Article
Gastroenterology & Hepatology
Vanessa Koo, Feng Tian, William W. L. Wong
Summary: HCV point-of-care testing is cost-effective for injection drug users, as it can prolong individuals' lifespan and save healthcare costs associated with HCV-related complications.
LIVER INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Nora Schmit, Shevanthi Nayagam, Maud Lemoine, Gibril Ndow, Yusuke Shimakawa, Mark R. Thursz, Timothy B. Hallett
Summary: This study aimed to assess the impact and cost-effectiveness of different monitoring strategies for HBV-infected individuals. The findings showed that monitoring every 5 years for 15-45 year olds in a community-based screening program in The Gambia was the most cost-effective strategy.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Gastroenterology & Hepatology
Hye Won Lee, Hankil Lee, Beom Kyung Kim, Young Chang, Jae Young Jang, Do Young Kim
Summary: Hepatitis C virus (HCV) infection is the second leading cause of chronic liver disease in South Korea, with a prevalence ranging from 0.6% to 0.8%, and the incidence increases with age. The underdiagnosis of HCV is a major barrier to elimination, and universal screening for HCV in adults has been suggested to improve detection. Recent studies have shown that universal screening and treatment using direct-acting antivirals are cost-effective approaches for prevention and treatment of HCV infection.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Nor Zam Azihan Mohd Hassan, Asmah Razali, Mohd Ridzwan Shahari, Mohd Shaiful Jefri Mohd Nor Sham Kunusagaran, Juanita Halili, Nur Amalina Zaimi, Mohd Shahri Bahari, Farhana Aminuddin
Summary: The study in Malaysia found that screening for tuberculosis among high-risk groups, focusing on people living with HIV, was the most cost-effective strategy. Additionally, screening among the elderly, prisoners, and smokers also proved to be cost-effective methods.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Lukas E. Bruemmer, Ryan R. Thompson, Akash Malhotra, Sourya Shrestha, Emily A. Kendall, Jason R. Andrews, Patrick Phillips, Payam Nahid, Adithya Cattamanchi, Florian M. Marx, Claudia M. Denkinger, David W. Dowdy
Summary: Low-complexity screening tests for tuberculosis (TB) have the potential to expand community-based case-finding efforts, but their costs and cost-effectiveness are not well understood.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Jisoo A. Kwon, Georgina M. Chambers, Fabio Luciani, Lei Zhang, Shamin Kinathil, Dennis Kim, Hla-Hla Thein, Willings Botha, Sandra Thompson, Andrew Lloyd, Lorraine Yap, Richard T. Gray, Tony Butler
Summary: This study assessed the impact of increasing direct-acting antiviral (DAA) treatment uptake on hepatitis C virus (HCV) transmission in Australian prisons and found that treating more than 25% of infected prisoners with DAA therapy is highly cost-effective.
Review
Infectious Diseases
H. Alsdurf, B. Empringham, C. Miller, A. Zwerling
Summary: In high TB burden countries, systematic screening for PLHIV is the most cost-effective approach, while screening for persons with clinical and structural risk factors generally lacks cost-effectiveness. The study emphasizes the importance of TB programs focusing on simple, cheaper initial screening tools and utilizing molecular diagnostic tools for high-risk groups to improve cost-effectiveness.
BMC INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
A. Georgieva, A. Atanassova, M. Mirchev
Summary: This study aims to determine the incidence of tuberculosis infection (TBI) among Crohn's disease (CD) patients receiving anti-TNF-alpha therapy. The study found that a significant proportion of patients had latent tuberculosis infection (LTBI) before starting the biological treatment, and about 21.6% of patients were newly diagnosed with LTBI during the treatment. Therefore, LTBI screening is essential before initiating immunosuppressive and biological treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hye-Lin Kim, Kyung-Ah Kim, Gwang Hyun Choi, Eun Sun Jang, Moran Ki, Hwa Young Choi, Sook-Hyang Jeong
Summary: This study evaluates the cost-effectiveness of hepatitis C virus (HCV) screening compared to no screening in the Korean population. It finds that one-time universal HCV screening is highly cost-effective from both healthcare system and societal perspectives.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Rheumatology
Aysa Hacioglu, Sermin Borekci, Melike Melikoglu, Yesim Ozguler, Sinem Nihal Esatoglu, Serdal Ugurlu, Emire Seyahi, Izzet Fresko, Vedat Hamuryudan, Huri Ozdogan, Sebahattin Yurdakul, Ibrahim Hatemi, Aykut Ferhat Celik, H. Gul Ongen, Gulen Hatemi
Summary: In candidates for TNF-alpha inhibitor treatment, BCG vaccination and male sex were associated with positive TST, while prednisolone and azathioprine were associated with negative TST. Despite the increased use of isoniazid with TST, it was generally well tolerated by patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Lijun Song, Xuemei Zhu, Yujing Zhou, Yuxuan Feng, Guiqin Dai, Jiabo Chen, Yang Chen, Feng Li, Wenchang Zhao
Summary: The study introduced a RV-infected zebrafish model, successfully establishing a model highly consistent with clinical infection in infants, and identified the potential of the model for antiviral drug assessment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Infectious Diseases
Giulia Russo, Valentina Marchese, Beatrice Formenti, Claudia Cimaglia, Gianluca Di Rosario, Irene Cristini, Paola Magro, Issa El-Hamad, Daniela Maria Cirillo, Enrico Girardi, Alberto Matteelli
Summary: Screening for tuberculosis infection among migrants from high-incidence countries is crucial for tuberculosis control in low-incidence countries. However, the optimal screening strategy has not been defined yet. This study compared the completion rate, time to completion, preventive treatment initiation rate, and cost-effectiveness of two strategies and found that the sequential strategy had higher cost-effectiveness, despite lower completion rate. Therefore, implementing the sequential strategy among migrants may be justified.
Article
Biochemistry & Molecular Biology
Chansu Lee, Sung-Noh Hong, Eun-Ran Kim, Dong-Kyung Chang, Young-Ho Kim
Summary: Patients with Crohn’s disease exhibit reduced epithelial proliferation and wound healing ability in intestinal organoids, potentially due to decreased cell proliferation. The study findings suggest impaired epithelial regeneration ability in patients with CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ming-Ying Lu, Ming-Lun Yeh, Ching- Huang, Shu-Chi Wang, Yi-Shan Tsai, Pei-Chien Tsai, Yu-Min Ko, Ching-Chih Lin, Kuan-Yu Chen, Yu-Ju Wei, Po-Yao Hsu, Cheng-Ting Hsu, Tyng-Yuan Jang, Ta-Wei Liu, Po-Cheng Liang, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
Summary: Chronic hepatitis C virus (HCV) infection induces changes in cytokine expression, and this study found that downregulation of TNF-alpha significantly increases the risk of hepatocellular carcinoma (HCC) after successful antiviral therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Antoine Chaillon, Adriane Wynn, Tatyana Kushner, Nancy Reau, Natasha K. Martin
Summary: The study suggests that universal HCV rescreening for pregnant women without evidence of HCV from prior pregnancies is cost-effective and should be recommended nationwide.
CLINICAL INFECTIOUS DISEASES
(2021)