Editorial Material
Microbiology
Darin L. Wiesner
Summary: Candida albicans in the gut serves as a mutualist by stimulating the immune system to produce antibodies that protect against invasive fungal infections, revealing a previously unknown beneficial role of this fungus in the body.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Jianfeng Mu, Jiaxing Song, Rong Li, Tianyi Xue, Dongxu Wang, Jinhai Yu
Summary: This study found that isovitexin (ISO) can attenuate DSS-induced colitis by activating aryl hydrocarbon receptor (AhR) and protecting the integrity of the intestinal barrier. Therefore, ISO may be a potential therapeutic agent for colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Infectious Diseases
Yuankang Zhou, Yuheng Luo, Bing Yu, Ping Zheng, Jie Yu, Zhiqing Huang, Xiangbing Mao, Junqiu Luo, Hui Yan, Jun He
Summary: The study found that supplementation of BGL has a positive impact on the growth performance and intestinal epithelium functions of weaned pigs challenged with ETEC, attenuating intestinal damage, increasing serum immunoglobulin levels, suppressing the secretion of inflammatory cytokines, and improving intestinal epithelium functions and microbiota.
Article
Engineering, Environmental
Liwen Zhang, Dong Cheng, Jing Zhang, Hui Tang, Fenghua Li, Yi Peng, Xinglan Duan, En Meng, Cuili Zhang, Tao Zeng, Fuyong Song, Jia-Sheng Wang, Xiulan Zhao, Jun Zhou
Summary: We found that the macrophage AHR/TLR/STAT signaling axis is involved in colon colitis induced by the non-canonical AHR ligand aflatoxin B1 (AFB1). In mice exposed to AFB1, there was severe colitis characterized by increased recruitment of myeloid immune cells and tissue damage. In human macrophage models, the exposure to AFB1 resulted in functional changes, overall inflammation, disruption of mitochondrial function, and perturbation of the AHR/TLR/STAT3 signaling axis. Our study suggests that targeting this signaling axis may be a potential intervention for colitis caused by AFB1 exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Dang Hieu Hoang, Minhyeok Song, Lochana Mangesh Kovale, Quynh Hoa Tran, Wonchae Choe, Insug Kang, Sung Soo Kim, Joohun Ha
Summary: This study found that beta-naphthoflavone enhances the efficacy of doxorubicin in lung cancer cells by inducing doxorubicin accumulation, mitochondrial ROS generation, and JNK pathway signaling. Additionally, beta-naphthoflavone synergistically induces apoptosis in lung cancer cells when combined with other cancer drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Konrad A. Szychowski, Bartosz Skora, Anna K. Wojtowicz
Summary: Epidemiological studies have shown that triclosan (TCS) can be found in the brain due to its widespread use as an antibacterial ingredient. One of the mechanisms of its action is the interaction with the aryl hydrocarbon receptor (AhR). In nerve cells, Sirt1 and Sirt3 act as cellular sensors and regulate metabolic processes. The aim of this study was to evaluate the effect of TCS on the production of neurosteroids in primary neural cortical neurons. The results showed that short and long exposure to TCS increased the expression of Sirt1 and Sirt3 proteins in response to AhR stimulation. However, prolonged exposure to TCS decreased the levels of neurosteroids in the cells.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sidrah Khan, Heather L. Mentrup, Elizabeth A. Novak, Vei Shaun Siow, Qian Wang, Erin C. Crawford, Corinne Schneider, Thomas E. Comerford, Brian Firek, Matt B. Rogers, Patricia Loughran, Michael J. Morowitz, Kevin P. Mollen
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the gastrointestinal tract, and dysregulation of intestinal epithelial homeostasis is crucial in its pathogenesis. The study demonstrates the key role of cGAS in maintaining intestinal homeostasis by upregulating Beclin-1-mediated autophagy, and deficiency of cGAS leads to worsened colitis.
Article
Physiology
Sebastian L. Johnston, David L. Goldblatt, Scott E. Evans, Michael J. Tuvim, Burton F. Dickey
Summary: Airway epithelial cells sense and respond defensively to pathogens, with specificity for different pathogen classes. Type 1 immune responses target intracellular pathogens like viruses, while Type 2 responses target helminths and fungi, and Type 3 responses target extracellular microbial pathogens. These responses involve changes in gene expression, release of cytokines, and induction of immune responses to resist infection.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Thomas Plante-Bordeneuve, Charles Pilette, Antoine Froidure
Summary: The interaction between lung epithelium and the immune system plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Pathways such as DAMPs-PAMPs are highlighted as potential mechanisms involved in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fernando A. Vicentini, Alexander J. Mathews, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey, Simon A. Hirota
Summary: The intestinal microbiota influences brain functions and behavior, with the aryl hydrocarbon receptor (Ahr) playing a crucial role in modulating microbiota-related alterations in behavior in male and female mice. Ahr activation can normalize despair behavior induced by antibiotic treatment, suggesting Ahr as a potential modulator of behavioral conditions influenced by the intestinal microbiota.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Yue Chen, Yadong Wang, Yawei Fu, Yulong Yin, Kang Xu
Summary: Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that plays a crucial role in regulating intestinal immunity and inflammation. Activation of AHR can have beneficial effects on the gut, but excessive or sustained activation can lead to immune dysregulation and intestinal diseases. The synthetic ligand TCDD has significant immunotoxic effects and impairs the intestinal epithelial barrier when it activates AHR.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Danika S. Bakke, Jilei Zhang, Yongguo Zhang, Destiny Ogbu, Yinglin Xia, Jun Sun
Summary: Cross talk between immune cells and the intestinal crypt is critical in maintaining intestinal homeostasis. Recent studies have found that vitamin D receptor (VDR) signaling plays a direct role in intestinal and microbial homeostasis, but the specific role of immune VDR signaling is still not well understood. This study used a myeloid-specific VDR knockout mouse model and a macrophage/enteroids coculture system to investigate the tissue-specific VDR signaling in intestinal homeostasis. The findings showed that myeloid VDR regulates crypt differentiation and the microbiota in a VDR-dependent mechanism, and dysregulation of myeloid VDR increases the risk of colitis-associated diseases.
Article
Gastroenterology & Hepatology
Xin Zhang, Xiuting Liu, Wei Zhou, Qianming Du, Mengdi Yang, Yang Ding, Rong Hu
Summary: This study identified the role of kynurenine (Kyn) and indoleamine 2,3-dioxygenase (IDO) in regulating tumor-infiltrating T cells and adaptive immunity in colorectal cancer (CRC). Inhibition of IDO diminished Kyn/AhR-mediated regulatory T cell (Treg) differentiation, providing a potential strategy for the prevention and treatment of inflammation-related colon cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yalan Lu, Rong Huang, Jianming Ying, Xingchen Li, Tao Jiao, Lei Guo, Haitao Zhou, Han Wang, Amannisa Tuersuntuoheti, Jianmei Liu, Qichen Chen, Yanhong Wang, Luying Su, Changyuan Guo, Fu Xu, Ziyi Wang, Yan Lu, Kai Li, Junbo Liang, Zhen Huang, Xiao Chen, Jinjie Yao, Hanjie Hu, Xiaowen Cheng, Yufeng Wan, Xinyan Chen, Ning Zhang, Shiying Miao, Jianqiang Cai, Linfang Wang, Changzheng Liu, Wei Song, Hong Zhao
Summary: This study identified the critical role of RNF138 in colorectal cancer (CRC) tumorigenesis and the suppression of tumor growth through inhibition of NF-kB signaling pathway. Clinical observations also revealed a significant correlation between the downregulation of RNF138 and reinforced NF-kB signaling, as well as poor prognosis. Therefore, RNF138 may serve as an indicator for therapeutic intervention targeting NF-kB signaling.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biology
Xiaodan Liao, Zhongpu Zhao, Hui Li, Bo Wu, Jiawei Huo, Lei Li, Xue Li, Xinran Cao, Min Xia, Chunru Wang, Chunli Bai
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease without an effective cure, but a novel therapeutic strategy using C-60 fullerene suspension (C60FS) has shown promising results in an animal model. C60FS can repair colon barrier dysfunction, promote ulcer healing, reduce inflammation, and inhibit the expression of certain receptors and inflammatory markers in colorectal tissues. This study provides a reliable strategy based on fullerene for treating UC and offers a novel approach for UC therapy.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Shin Nishiumi, Seiji Fujigaki, Takashi Kobayashi, Takashi Kojima, Yoshinori Ito, Hiroyuki Daiko, Ken Kato, Hirokazu Shoji, Yuzo Kodama, Kazufumi Honda, Masaru Yoshida
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Ryoma Tagawa, Yuki Kawano, Akihiro Minami, Shin Nishiumi, Yoshihiko Yano, Masaru Yoshida, Yuzo Kodama
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Cell Biology
Naoyuki Sugiyama, Satomi Miyake, Miao-Hsia Lin, Masaki Wakabayashi, Hiroyuki Marusawa, Shin Nishiumi, Masaru Yoshida, Yasushi Ishihama
Article
Chemistry, Analytical
Shin Nishiumi, Tomohiro Kohata, Takashi Kobayashi, Yuzo Kodama, Sumio Ohtsuki, Masaru Yoshida
Article
Oncology
Takao Iemoto, Shin Nishiumi, Takashi Kobayashi, Seiji Fujigaki, Tetsuya Hamaguchi, Ken Kato, Hirokazu Shoji, Yasuhiro Matsumura, Kazufumi Honda, Masaru Yoshida
Article
Nutrition & Dietetics
Shin Nishiumi, Yoshihiro Izumi, Takashi Kobayashi, Masaru Yoshida
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Koki Matsuoka, Shin Nishiumi, Masaru Yoshida, Yuzo Kodama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Madoka Nambu, Shin Nishiumi, Takashi Kobayashi, Takeshi Masuda, Shingo Ito, Masaru Yoshida, Sumio Ohtsuki
JOURNAL OF PROTEOMICS
(2020)
Article
Medicine, Research & Experimental
Ryota Nakano, Shin Nishiumi, Takashi Kobayashi, Takuya Ikegawa, Yuzo Kodama, Masaru Yoshida
BIOMARKERS IN MEDICINE
(2020)
Article
Oncology
Yu Sato, Takashi Kobayashi, Shin Nishiumi, Akihiko Okada, Tsuyoshi Fujita, Tsuyoshi Sanuki, Masao Kobayashi, Masakyo Asahara, Masayasu Adachi, Arata Sakai, Hideyuki Shiomi, Atsuhiro Masuda, Masaru Yoshida, Keiko Takeuchi, Yuzo Kodama, Hiromu Kutsumi, Kengo Nagashima, Kazufumi Honda
Article
Cell Biology
Takashi Nakanishi, Hirokazu Fukui, Xuan Wang, Shin Nishiumi, Haruka Yokota, Yutaka Makizaki, Yoshiki Tanaka, Hiroshi Ohno, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa
Summary: High-fat diet-induced dysbiosis in the small intestine leads to pathological changes in the luminal environment, disruption of small-intestinal mucosal integrity, and minimal inflammation in the gut-liver axis, ultimately resulting in the development of steatohepatitis in mice.
Article
Biochemistry & Molecular Biology
Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M. Tokuoka, Yoshihiro Kita, Fumie Hamano, Nobuyuki Okahashi, Kazutaka Ikeda, Hiroki Nakanishi, Kosuke Saito, Masami Yokota Hirai, Masaru Yoshida, Yoshiya Oda, Fumio Matsuda, Takeshi Bamba
Summary: In mass spectrometry-based metabolomics, the differences in analytical results from different laboratories/machines are a concern. This study evaluates inter-laboratory differences in metabolomic analysis and finds that the variations are primarily due to measurement and data analysis rather than sample preparation. These findings are important for understanding the challenges in metabolomics studies involving multiple laboratories.
Meeting Abstract
Gastroenterology & Hepatology
K. Honda, T. Kobayashi, Y. Sato, S. Nishiumi, S. Okaya, K. Takeuchi, K. Nagashima, M. Yoshida
Article
Food Science & Technology
Shin Nishiumi, Yoshihiro Izumi, Takashi Kobayashi, Masaru Yoshida
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2019)
Meeting Abstract
Gastroenterology & Hepatology
I. Kobayashi, K. Hanada, M. Fukuyo, K. Yahara, H. Yonezawa, Venclovas, Y. Katsura, A. Toyoda, S. Nishiumi, T. Azuma, M. Kato