Article
Biochemistry & Molecular Biology
Joo Mi Yi, Tae-Hong Kang, Yu Kyeong Han, Ha Young Park, Ju Hwan Yang, Jin-Han Bae, Jung-Soo Suh, Tae-Jin Kim, Joong-Gook Kim, Yan-Hong Cui, Hiromu Suzuki, Kohei Kumegawa, Sung Joo Kim, Yi Zhao, In Ja Park, Seung-Mo Hong, Joon-Yong Chung, Su-Jae Lee
Summary: This study identifies Neuralized (NEURL) as a novel tumor suppressor gene that targets oncogenic Wnt/beta-catenin signaling in human cancers. NEURL expression is epigenetically regulated and suppressed in colorectal cancer. NEURL acts as an E3 ubiquitin ligase, interacting with oncogenic beta-catenin and reducing its cytoplasmic levels, thereby disrupting the canonical Wnt/beta-catenin pathway.
Article
Oncology
Yajun Luo, Siqi Huang, Jinlai Wei, He Zhou, Wuyi Wang, Jianguo Yang, Qican Deng, Hao Wang, Zhongxue Fu
Summary: This study reveals that the high expression of LINC01606 is closely associated with poor prognosis in colon cancer. LINC01606 promotes tumor cell proliferation and invasion by regulating miR-423-5p and the Wnt/β-catenin pathway, while inhibiting ferroptosis. It is a potential therapeutic target for colon cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jia Liu, Xiufeng Chen, Xianrong Zhou, Ruokun Yi, Zhennai Yang, Xin Zhao
Summary: The study showed that L. fermentum ZS09 could inhibit the EMT and angiogenesis pathways by suppressing the Wnt/beta-catenin signalling pathway, thus inhibiting tumor metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Lubna M. Mehdawi, Souvik Ghatak, Payel Chakraborty, Anita Sjolander, Tommy Andersson
Summary: This study finds that WNT5A signaling inhibits colon cancer stemness and VEGFA expression by suppressing the expression of LGR5/RSPO3 and beta-catenin activity. This provides clues for developing new strategies to treat colon cancer.
Article
Food Science & Technology
Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang
Summary: Gloeostereum incarnatum polysaccharides (GIPS) exhibit anti-colon cancer effects by regulating cytokines and the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory and tumor growth inhibition properties.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Feng Luan, Lei Wang, Xue-Feng Gai
Summary: CAMTA2 is highly expressed in colon cancer and correlated with poor survival. miR-28-5p regulates CAMTA2 expression in colon cancer. The miR-28-5p/CAMTA2 axis plays a critical role in human colon cancer development and may be a potential target for diagnosis and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Cell Biology
Roozbeh Akhavanfar, Seyyed-Ghavam Shafagh, Behnood Mohammadpour, Yalda Farahmand, Mohammad Hassan Lotfalizadeh, Keihan Kookli, Ali Adili, Goli Siri, Seyed Mahmoud Eshagh Hosseini
Summary: Gastric cancer is a prevalent malignancy worldwide, with poor prognosis and management despite therapeutic advances. The Wnt/beta-catenin pathway is an important target for gastric cancer treatment. Non-coding RNAs play crucial roles in gene regulation and are involved in signaling pathways such as Wnt/beta-catenin. Understanding the role of these regulatory molecules in gastric cancer development may lead to the identification of potential therapeutic targets.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Amira Abdelwhab, Olfat Shaker, Reham Lotfy Aggour
Summary: This study evaluated the expression level of mucin1 in saliva and its correlation with clinical and histological variables in oral potentially malignant disorders and oral squamous cell carcinoma patients. The results showed that mucin1 expression in saliva was significantly elevated in both oral potentially malignant disorders and oral squamous cell carcinoma patients compared with controls, and it correlated with the severity and metastasis of the diseases. These findings suggest that mucin1 in saliva may serve as a potential biomarker for diagnosing these oral diseases.
Article
Biochemistry & Molecular Biology
Ebtsam Hamed Khalil, Olfat G. Shaker, Nabil A. Hasona
Summary: Cancer is a major public health issue globally, and this study aimed to investigate the role of LncRNA H-19 rs2107425 and miR-200a in colorectal cancer susceptibility and correlation in patients with CRC.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2023)
Letter
Dermatology
Mohamed H. M. EL-Komy, Heba Ahmed, Ahmed Mourad, Olfat Gamil Shaker, Aya M. AlOrbani
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2022)
Article
Cell Biology
Rana Aldabbas, Olfat G. Shaker, Manal F. Ismail, Nevine Fathy
Summary: This study identified the downregulation of miRNA-559 and upregulation of MTDH in psoriatic patients. The levels of PTEN, AKT, and FOXO1 were also found to be significantly altered in psoriasis. miRNA-559 and MTDH may serve as potential diagnostic biomarkers for psoriasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Letter
Dermatology
Mohammed Hussein Medhat EL-Komy, Khadiga S. S. Sayed, Wedad Z. Z. Mostafa, Olfat Shaker, Nada Nasser, Mohammed Hassan
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ghada Ayeldeen, Olfat G. Shaker, Ahmed M. Khairy, Asharef Y. Elfert, Nabil A. Hasona
Summary: Obesity is associated with a higher risk of colorectal cancer, and chronic inflammation plays a role in this association. The study examines the clinical relevance of microRNA expression and TGF-beta/IL-6 axis in obesity-related colorectal cancer. Diseased individuals showed increased expression of IL-6 and TGF-beta, as well as tumor biomarkers. Obese patients with colorectal cancer had lower expression of microRNAs and a negative correlation with BMI.
NON-CODING RNA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Christine Raouf George Mikhail, Abeer Abd El Maksoud Mohamed, Olfat Gamil Shaker, Eman EL Desouky, Rania Hassan Shalaby
Summary: This study suggests that middle income, previous history of H. pylori, and clinical symptoms of dyspepsia are risk factors for oral H. pylori infection. The prevalence of H. pylori infection in Egypt has declined.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Sameh Fayek GamalEl Din, Olfat Gamil Shaker, Ahmad Fawzy Megawer, Mohamed Ahmed Abdel Salam, Abdelhalim Nabil Abdelhalim, Ahmed Adel
Summary: This study compared the levels of Gal-1 and Gal-3 in seminal plasma and serum between azoospermic patients and fertile men. The results showed significantly higher levels of Gal-1 and Gal-3 in the serum and seminal fluid of azoospermic patients. In healthy individuals, there were significant correlations between these levels and age and reproductive hormones.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Chemistry, Multidisciplinary
Abeer Abd Elmoneam Ali, Salwa M. El-Hallouty, Mohammed Ali El-Desouky
Summary: This study aimed to investigate the role of Punica granatum and Persea Americana extracts in decreasing the neurodegenerative effects of AlCl3 toxicity. The results showed that the treatment with Punica granatum and Persea Americana extracts alleviated the adverse effects of AlCl3 and enhanced dopamine levels while reducing apoptotic markers.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Naglaa Mohamed El-Wakeel, Zienab Farid Shalaby, Rania Farouk Abdulmaguid, Sally Said Abd Elhamed, Olfat Shaker
Summary: This study aimed to investigate the levels of prolactin (PRL) in gingival crevicular fluid (GCF), synovial fluid, and serum in patients with moderately active rheumatoid arthritis (RA) with and without periodontitis (P). The study found that patients with periodontitis had higher levels of PRL in GCF and serum, and non-surgical periodontal treatment could reduce these levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, Research & Experimental
Maysa M. Haroon, Gehan A. Hegazy, Mohammed A. Hassanien, Olfat Shaker, Wafaa H. Hussein
Summary: IL23 levels are significantly elevated in SLE patients compared to healthy individuals and are positively correlated with disease activity and parameters of nephritis. Further research is needed to explore its exact role in SLE pathogenesis and its potential as a biomarker or therapeutic target.
BIOLOGICS-TARGETS & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Elsayed Fouad, Mohamed Abd El-Moneim, Mahmoud El-Desouky, W. I. El-Dougdoug
Summary: New chitosan derivatives were synthesized and evaluated as corrosion inhibitors for mild steel in acidic medium. The inhibition efficiency of these derivatives was found to be high and they were capable of forming a protective film to reduce the corrosion rate.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed Abdel-Aziz, Mahmoud El-Fransawy, Mahmoud El-Desouky, Rasha A. El-Sadany
Summary: This study investigates the effects of gamma radiation on normal weight concrete and heavyweight concrete, as well as the possibility of replacing steel bars with carbon glass fiber reinforced polymer bars. The results show that heavyweight concrete mixed with barite and ilmenite has better radiation properties than normal weight concrete, and carbon glass fiber bars can safely replace steel bars in structures exposed to gamma radiations.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
