Article
Multidisciplinary Sciences
Majid Ramezani, Mahnaz Reisian, Zohreh Sajadi Hezaveh
Summary: This study investigated the effect of synbiotic supplementation on hypothyroid patients through a double-blind, placebo-controlled, randomized clinical trial. The results showed that a 10-week synbiotic supplementation had no significant effect on thyroid stimulating hormone and free thyroxine, but it improved blood pressure and quality of life.
Article
Nutrition & Dietetics
Chen-Meng Kuan, Chia-Hua Liang, Wei-Hsiu Chuang, Ting-Yu Lin, Pang-Kuei Hsu
Summary: This study investigated the effects of Taiwanese folk medicine Crassocephalum rabens and its primary active compound dLGG on skin conditions in healthy individuals. The results showed significant improvements in skin elasticity, wrinkles, collagen content, brightness, and hydration after treatment with C. rabens extract. This suggests that C. rabens may have potential applications in preventing skin aging.
Article
Food Science & Technology
Abed Ghavami, Fariborz Khorvash, Saman Khalesi, Zahra Heidari, Gholamreza Askari
Summary: Synbiotic supplementation can improve total antioxidant capacity, reduce nitric oxide, oxidative stress index, and migraine index, which may help alleviate migraine symptoms.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Xiaoqin Li, Shan Hu, Jiawei Yin, Xiaobo Peng, Lei King, Linyan Li, Zihui Xu, Li Zhou, Zhao Peng, Xiaolei Ze, Xuguang Zhang, Qiangchuan Hou, Zhilei Shan, Liegang Liu
Summary: In a study involving healthy individuals, synbiotic supplementation was found to have limited immunomodulatory effects. However, participants who received synbiotic supplementation experienced reductions in plasma C-reactive protein and interferon-gamma, as well as increases in plasma interleukin-10 and stool secretory IgA. The supplementation also led to changes in gut microbiota composition, with an enrichment of beneficial bacteria and a reduction in potential pro-inflammatory bacteria. These findings highlight the potential of personalized synbiotic supplementation for immunomodulation.
Article
Nutrition & Dietetics
Piyarat Oraphruek, Charoonsri Chusak, Sathaporn Ngamukote, Vorthon Sawaswong, Prangwalai Chanchaem, Sunchai Payungporn, Tanyawan Suantawee, Sirichai Adisakwattana
Summary: This study aimed to evaluate the effects of a multispecies probiotics mixed with fructooligosaccharides on body composition, antioxidant status, and gut microbiome composition in overweight and obese individuals. The results showed that synbiotic supplementation led to a significant reduction in waist circumference and body fat percentage, as well as improvements in antioxidant capacity and gut microbiota composition. Therefore, multispecies synbiotic supplementation could be a beneficial strategy for improving body composition, antioxidant status, and gut microbiome composition in overweight and obese subjects.
Article
Multidisciplinary Sciences
Audrey M. Neyrinck, Julie Rodriguez, Bernard Taminiau, Camille Amadieu, Florent Herpin, Francois-Andre Allaert, Patrice D. Cani, Georges Daube, Laure B. Bindels, Nathalie M. Delzenne
Summary: This study indicates that a synbiotic approach using Bifidobacterium animalis lactis and fructo-oligosaccharides can significantly improve gastrointestinal health and reduce inflammation in middle-aged individuals. While the treatment did not impact mood, quality of life, or gut microbiota composition, it did lead to a significant decrease in plasma proinflammatory cytokines after 30 days of supplementation.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Franz E. Babl, David Herd, Meredith L. Borland, Amit Kochar, Ben Lawton, Jason Hort, Adam West, Shane George, Michael Zhang, Karthik Velusamy, Frank Sullivan, Ed Oakley, Andrew Davidson, Sandy M. Hopper, John A. Cheek, Robert G. Berkowitz, Stephen Hearps, Catherine L. Wilson, Amanda Williams, Hannah Elborough, Donna Legge, Mark T. Mackay, Katherine J. Lee, Stuart R. Dalziel
Summary: This study aimed to investigate the effect of prednisolone on the recovery of children with Bell palsy through a double-blind, placebo-controlled, randomized trial. The results showed that early treatment with prednisolone did not improve complete recovery in children with Bell palsy, although the study was underpowered.
Article
Medicine, General & Internal
Mark D. DeBoer, James A. Platts-Mills, Sarah E. Elwood, Rebecca J. Scharf, Joann M. McDermid, Anne W. Wanjuhi, Samwel Jatosh, Siphael Katengu, Tarina C. Parpia, Elizabeth T. Rogawski McQuade, Jean Gratz, Erling Svensen, Jonathan R. Swann, Jeffrey R. Donowitz, Paschal Mdoe, Sokoine Kivuyo, Eric R. Houpt, Estomih Mduma
Summary: In this study, neither scheduled administration of azithromycin and nitazoxanide nor daily provision of nicotinamide was associated with improved growth in this resource-poor setting with a high force of enteric infections. Further research remains critical to identify interventions toward improved early childhood growth in challenging conditions.
Article
Gastroenterology & Hepatology
Andrew Fagan, Edith A. Gavis, Mary Leslie Gallagher, Travis Mousel, Brian Davis, Puneet Puri, Richard K. Sterling, Velimir A. Luketic, Hannah Lee, Scott C. Matherly, Arun J. Sanyal, R. Todd Stravitz, Vaishali Patel, Mohammad S. Siddiqui, Amon Asgharpour, Michael Fuchs, Leroy Thacker, Jasmohan S. Bajaj
Summary: This double-blind, placebo-controlled trial aimed to improve cognitive function and psychosocial well-being in patients with chronic liver cirrhosis and minimal hepatic encephalopathy (MHE) by administering albumin infusions. The results showed that the albumin group demonstrated improved cognitive function and psychosocial well-being.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hyung Mook Kim, Yong Moon Lee, Ee Hwa Kim, Sang Won Eun, Hyun Kyung Sung, Heung Ko, Sang Jun Youn, Yong Choi, Wakana Yamada, Seon Mi Shin
Summary: This study evaluated the effects of consuming edible bird's nest extract on skin health and safety in women. The results showed that the extract effectively improved skin wrinkles without causing any adverse reactions. Laboratory tests also indicated no clinically significant differences. Therefore, edible bird's nest extract can be considered a safe and effective skin nutritional supplement.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Nutrition & Dietetics
Sakda Arj-Ong Vallibhakara, Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, Orawin Vallibhakara
Summary: The study suggests that vitamin E (mixed-tocopherol) supplementation may have a preventive effect on bone loss in postmenopausal osteopenic women through anti-resorptive activity.
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Pediatrics
Mohammad Amin Atazadegan, Motahar Heidari-Beni, Mohammad Hassan Entezari, Fariborz Sharifianjazi, Roya Kelishadi
Summary: This study aimed to assess the effect of synbiotic on anthropometric indices and body composition in overweight or obese children and adolescents. The results showed that synbiotic supplementation might be associated with a reduction in waist-height ratio, but no significant changes were found in other anthropometric indices or body composition.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Maja Di Rocco, Eduardo Forleo-Neto, Robert J. Pignolo, Richard Keen, Philippe Orcel, Thomas Funck-Brentano, Christian Roux, Sami Kolta, Annalisa Madeo, Judith S. Bubbear, Jacek Tabarkiewicz, Malgorzata Szczepanek, Javier Bachiller-Corral, Angela M. Cheung, Kathryn M. Dahir, Esmee Botman, Pieter G. Raijmakers, Mona Al Mukaddam, Lianne Tile, Cynthia Portal-Celhay, Neena Sarkar, Peijie Hou, Bret J. Musser, Anita Boyapati, Kusha Mohammadi, Scott J. Mellis, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Gary A. Herman, Sarah J. O'Meara, Richard Delgizzi, David M. Weinreich, George D. Yancopoulos, E. Marelise W. Eekhoff, Frederick S. Kaplan
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by abnormal bone formation in connective tissues and painful flare-ups. Garetosmab, an activin A-blocking antibody, can prevent the formation of new lesions but does not significantly impact the activity of pre-existing lesions.
Article
Gastroenterology & Hepatology
Tamar Ringel-Kulka, Johnson McRorie, Yehuda Ringel
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
John Belmont, Margaret Heitkemper, Tamar Ringel-Kulka, Bruno P. Chumpitazi, Robert J. Shulman
Article
Gastroenterology & Hepatology
Nitsan Maharshak, Yehuda Ringel, David Katibian, Ashley Lundqvist, R. Balfour Sartor, Ian M. Carroll, Tamar Ringel-Kulka
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Nursing
Abigail L. Liberty, Kathryn Wouk, Ellen Chetwynd, Tamar Ringel-Kulka
JOURNAL OF HUMAN LACTATION
(2019)
Article
Gastroenterology & Hepatology
Eyal Zifman, Hagar Banai, Raanan Shamir, Tamar Ringel-Kulka, Noam Zevit
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Review
Medicine, Research & Experimental
Tomasz Dworzanski, Rafal Fornal, Lukasz Kozba, Krzysztof Celinski, Ewa Dworzanska
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2018)
Article
Gastroenterology & Hepatology
Keren Hod, Yehuda Ringel, Miranda A. L. van Tilburg, Tamar Ringel-Kulka
DIGESTIVE DISEASES AND SCIENCES
(2019)
Article
Multidisciplinary Sciences
Pavlo Khodakivskyi, Christian L. Lauber, Aleksey Yevtodiyenko, Arkadiy A. Bazhin, Stephen Bruce, Tamar Ringel-Kulka, Yehuda Ringel, Bertrand Betrisey, Joana Torres, Jianzhong Hu, Chieh Jason Chou, Elena A. Goun
Summary: The study developed a novel optical tool for quantifying BSH activity across various biological contexts in a quick and cost-effective manner, with potential clinical applications, particularly in predicting the clinical status of IBD patients.
Article
Environmental Sciences
Hilde Kristin Vindenes, Cecilie Svanes, Stein Hakon Lastad Lygre, Francisco Gomez Real, Tamar Ringel-Kulka, Randi Jacobsen Bertelsen
Summary: The study investigated the associations between the use of personal care products and urine biomarker levels of phenols and parabens, as well as the potential impact on inflammatory diseases like allergies and overweight. The results showed correlations between several chemicals and conditions such as eczema, rhinitis, asthma, specific IgE, and body mass index.
ENVIRONMENTAL HEALTH
(2021)
Article
Genetics & Heredity
Chris Eijsbouts, Tenghao Zhen, Nicholas A. Kennedy, Ferdinando Bonfiglio, Carl A. Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, Alexandru-loan Voda, Gianrico Farrugia, Andre Franke, Matthias Huebenthal, Goncalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tonu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J. Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Summary: An analysis of the genome-wide association of irritable bowel syndrome has identified and confirmed six genetic susceptibility loci, with implicated genes linked to mood and anxiety disorders. There is a strong correlation between the risk of IBS and anxiety, neuroticism, and depression, suggesting shared pathways with mood and anxiety disorders rather than anxiety directly causing abdominal symptoms.
Article
Art
Tomas Kulka
Summary: Contrary to popular belief, this paper argues that the aesthetic value of artworks has been overrated and that artistic value is equally important. The author suggests that the monetary value of artworks, although not directly related to their aesthetic or artistic value, can provide insights into the overall value and relative importance of these two components.
BRITISH JOURNAL OF AESTHETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Randi Jacobsen Bertelsen, Antonio Manuel Perez Barrionuevo, Rajesh Shigdel, Stein Atle Lie, Huang Lin, Francisco Gomez Real, Tamar Ringel-Kulka, Anne Nordrehaug Astrom, Cecilie Svanes
Summary: Research findings have shown that increasing self-reported gingival bleeding frequency is associated with increased gingival bacterial diversity. Frequent gingival bleeding is associated with increased abundance of certain bacteria (such as Porphyromonas endodontalis, Treponema denticola, and Fretibacterium spp.), but decreased abundance of bacteria within the gram-positive phyla Firmicutes and Actinobacteria. Additionally, using dental floss and mouthwash twice daily is associated with increased total abundance of bacteria in the Proteobacteria phylum, but decreased bacterial diversity.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Microbiology
Hilde Kristin Vindenes, Huang Lin, Rajesh Shigdel, Tamar Ringel-Kulka, Francisco Gomez Real, Cecilie Svanes, Shyamal D. Peddada, Randi J. Bertelsen
Summary: This study explores the impact of antimicrobial and environmental chemicals on the composition of oral bacteria. The results show that high levels of certain chemicals are associated with changes in the abundance of oral bacteria, highlighting the need for a better understanding of how antimicrobial chemical exposure influences the human microbiome.
FRONTIERS IN MICROBIOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Yehuda Ringel, Chieh J. Chou, Stephen J. Bruce, Hugues Henry, Christian Lauber, Bertrand Betrisey, Elena Goun, Tamar Ringel-Kulka
Article
Materials Science, Multidisciplinary
M. Rossi, M. Retegan, C. Giacobbe, R. Fumagalli, A. Efimenko, T. Kulka, K. Wohlfeld, A. I. Gubanov, M. Moretti Sala
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)