Article
Infectious Diseases
Edyta Golinska, L. Kozien, A. Tomusiak-Plebanek, J. Kedzierska, M. Dorycka, R. Lauterbach, D. Pawlik, B. Rzepecka-Weglarz, M. Janiszewska, Pb Heczko, J. Wojkowska-Mach, M. Strus
Summary: This study compared demographic and clinical features of main pathogens related to neonatal sepsis in two neonatal intensive care units over a 24-month period. Results showed a predominance of CoNS resistant to methicillin in late-onset bloodstream infections and beta-lactam resistant E. coli in early-onset bloodstream infections. The campaign for controlling GBS carriage in pregnant women in Poland led to the disappearance of GBS as a cause of sepsis, but measures to control E.coli related sepsis are lacking.
BMC INFECTIOUS DISEASES
(2023)
Article
Microbiology
Vanessa Silva, Elisete Correia, Jose Eduardo Pereira, Camino Gonzalez-Machado, Rosa Capita, Carlos Alonso-Calleja, Gilberto Igrejas, Patricia Poeta
Summary: This study evaluates the ability of biofilm formation in coagulase-negative staphylococci (CoNS) and S. pseudintermedius isolated from various animal species, and investigates the effect of conventional antimicrobials on reducing biofilm. The results show that all isolates can form biofilm, with S. urealyticus producing the most biomass and S. pseudintermedius producing the least biomass. Biofilm formation is positively associated with multidrug resistance and resistance to individual antimicrobials. Tetracycline and amikacin were unable to eradicate the biofilm, even at high concentrations.
Article
Infectious Diseases
Svetlana Kolesnichenko, Irina A. Kadyrova, Alyona Lavrinenko, Zhibek A. Zhumadilova, Olga Avdienko, Yelena V. Vinogradskaya, Yevgeniy A. Fominykh, Lyudmila G. Panibratec, Lyudmila L. Akhmaltdinova
Summary: A cohort study conducted in Kazakhstan during the COVID-19 pandemic found that low birth weight, gestational age, and comorbidities were associated with negative outcomes in infants with neonatal sepsis. Additionally, more than half of the newborns tested positive for anti-SARS-CoV-2 antibodies.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Applied
Li Yang, Hongjun Li, Han Wu, Shuyun Liu, Chang Su, Zhifei He
Summary: This study isolated and identified Coagulase-negative Staphylococci (CNS) from Chinese bacon, and evaluated their ability to degrade proteins and improve the taste of the bacon. Two CNS species were found to be capable of degrading proteins and enhancing the taste of Chinese bacon.
Review
Microbiology
Angela Franca, Vania Gaio, Nathalie Lopes, Luis D. R. Melo
Summary: Coagulase-negative staphylococci (CoNS) have become major pathogens in healthcare-associated facilities, with a focus on biofilm formation and antibiotic resistance genes. These factors make treatment challenging, despite their lower virulence compared to S. aureus.
Article
Microbiology
Luiza Pinheiro-Hubinger, Danilo Flavio Moraes Riboli, Ligia Maria Abraao, Eliane Patricia Lino Pereira Franchi, Maria de Lourdes Ribeiro de Souza da Cunha
Summary: This study compared the clonality and SCCmec type of CoNS isolates from different sources in the same community, revealing high clonal diversity in S. epidermidis and circulation of some S. haemolyticus clones in both hospital and community. The presence of different SCCmec types within the same cluster indicated high diversity, suggesting SCCmec may not be a good marker of clonality in these bacteria.
Article
Food Science & Technology
Wioleta Chajecka-Wierzchowska, Joanna Gajewska, Anna Zadernowska, Cinzia Lucia Randazzo, Cinzia Caggia
Summary: The present study aimed to evaluate and describe the diversity of CoNS strains as potential vectors for the transmission of antimicrobial resistance from RTE foods served in bars and restaurants. The study found that out of 85 CoNS strains, 67 strains were resistant to at least one antibiotic, with 37 strains exhibiting multidrug resistance (MDR-CoNS). Furthermore, CoNS strains carried resistance genes for antibiotics critically important in medicine, such as beta-lactams, aminoglycosides, and tetracyclines. The high frequency of MDR-CoNS in RTE foods poses a direct risk to public health as it contributes to the gene pool for acquisition of resistance traits by pathogenic bacteria.
Article
Microbiology
Vladimir Gostev, Semen Leyn, Alexander Kruglov, Daria Likholetova, Olga Kalinogorskaya, Marina Baykina, Natalia Dmitrieva, Zlata Grigorievskaya, Tatiana Priputnevich, Lyudmila Lyubasovskaya, Alexey Gordeev, Sergey Sidorenko
Summary: Coagulase-negative staphylococci (CoNS) were historically considered non-pathogenic, but strains such as S. epidermidis, S. haemolyticus, and S. hominis have now been identified as opportunistic pathogens. The off-label use of linezolid for CoNS infections has led to the emergence of international linezolid-resistant lineages. Genetic analysis revealed the presence of common ancestors for linezolid-resistant strains in different countries.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Yu Jin Lee, Young Ju Lee
Summary: This study investigated the pathogenic potential of Coagulase-negative staphylococci (CoNS) isolated from bulk tank milk. The results showed that these bacteria exhibited a high prevalence of biofilm-forming ability and multidrug resistance. Therefore, developing a strong monitoring and sanitation program for dairy factories is crucial for ensuring hygienic milk production.
VETERINARY SCIENCES
(2022)
Article
Microbiology
Matthijs S. Berends, Christian F. Luz, Alewijn Ott, Gunnar Andriesse, Karsten Becker, Corinna Glasner, Alex W. Friedrich
Summary: This retrospective study provides an in-depth data analysis of CoNS isolates found in human blood culture isolates in the Northern Netherlands between 2013 and 2019. The study identifies 27 different CoNS species and observes significant differences in occurrence and antibiotic resistance profiles. However, these differences are often neglected in national guidelines.
Review
Microbiology
Ricarda Michels, Katharina Last, Soeren L. Becker, Cihan Papan
Summary: Coagulase-negative staphylococci (CoNS) are common pathogens in clinical care, particularly affecting preterm neonates and patients with implanted medical devices. Challenges in correctly identifying CoNS infections remain a major diagnostic hurdle.
Article
Agriculture, Dairy & Animal Science
Agnieszka Marek, Ewelina Pyzik, Dagmara Stepien-Pysniak, Marta Dec, Lukasz S. Jarosz, Anna Nowaczek, Magdalena Sulikowska
Summary: Staphylococcus bacteria are commonly found on warm-blooded animals, with some species causing opportunistic infections in poultry. This study aimed to analyze the biofilm-forming potential and occurrence of biofilm-associated genes in coagulase-negative Staphylococcus strains isolated from poultry. The majority of strains showed biofilm production capacity, with varying levels of strength demonstrated. Some key biofilm-associated genes were detected in a subset of strains.
Article
Infectious Diseases
Yahya Mohzari, Fahad Aljobair, Ahmed Alrashed, Syed Mohammed Basheeruddin Asdaq, Renad Abdullah Alshuraim, Suzan Suhail Asfour, Mountasser Mohammad Al-Mouqdad, Reem F. Bamogaddam, Deemah Al-Anazi, Catherine E. Zeilinger, Ahmad Alamer, Batool Mohammed Alhassan, Nagaraja Sreeharsha
Summary: In recent years, there has been an increase in the prevalence of gram-positive bacteremia in neonates, but better care has also led to improved survival rates for premature neonates. Coagulase-negative staphylococci (CoNS) is the most common pathogen, and daptomycin has shown to be effective in treating it. The study demonstrates that daptomycin has a higher clinical cure rate in neonates with gram-positive infections.
Article
Agriculture, Dairy & Animal Science
M. Klempt, C. M. A. P. Franz, P. Hammer
Summary: This study highlights the potential presence of harmful bacteria in cheese, carrying antibiotic resistance genes and posing food safety concerns that warrant further evaluation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Shmuel Benenson, Matan J. Cohen, Nofar Greenglick, Carmela Schwartz, Smadar Eventov-Friedman, Zivanit Ergaz
Summary: This study aimed to assess the value of specific clinical information and CoNS cultures in diagnosing true bacteremia in neonatal intensive care units (NICUs). The results showed that despite difficulties in obtaining blood cultures in neonates, diagnosis should be based on at least two positive blood cultures.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)