine Souadka
BRITISH JOURNAL OF SURGERY
(2022)