Article
Oncology
Joshua Hamilton, Anne Breggia, Timothy L. Fitzgerald, Michael A. Jones, Peter C. Brooks, Karissa Tilbury, Andre Khalil
Summary: This study aimed to explore the application of second harmonic generation and 2D wavelet transform modulus maxima anisotropy method in quantifying collagen organization in PDAC. The results showed that cancer and fibrotic tissue had higher anisotropy factors at small wavelet scales, while normal tissue had higher anisotropy factors at larger scales.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Karissa Tilbury, XiangHua Han, Peter Brooks, Andre Khalil
Summary: The study introduced a modified 2D wavelet transform modulus maxima anisotropy method to detect collagen fiber organization in different types of skin, revealing significant differences at multiple scales.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Gastroenterology & Hepatology
Naohiro Yoshida, Hisashi Doyama, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Yoshinobu Yamamoto, Naomi Kakushima, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Ichiro Oda, Chikatoshi Katada, Chizu Yokoi, Ken Ohata, Kenichi Yoshimura, Hideki Ishikawa, Manabu Muto
Summary: This study conducted an open-label, randomized controlled trial in high-risk gastric cancer patients, finding that 2G-NBI did not increase the detection rate of early gastric cancer. Although there were differences in the positive predictive value of suspicious lesions between the WLI group and 2G-NBI group, overall sensitivity still needs improvement.
Article
Optics
Chenglin Wang, Andrey Novitsky, Wenxuan Ge, Dongliang Gao, Lei Gao
Summary: In this paper, high second-harmonic generation (SHG) conversion efficiency is achieved by combining the strong second-order nonlinear effects of graphene and the field-enhancing effects of anisotropic materials. The nonlinear conversion efficiency of radial anisotropic nanoparticles is found to be several orders of magnitude higher than that of isotropic counterpart, due to the additional enhancement of field intensity near the boundary provided by radial anisotropic and the presence of graphene at the particle boundary where the fundamental frequency field is significantly enhanced. Moreover, the highly tunable characteristic of graphene offers additional flexibility for manipulating the SHG spectrum in practical applications.
Article
Chemistry, Multidisciplinary
Chenshuang Zhang, Fangrui Lin, Yong Zhang, Haozhi Yang, Danying Lin, Jun He, Changrui Liao, Xiaoyu Weng, Liwei Liu, Yiping Wang, Bin Yu, Junle Qu
Summary: MSIM-SHG is a novel approach that combines second-harmonic generation (SHG) with multifocal structured illumination microscopy (MSIM) to achieve super-resolution imaging. It has wide applications in imaging material molecules and quantifying collagen fiber alignment, showing potential for clinical diagnosis and biological research.
Article
Nanoscience & Nanotechnology
Aswin Alexander, Mayank Gupta, Dileep Kottilil, Bibhuti Bhusan Rath, Jagadese J. Vittal, Wei Ji
Summary: Metal complexes have been gaining attention in recent times over traditional inorganic materials, showing advantages such as two-photon absorption and second harmonic generation. By controlling the incident light polarization, tunability between these two nonlinear optical processes can be achieved. The observed SHG d(eff) values of one complex are determined to be one order of magnitude greater than beta-BBO crystals.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Wei Li, Yunpeng Ma, Tianyi Feng, Ziwan Du, Yixuan Liu, Sergei Kalinin, Jing-Feng Li, Qian Li
Summary: Understanding symmetry breaking in ferroelectric materials is crucial for manipulating their functional properties. We developed a spectral imaging method using optical second harmonic generation to investigate the mechanisms behind crystallographic symmetry breaking. By studying (K,Na)NbO3 single crystals, we demonstrated the method's ability to analyze domain variants and their thermal evolution across phase transitions. The method can be extended to other ferroelectric materials with potential enhancements.
JOURNAL OF MATERIOMICS
(2023)
Article
Chemistry, Multidisciplinary
Bin Dong, Junjun Liu, Man Xue, Ziyue Ni, Yuan Guo, Zhifeng Huang, Zhen Zhang
Summary: The combination of SHG and linear dichroism, or SHG-LD, is used to study the chiroptical origin of silver chiral nanoparticles deposited by glancing angle deposition. The study reveals that the chiroptical activity of the silver CNPs is attributed to both structural chirality and one-fold anisotropy at the interface caused by substrate rotation during GLAD. This technique has great potential to provide valuable complementary information for studying the chiroptical properties of chiral metamaterials.
Article
Chemistry, Multidisciplinary
Biwei Wu, Keyi Wu, Xuefeng Sun, Weibo Wang, Jiubin Tan
Summary: This paper introduces an imaging technique based on circular dichroism second-harmonic generation (CD-SHG) to characterize the 3D distribution of KTP nanocrystals. The circular dichroism analysis can probe the orientation of KTP samples, and the research results show that the azimuthal angle is related to the excitation polarization, refractive index mismatches, and imaging depth.
FRONTIERS IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Fan Yang, Cristian Ciraci
Summary: We present a theoretical study on second-harmonic generation from a singular metasurface, which strongly interacts with incident light and generates intense surface polarization, resulting in the generation of second-harmonic field. By using transformation optics, the calculation of nonlinear optical response is simplified, and the dependence on the incident angle is weak, making it potentially useful for all-angle harmonic generation. Furthermore, we investigate the symmetry dependence of second-harmonic generation in the far field and demonstrate an enhanced conversion efficiency under normal incidence by breaking the surface inversion symmetry.
Article
Engineering, Electrical & Electronic
Guangxing Wang, Huiling Zhan, Tianyi Luo, Bingzi Kang, Xiaolu Li, Gangqin Xi, Zhiyi Liu, Shuangmu Zhuo
Summary: Surgery is a crucial method for treating ovarian cancer, but conventional biopsies for intraoperative histopathological diagnosis are labor-intensive, time-consuming, and prone to bias. Therefore, we propose a novel optical biopsy method using deep learning techniques to assist physicians in accurately and rapidly diagnosing ovarian cancer during surgery.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Young Chul Kim, Hoseong Yoo, Van Tu Nguyen, Soonil Lee, Ji-Yong Park, Yeong Hwan Ahn
Summary: In this study, a high-speed second-harmonic generation (SHG) imaging technique was used for in situ characterization of transition-metal dichalcogenide (TMD) monolayers and twisted bilayers. The SHG imaging allowed rapid identification of crystallinity, orientation, and homogeneity of the TMD with a speed of 1 frame/s. The research also revealed the SHG peak intensity and angles variation with the twist angle in twisted bilayer MoS2 under strong interlayer coupling, as well as the threshold behavior of laser-induced ablation in MoS2 monolayers and bilayers.
Article
Multidisciplinary Sciences
Shingo Toyoda, Manfred Fiebig, Taka-hisa Arima, Yoshinori Tokura, Naoki Ogawa
Summary: Mirror symmetries play a crucial role in fundamental properties and conservation laws, with potential magnetoelectric cross-coupling when both spatial inversion and time reversal are broken. The giant nonreciprocal optical response observed in SHG of CuB2O4 is due to interference between magnetic-dipole and electric-dipole contributions, showing the potential for nonreciprocal nonlinear optical functionalities in multiferroics and magnetoelectrics. Resonantly enhanced magnetic-dipole transitions contribute significantly to the nonreciprocity, maximizing the effect despite the inherently weaker nature compared to electric-dipole transitions.
Article
Multidisciplinary Sciences
Shivangi Shree, Delphine Lagarde, Laurent Lombez, Cedric Robert, Andrea Balocchi, Kenji Watanabe, Takashi Taniguchi, Xavier Marie, Iann C. Gerber, Mikhail M. Glazov, Leonid E. Golub, Bernhard Urbaszek, Ioannis Paradisanos
Summary: Efficient second-harmonic generation (SHG) occurs for crystals with broken inversion symmetry, such as transition metal dichalcogenide monolayers. Here the authors show SHG tuning in bilayer MoS2 - an inversion-symmetric crystal - mediated by interlayer excitons.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yovan de Coene, Stijn Jooken, Olivier Deschaume, Valerie Van Steenbergen, Pieter Vanden Berghe, Chris Van den Haute, Veerle Baekelandt, Geert Callewaert, Stijn Van Cleuvenbergen, Thierry Verbiest, Carmen Bartic, Koen Clays
Summary: In this study, it is found that endogenous second-harmonic generation (SHG) from live cells is highly sensitive to changes in transmembrane potential (TMP), indicating the potential of using SHG as a label-free read-out tool for electrogenic cells.