Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Article
Cell & Tissue Engineering
Jin Li, Junru Chen, Xiaoyu Luo, Guangxiu Lu, Ge Lin
Summary: The efficiency of inducing human embryonic stem cells into NEUROG3+ pancreatic endocrine cells is a challenge in stem cell therapy for diabetes. Single-cell transcriptome analysis revealed that the combination of DAPT with four factors (4FS) increased the expression of NEUROG3 to approximately 34.3%, promoting the differentiation of pancreatic endocrine cells. Gene expression analysis suggests potential strategies to enhance the differentiation of INS+GCG+ cell population.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Nutrition & Dietetics
Andreanna Burman, Izumi Kaji
Summary: The small intestine plays a major role in nutrient sensing, with taste receptors responding to specific ligands like carbohydrates, fats, and proteins. Activation of nutrient sensors helps in processing incoming nutrients and defects can lead to metabolic disorders. Recent studies focus on mechanisms related to intestinal nutrient sensors and their roles in disease.
Article
Pathology
Hanine Medani, Mohamed Elshiekh, Kikkeri N. Naresh
Summary: PHH3 immunohistochemistry is found to be a reliable mitosis-specific marker in MCL, making it easier to perform precise counts and evaluate proliferation indices compared to traditional Ki-67 estimation.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Anatomy & Morphology
Nader Goodarzi, Mohsen Akbari Bazm, Sadra Poladi, Fatemeh Rashidi, Bahareh Mahmoudi, Mohamed M. A. Abumandour
Summary: The study investigated the histology, immunohistochemistry, stereology, and ultrastructure of the small intestine in common pheasants using light and scanning electron microscopy. The jejunum was found to be the most prominent region in terms of morphological and morphometric features, suggesting it plays a key role in nutrient absorption.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Biotechnology & Applied Microbiology
Qingyao Zhao, Qinglei Xu, M. A. Serafino, Qin Zhang, Chuduan Wang, Ying Yu
Summary: Diarrhea is a common disease in pig industry, causing significant economic losses and threatening piglet health. This study explored the role of circular RNA (circRNA) in regulating the adhesion of piglet small intestinal epithelial cells to Enterotoxigenic Escherichia coli F4 fimbriae (ETEC-F4). The circRNA expression profiles of piglets with different adhesion phenotypes were analyzed, revealing potential circRNA biomarkers for susceptibility to ETEC diarrhea in piglets.
Article
Agriculture, Dairy & Animal Science
Cristiano Bombardi, Anna Maria Rambaldi, Giorgia Galiazzo, Fiorella Giancola, Jean-Marie Graic, Giulia Salamanca, Bruno Cozzi, Roberto Chiocchetti
Summary: The gastrointestinal tract of bottlenose dolphins differs from that of terrestrial mammals in structure and function, with distinctive distribution of nNOS-IR and SP-IR neurons which may contribute to unique intestinal functions in these special mammals.
Article
Cell Biology
Ladislav Roller, Ivana Daubnerova, Akira Mizoguchi, Honoo Satake, Yoshiaki Tanaka, Matej Stano, Lubos Klucar, Dusan Zitnan
Summary: This study comprehensively mapped the production of different regulatory peptides by enteroendocrine cells (ECs) in the larval midgut of Bombyx mori, revealing the importance of the midgut as a major source of regulatory molecules in insects. The specific roles and functional significance of these peptides are still largely unknown and require further investigation.
CELL AND TISSUE RESEARCH
(2022)
Article
Environmental Sciences
Asok K. Dasmahapatra, Paul B. Tchounwou
Summary: In this study, the effects of graphene oxide (GO) as an endocrine disrupting chemical (EDC) on the endocrine pancreas of Japanese medaka adults were investigated. It was found that GO exposure enhanced immunoreactivity in the islet organs, and the impairments in the pancreas were inconsistent and influenced by exposure routes and sex of the fish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Bahram Sayyaf Dezfuli, Giuseppe Castaldelli, Massimo Lorenzoni, Antonella Carosi, Mykola Ovcharenko, Giampaolo Bosi
Summary: A subpopulation of 97 European eels was obtained from Lake Trasimeno, and they were examined for parasites in the swimbladder and intestine. The swimbladders of 68% of the eels contained adult specimens of the nematode Anguillicoloides crassus, with an average intensity of infection of 7.27 worms per swimbladder. The infected swimbladders showed thickened walls, presence of black-brownish nematodes, and various pathological changes.
Article
Cell Biology
Valeriya V. Zinina, Melanie Sauer, Lira Nigmatullina, Nastasja Kreim, Natalia Soshnikova
Summary: This study investigated the role of TCF7L1 in the embryonic and adult intestinal epithelium using conditional mouse mutants. The results showed that TCF7L1 prevents the precocious differentiation of embryonic intestinal epithelial progenitors towards enterocytes and ISCs. In addition, TCF7L1 is necessary for the differentiation of secretory epithelial progenitors along the tuft cell lineage and for the differentiation of enteroendocrine D- and L-cells in the anterior small intestine. The study concludes that TCF7L1-mediated repression of both Notch and WNT pathways is crucial for the correct differentiation of intestinal secretory progenitors.
Review
Gastroenterology & Hepatology
Shunji Fujimori, Ryohei Hamakubo, Aitoshi Hoshimoto, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Shu Tanaka, Atsushi Tatsuguchi, Katsuhiko Iwakiri
Summary: The frequency of primary small intestinal adenocarcinoma is low, and it mainly occurs in the proximal small intestine. Dietary factors and the influence of intestinal content may contribute to its carcinogenesis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Jiaying Wen, Xueting Niu, Shengwei Chen, Zongzhou Chen, Shuting Wu, Xinchen Wang, Yanhong Yong, Xiaoxi Liu, Zhichao Yu, Xingbin Ma, A. M. Abd El-Aty, Xianghong Ju
Summary: This study investigated the distribution of chitosan oligosaccharide (COS) after oral administration and the changes in protein expression related to innate immune response. The results showed that COS mainly distributed in the stomach, duodenum, and kidney and increased the number of monocytes and lymphocytes in peripheral blood. Proteomic analysis revealed the activation of the intestinal immune network for IgA production pathway. The expression of IgA, MHCII, TGF-131, IL-6, and pIgR were significantly increased after exposure to COS. These findings suggest that COS can enhance intestinal mucosal immunity and may be used as a vaccine or drug adjuvant for small intestinal mucosa.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elias A. T. Koch, Michael Erdmann, Carola Berking, Franklin Kiesewetter, Rafaela Kramer, Stefan Schliep, Markus V. Heppt
Summary: PRAME is a cancer testis antigen that is highly expressed in melanoma. However, the interpretation of PRAME immunostaining is not standardized, making it difficult to interpret. In this study, PRAME-stained histological slides of superficial spreading melanomas (SSM) and dysplastic nevi (DN) were analyzed using a digital pathology platform. A cut-off score of 97.67 cells/mm(2) was defined to distinguish between DN and SSM. The computer-aided assessment of PRAME immunostaining is a useful tool in dermatopathology to differentiate between DN and SSM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Sophie Mueller, Isabel Grote, Stephan Bartels, Leonie Kandt, Henriette Christgen, Ulrich Lehmann, Oleg Gluz, Monika Graeser, Ron Kates, Nadia Harbeck, Hans Kreipe, Matthias Christgen
Summary: This study determined the optimal p53 index cutoff for identifying TP53-mutated breast cancer. The cutoffs were >34.6% for baseline biopsies and >25.3% for post-treatment specimens. These cutoffs can effectively identify mutated breast cancer, and the study has important implications for treatment planning.
Article
Chemistry, Applied
T. J. Puumalainen, A. Puustinen, S. Poikonen, K. Turjanmaa, T. Palosuo, K. Vaali
Article
Immunology
Katariina Nurmi, Ilona Kareinen, Juhani Virkanen, Kristiina Rajamaki, Vesa-Petteri Kouri, Kirsi Vaali, Anna-Liisa Levonen, Nanna Fyhrquist, Sampsa Matikainen, Petri T. Kovanen, Kari K. Eklund
JOURNAL OF INNATE IMMUNITY
(2017)
Article
Immunology
Pirkka T. Pekkarinen, Kirsi Vaali, Sami Junnikkala, Laura H. Rossi, Heli Tuovinen, Seppo Meri, Outi Vaarala, T. Petteri Arstila
Article
Allergy
Pirkka T. Pekkarinen, Kirsi Vaali, Hanna Jarva, Eliisa Kekalainen, Iivo Hetemaki, Sami Junnikkala, Merja Helminen, Outi Vaarala, Seppo Meri, T. Petteri Arstila
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Jussi O. Ropponen, Simo O. Syrjala, Maria Hollmen, Raimo Tuuminen, Rainer Krebs, Mikko A. Keranen, Kirsi Vaali, Antti I. Nykanen, Karl. B. Lemstrom, Jussi M. Tikkanen
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2012)
Article
Gastroenterology & Hepatology
K. Vaali, J. Lappalainen, A. H. Lin, M. I. Mayranpaa, P. T. Kovanen, A. Berstad, K. K. Eklund
NEUROGASTROENTEROLOGY AND MOTILITY
(2012)
Review
Gastroenterology & Hepatology
Gulen Arslan Lied, Kristine Lillestol, Ragna Lind, Jorgen Valeur, Mette Helvik Morken, Kirsi Vaali, Kine Gregersen, Erik Florvaag, Tone Tangen, Arnold Berstad
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2011)
Article
Immunology
L. -Z. Sun, S. Elsayed, T. B. Aasen, T. Van Do, N. P. Aardal, E. Florvaag, K. Vaali
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2010)
Article
Immunology
A. H. Lin, E. Florvaag, T. Van Do, S. G. O. Johansson, A. Levsen, K. Vaali
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2012)
Letter
Immunology
Tamara Tuuminen, Tina Jaaskelainen, Kirsi Vaali, Olli Polo
AUTOIMMUNITY REVIEWS
(2019)
Letter
Public, Environmental & Occupational Health
Tamara Tuuminen, Maria Andersson, Saija Hyvonen, Jouni Lohi, Kirsi Vaali
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2020)
Article
Microbiology
Kirsi Vaali, Marja Tuomela, Marika Mannerstrom, Tuula Heinonen, Tamara Tuuminen
Summary: This study aimed to establish a causal connection between the symptoms experienced by workplace occupants and the presence of toxic dampness microbiota in the building. Through medical examinations and analysis of urine samples, it was found that the presence of mycotoxins in the indoor air was associated with the morbidity of the occupants. Building-derived bacteria and fungi were also identified and found to be toxic. Cytotoxicity tests of indoor air condensates proved to be a promising tool for risk assessment in moisture-damaged buildings.
Article
Microbiology
Kirsi Vaali, Kingsley Mokube Ekumi, Maria A. Andersson, Marika Mannerström, Tuula Heinonen
Summary: Markers were sought to diagnose mold hypersensitivity through indoor air testing and immunoglobulin measurement. The study found that exposed subjects had more symptoms from occupational air than control subjects. Basophil activation tests showed increased sensitivity to toxic extracts from the target building. Fecal immunoglobulin levels correlated with inflammation, confirming mold exposure.
Article
Immunology
Saija M. Hyvonen, Jouni J. Lohi, Leena A. Rasanen, Tuula Heinonen, Marika Mannerstrom, Kirsi Vaali, Tamara Tuuminen
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)