Review
Chemistry, Analytical
Haonan Li, Yuxi Fang, Junjie Yan, Xiangyu Ren, Chao Zheng, Bo Wu, Siyuan Wang, Zhanlin Li, Huiming Hua, Peng Wang, Dahong Li
Summary: Hydrogen sulfide (H2S) is considered as another gasotransmitter involved in important physiological and pathological processes. To real-time detect H2S in biological systems, numerous small-molecule fluorescent probes have been developed, with improvements in selectivity, response capability, and optical performance.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Jing Yu, Yanyang Qin, Yuxuan Yang, Xiaodan Zhao, Zixi Zhang, Qiang Zhang, Yaqiong Su, Yanfeng Zhang, Yilong Cheng
Summary: In this study, a potent hydrogel adhesive was developed by free radical polymerization. The hydrogel exhibited strong adhesive properties and hemostasis effect, making it a promising candidate for emergency rescue and tissue repair applications.
BIOACTIVE MATERIALS
(2023)
Article
Spectroscopy
Pinghua Ou, Yali Wang, Cong Hao, Yongbo Peng, Li-yi Zhou
Summary: Hydrogen sulfide (H2S) is a crucial endogenously generated gaseous signaling molecule, but its physiological and pathological relationship in inflamed tissues is still unclear. A novel two-photon bioimaging probe NP-H2S was developed with improved sensitivity for direct monitoring of H2S in complex biological samples, showing potential for further biological applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Li Li, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Ziqian Zhang
Summary: This study introduces a novel H2S donor, HSD560, which releases H2S triggered by cysteine, accompanied by enhanced green fluorescence for tracking H2S release in cells. The H2S release from HSD560 undergoes a non-enzymatic native chemical ligation process, accurately matching activated fluorescence and localizing H2S in zebrafish.
Review
Biochemistry & Molecular Biology
Kearsley M. Dillon, John B. Matson
Summary: Persulfides have emerged as reactive sulfur species with enhanced antioxidant abilities compared to hydrogen sulfide, but their instability and cross-reactivity hinder the elucidation of their precise biological roles. To facilitate the study of persulfides, chemists have designed various chemical tools and techniques, including persulfide trapping reagents and sensors, as well as persulfide donors that release persulfides in response to triggers.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Physical
Areef Billah, Fumiya Tojo, Shigeru Kubota, Fumihiko Hirose, Bashir Ahmmad
Summary: Organic molecule embedded CdS nanocomposites prepared by the solvothermal method exhibit high efficiency and potential for hydrogen production via water splitting.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Analytical
Archana Panthalattu Parambil, Shanmughan Shamjith, Jais Kurian, Akila Kesavan, Ashis K. Sen, Paul R. Thangaraj, Kaustabh Kumar Maiti, Muraleedharan K. Manheri
Summary: The discovery of the biological signaling roles of H2S has sparked interest in the development of reliable methods for its detection and quantification. Reaction-based probes that respond through 'off-on' fluorescence emission remain the most studied approach. A dual mode response system based on a 1H-pyrrol-3(2H)-one scaffold, which senses H2S through characteristic fluorescence and Raman (SERS) signals, was developed with advantages of fast response and high selectivity and sensitivity. The imaging of H2S in HepG2 cells using the SERS signal from the thiolysis product was also demonstrated.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Yifan He, Wei Hu, Li Chai, Yanying Wang, Xian Wang, Tao Liang, Haiyan Li, Chunya Li
Summary: A cell membrane-targeted near-infrared fluorescent probe, CMCu-H2S, with high selectivity and rapid response rate, was developed for detecting H2S and studying drug resistance and chemotherapy efficacy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Yan Chen, Jia-Jun Deng, Wen-Wen Yao, Joseph Israel Gurti, Wei Li, Wen-Jie Wang, Jian-Xi Yao, Xun-Lei Ding
Summary: Structures of non-stoichiometric MoxSy clusters were studied using density functional calculations, revealing a novel grid structure and the preference of hydrogen molecule adsorption onto Mo atoms. Additionally, vacant bridge sites between Mo-Mo in sulfur-deficient clusters were found to play a crucial role in hydrogen atom adsorption and transfer.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Organic
Qi Cui, Tony W. Pan, Meg Shieh, Shane S. Kelly, Shi Xu, Wei-Jun Qian, Ming Xian
Summary: In this study, we predicted the reactivity of strained alkynes with sulfur-containing analogues through computational studies. Experimental results confirmed the predictions, showing that 2H-pyan-2-thiones were the most reactive substrates. This reaction was effective in aqueous buffers and cellular environments, producing COS as a byproduct which could be converted into H2S.
Article
Chemistry, Multidisciplinary
Kuljeet Kaur, Patrick Enders, Yumeng Zhu, Abigail F. Bratton, Chadwick R. Powell, Khosrow Kashfi, John B. Matson
Summary: A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics was reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Junbin Li, Ying Zhou, Lifei Song, Sheng Yang, Qianqian Wang, Yibo Zhou, Xiao-Bing Zhang, Zhihe Qing, Ronghua Yang
Summary: In this study, a nanobeacon sensitive to hydrogen sulfide (H2S) was developed for monitoring in situ antioxidant fluctuation during epilepsy. The nanobeacon revealed that H2S levels were elevated during mild epilepsy but significantly suppressed during severe epilepsy. This research provides important insights into the pathology of epilepsy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Qikai Ju, Zhen Qiao, Ningning Wei, Yanru Zhang
Summary: In this study, a near-infrared fluorescent probe DCM-NBD is introduced, which shows super-fast response to H2S and has the potential for biological imaging.
Article
Chemistry, Analytical
Jinlong Zhang, Shuai Mu, Yaya Wang, Shuangqin Li, Xuezhao Shi, Xiaoyan Liu, Haixia Zhang
Summary: In this study, a water-soluble fluorescent probe CySO3N3 was developed to visualize the dynamics of hydrogen sulfide (H2S). The probe can effectively detect H2S in living cells and mice, and shows great potential in monitoring H2S changes during inflammation and myocardial injury.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Jihoon Kim, Jinyoung Oh, Min Su Han
Summary: A ratiometric and selective hydrogen sulfide detection probe was developed based on the metal ion displacement mechanism, showing rapid response and high sensitivity with a detection limit of 70 nM. The probe exhibited unchanged monomer emission as an internal reference and enhanced excimer emission with the addition of H2S. The method was successfully applied for detecting H2S in human serum without interference from biological molecules.
