Article
Environmental Sciences
Aalekhya Reddam, Andreas Sjodin, Whitney Cowell, Richard Jones, Shuang Wang, Frederica Perera, Julie B. Herbstman, Allison Kupsco
Summary: This study found associations between exposure to polybrominated diphenyl ethers (PBDEs) and birth outcomes in a cohort of Dominican and African American newborns, mainly affecting birth weight and length.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Stephanie M. Eick, Dana E. Goin, Lara Cushing, Erin DeMicco, June-Soo Park, Yunzhu Wang, Sabrina Smith, Amy M. Padula, Tracey J. Woodruff, Rachel Morello-Frosch
Summary: Our study found a positive association between PFAS and PBDEs and newborn telomere length, particularly with PFAS exposure. Prenatal exposure to PFAS and PBDEs may have potential effects on newborn health.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Naomi Azar, Linda Booij, Gina Muckle, Tye E. Arbuckle, Jean R. Seguin, Elizabeth Asztalos, William D. Fraser, Bruce P. Lanphear, Maryse F. Bouchard
Summary: The study found that prenatal exposure to background levels of PBDEs, especially BDE-47, was associated with lower IQ scores in boys, but not in girls. This suggests that exposure to PBDEs during early development may have a sex-dependent and detrimental effect on a child's neurodevelopmental trajectory.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Yi Hu, Qi Lu, Chuican Huang, Yu Gao, Ying Tian, Lichun Fan, Shijian Liu
Summary: The study found positive associations between prenatal PBDE exposure and child weight and height, with these associations varying based on the child's sex, being positive in boys and negative in girls.
Article
Environmental Sciences
Allison Kupsco, Andreas Sjodin, Whitney Cowell, Richard Jones, Sharon Oberfield, Shuang Wang, Lori A. Hoepner, Dympna Gallagher, Andrea A. Baccarelli, Jeff Goldsmith, Andrew G. Rundle, Julie B. Herbstman
Summary: Data collected from a birth cohort in New York City revealed that prenatal PBDE exposures were not associated with child growth trajectories in Dominican and African American children. The study found no significant impact of cord levels of individual PBDEs or total PBDE mixture on childhood BMIz. Adjusting for postnatal PBDE exposures did not alter the results.
ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Min Luan, Honglei Ji, Maohua Miao, Hong Liang, Ziliang Wang, Yafei Chen, Aimin Chen, Wencheng Cao, Wei Yuan
Summary: The study found a positive association between prenatal exposure to polybrominated diphenyl ethers (PBDEs) and anogenital distance (AGD) in girls aged 0-4 years, with stronger correlations observed at 6 months and 48 months of age.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Mantong Jin, Shunfei Zhang, Jiaqi He, Zhuhao Lu, Shanshan Zhou, Nanxi Ye
Summary: The study investigated PBDE contamination in the microenvironment of family automobiles in Hangzhou City, China. Decabromodiphenyl ether (BDE-209) was found to be the major component, primarily sourced from volatile polyurethanes in seat covers and foot pads. Infants and toddlers were most exposed to PBDEs, with BDE-47 and -99 posing the primary health risks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Limei Chen, Qitao Yin, Lu Xu, Minyu Hua, Zhen Zhang, Yuqian Xu, Wei Xia, Huizhong Qian, Jun Hong, Jun Jin
Summary: This study aims to analyze the concentrations of polybrominated diphenyl ethers (PBDEs) in a population of blood donors over a 4-year period and evaluate their temporal trends. The median concentrations of PBDEs showed a downward trend from 2013 to 2014 and then increased after 2014. There were no correlations between age and PBDE congener concentrations, while concentrations were generally lower in females than in males.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Kim Hartley, Melinda C. MacDougall, Brandon Terrizzi, Yingying Xu, Kim M. Cecil, Aimin Chen, Joseph M. Braun, Bruce P. Lanphear, Nicholas C. Newman, Ann M. Vuong, Andreas Sjodin, Kimberly Yolton
Summary: The study found that gestational exposure to polybrominated diphenyl ethers (PBDEs) had negative effects on behavioral outcomes in males, but no significant associations were observed in females.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Qian Yao, Angela Vinturache, Xiaoning Lei, Zixia Wang, Chengyu Pan, Rong Shi, Tao Yuan, Yu Gao, Ying Tian
Summary: This study found potential associations between prenatal PFAS exposure and early neurodevelopmental deficiencies, particularly in the gross motor domain. The associations were partly explained by thyroid hormone mediator effects.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Ann M. Vuong, Glenys M. Webster, Kimberly Yolton, Antonia M. Calafat, Gina Muckle, Bruce P. Lanphear, Aimin Chen
Summary: Prenatal PFOS and PFNA were consistently associated with measures related to hyperactive impulsive type ADHD across two validated assessment instruments. PFHxS was associated with increased problems with both externalizing and internalizing behaviors. No associations were noted between PFOA and child neurobehavior.
ENVIRONMENTAL RESEARCH
(2021)
Article
Engineering, Environmental
Zhenyu Chen, Xiaojun Luo, Yuan Zeng, Shufei Tan, Jie Guo, Zhenming Xu
Summary: The study found that the mass concentration of PM10 was higher but the number concentration was lower in the manual dismantling workshop compared to the thermal dismantling workshop. The gaseous phase PBDE concentration was higher in the manual dismantling workshop while the particulate phase PBDE concentration was higher in the thermal dismantling workshop. The size distribution of particles was similar between the two workshops, but there were significant differences in the distribution of particle-bound PBDE.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Jinsong Xue, Qingqing Xiao, Min Zhang, Dan Li, Xiaofei Wang
Summary: Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants found in various materials. They have been detected in soil, air, water, dust, and animal tissues, and are associated with a range of toxic effects on different organ systems. Understanding the mechanisms and potential toxicity of PBDEs is important for developing effective prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yun Huang, Fang Fang, Yan Chen, Xiaoqing He, Qian Chen, Hui Wang, Jun Zhang, Shanghai Birth Cohort
Summary: This study found that prenatal exposure to PFAS may increase the risk of sleep disturbances in infants, including poor sleep quality, breathing difficulties, and night wakings. This suggests that pregnant women should avoid exposure to PFAS to protect the health of their unborn babies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Ming-Jun Hu, Jin-Liang Zhu, Qian Zhang, Jia-Liu He, Wan-Jun Yang, Zhen-Yu Zhu, Jia-Hu Hao, Fen Huang
Summary: Exposure to PBDEs and metals among rural adult residents along the Yangtze River in China may influence thyroid function, with some PBDE congeners and metals showing associations with thyroid hormones. However, there was no statistically significant association observed between PBDEs, metals, and thyroid-stimulating hormone. Bayesian Kernel Machine Regression analysis suggested similar trends in the relationship between PBDEs, metals mixtures, and thyroid hormones. Additional studies are needed to confirm these findings and identify potential mechanisms.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Allison Kupsco, Haotian Wu, Antonia M. Calafat, Marianthi-Anna Kioumourtzoglou, Alejandra Cantoral, Marcela Tamayo-Ortiz, Ivan Pantic, Maria Luisa Pizano-Zarate, Emily Oken, Joseph M. Braun, Andrea L. Deierlein, Robert O. Wright, Martha M. Tellez-Rojo, Andrea A. Baccarelli, Allan C. Just
Summary: Prenatal concentrations of urinary DEHP metabolites, DiNP metabolites, and MCNP were associated with trajectories of child adiposity, while the total phthalate mixture showed no significant association with early life child adiposity.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jordan R. Kuiper, Joseph M. Braun, Antonia M. Calafat, Bruce P. Lanphear, Kim M. Cecil, Aimin Chen, Yingying Xu, Kimberly Yolton, Heidi J. Kalkwarf, Jessie P. Buckley
Summary: Pregnancy phthalate exposures were found to be positively associated with increased bone mineral density Z-scores in early adolescence, with different patterns of associations observed between males and females. Further research is needed to determine the long-term implications for skeletal health.
Article
Environmental Sciences
Paulina Jedynak, Jorg Tost, Antonia M. Calafat, Ekaterina Bourova-Flin, Lucile Broseus, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Joel Schwartz, Remy Slama, Daniel Vaiman, Johanna Lepeule, Claire Philippat
Summary: This study is the first to describe genome-wide modifications of placental DNA methylation in association with pregnancy exposure to phthalates. The results suggest that exposure to phthalates could affect fetal development through epigenetic mechanisms. Several differentially methylated regions associated with phthalate exposure were identified.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Jefferey L. Burgess, Julia M. Fisher, Amy Nematollahi, Alesia M. Jung, Miriam M. Calkins, Judith M. Graber, Casey C. Grant, Shawn C. Beitel, Sally R. Littau, John J. Gulotta, Darin D. Wallentine, R. Jeffrey Hughes, Charles Popp, Antonia M. Calafat, Julianne C. Botelho, Alissa D. Coleman, Natasha Schaefer-Solle, Paola Louzado-Feliciano, Simi O. Oduwole, Alberto J. Caban-Martinez
Summary: This study compared serum PFAS concentrations in firefighters from multiple fire departments with a general population sample. The results showed elevated concentrations of several PFAS in firefighters from four departments.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Environmental Sciences
Samantha Schildroth, Lauren A. Wise, Amelia K. Wesselink, Traci N. Bethea, Victoria Fruh, Kyla W. Taylor, Antonia M. Calafat, Donna D. Baird, Birgit Claus Henn
Summary: This study found that personal care product use, diet, and contraceptive measures may be the main sources of exposure to multiple non-persistent endocrine disrupting chemicals among reproductive-aged Black women.
Article
Peripheral Vascular Disease
Ning Ding, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, Antonia M. Calafat, Sioban D. Harlow, Sung Kyun Park
Summary: The study revealed positive associations between several PFAS and incident hypertension, suggesting that PFAS might be an underappreciated contributing factor to women's cardiovascular disease risk.
Article
Public, Environmental & Occupational Health
Antonio J. Signes-Pastor, Megan E. Romano, Brian Jackson, Joseph M. Braun, Kimberly Yolton, Aimin Chen, Bruce Lanphear, Margaret R. Karagas
Summary: Exposure to arsenic during pregnancy may increase the risk of intellectual deficits in children, especially at low exposure levels. This study found a negative association between prenatal maternal urinary arsenic concentrations and childhood cognitive abilities, with stronger effects observed in children whose mothers had lower iAs methylation capacity and lower urinary arsenobetaine concentrations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Lidia Minguez-Alarcon, Lisa Frueh, Paige L. Williams, Tamarra James-Todd, Irene Souter, Jennifer B. Ford, Kathryn M. Rexrode, Antonia M. Calafat, Russ Hauser, Jorge E. Chavarro
Summary: This study investigates the association between urinary phenol concentrations and serum lipid levels in pregnant women. The results suggest that pregnant women with higher concentrations of urinary propylparaben and bisphenol A have higher levels of total cholesterol, non-HDL cholesterol, and LDL cholesterol in their serum.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pediatrics
Barrett M. Welch, Alexander P. Keil, Jessie P. Buckley, Antonia M. Calafat, Kate E. Christenbury, Stephanie M. Engel, Katie M. O'Brien, Emma M. Rosen, Tamarra James-Todd, Ami R. Zota, Kelly K. Ferguson
Summary: A large study conducted in the US found that phthalate exposure during pregnancy may increase the odds of preterm birth. Reducing the concentration of phthalate metabolites could potentially prevent preterm births.
Editorial Material
Obstetrics & Gynecology
Aimin Chen
FERTILITY AND STERILITY
(2022)
Article
Public, Environmental & Occupational Health
Julie L. Ware, Ruowei Li, Aimin Chen, Jennifer M. Nelson, Jennifer M. Kmet, Sharyn E. Parks, Ardythe L. Morrow, Jian Chen, Cria G. Perrine
Summary: This study analyzed the association between initiation of breastfeeding and post-perinatal infant mortality at the state and regional levels in the United States. The results showed that all seven U.S. geographic regions had significant reductions in postperinatal infant deaths associated with breastfeeding initiation. The Mid-Atlantic and Northeast regions had the largest reductions, while the Southeast had the smallest reduction.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Jordan R. Kuiper, Shudi Pan, Bruce P. Lanphear, Antonia M. Calafat, Aimin Chen, Kim M. Cecil, Yingying Xu, Kimberly Yolton, Heidi J. Kalkwarf, Joseph M. Braun, Jessie P. Buckley
Summary: Background: Early life environmental exposures may affect bone mass accrual in childhood, but only limited research has been done on the role of environmental phenols in child bone health. This study found weak associations between the concentrations of environmental phenols and bone mineral content and density, suggesting the need for further research on the mechanisms of this effect.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Zana Percy, Aimin Chen, Heidi Sucharew, Weili Yang, Ann M. Vuong, Joseph M. Braun, Bruce Lanphear, Maria Ospina, Antonia M. Calafat, Kim M. Cecil, Yingying Xu, Kimberly Yolton
Summary: This study aimed to assess the impact of early-life exposure to an OPE mixture on child behavior. It was found that higher urinary concentrations of OPE metabolites during pregnancy and postnatal period were associated with child behavioral problems at 3 and 8 years, including internalizing, externalizing, and overall negative behaviors. However, there was no consistent pattern in terms of the direction of the effects or a particularly sensitive time point.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Taylor M. Etzel, Jordan R. Kuiper, Xiaobin Wang, Noel T. Mueller, Antonia M. Calafat, Kim M. Cecil, Aimin Chen, Bruce P. Lanphear, Kimberly Yolton, Heidi J. Kalkwarf, Joseph M. Braun, Jessie P. Buckley
Summary: A prospective study found that early-life phthalate exposures may affect cardiometabolic outcomes during adolescence. The concentrations of nine phthalate metabolites in urine samples collected during pregnancy and childhood were associated with cardiometabolic biomarkers at age 12, with differences observed between males and females.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Meeting Abstract
Obstetrics & Gynecology
Barrett M. Welch, Alexander P. Keil, Jessie P. Buckley, Antonia M. Calafat, Kate E. Christenbury, Stephanie M. Engel, Katie M. O'Brien, M. Rosen Rosen, Kelly K. Ferugson
REPRODUCTIVE SCIENCES
(2022)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)