Article
Gastroenterology & Hepatology
Shahana Prakash, Tomohiro Tanaka, Divya Ashat
Summary: Indeterminate colitis (IC) is a subtype of inflammatory bowel disease (IBD) with features of both Crohn's disease (CD) and ulcerative colitis (UC). This study examines the characteristics of patients hospitalized with IC in the United States (US) and compares them with patients admitted with CD and UC. The study also analyzes trends in cost and length of stay.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
R. L. Goetgebuer, C. J. van der Woude, L. Bakker, A. A. van der Eijk, L. de Ridder, A. C. de Vries
Summary: There is a significant practice variation in the diagnosis and management of CMV colitis in IBD among gastroenterologists in the Netherlands. This study highlights the need for pragmatic studies and guidelines to reduce practice variation and improve the quality of care.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kristina Bertl, Johan Burisch, Nikolaos Pandis, Corinna Bruckmann, Bjorn Klinge, Andreas Stavropoulos
Summary: The aim of this questionnaire-based case-control study was to assess whether self-reported oral health and periodontitis differed in patients with ulcerative colitis (UC) and Crohn's disease (CD) compared to matched controls without inflammatory bowel disease (IBD). The study found that patients with UC and CD had significantly worse oral health and more severe periodontal problems compared to controls, with CD patients being more severely affected and losing more teeth. Close surveillance of IBD patients is strongly recommended to prevent periodontitis development and/or mitigate its progression.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Ahmed Almradi, Alexandra C. Istl, Mei Lucy Yang, Katherine A. Fleshner, Claire E. Parker, Leonardo Guizzetti, Christopher Ma, Siddharth Singh, Vipul Jairath
Summary: The study found that preoperative anti-TNF therapy in patients with Crohn's disease undergoing elective surgery was associated with increased odds of postoperative infection, while it did not significantly affect total complications. In patients with ulcerative colitis undergoing elective surgery, preoperative anti-TNF therapy did not show significant associations with either infectious or total complications.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Gastroenterology & Hepatology
Nathaniel A. Cohen, Maryam Zafer, Namrata Setia, Michael J. Anderson, Atsushi Sakuraba, Sushila Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin, Dejan Micic
Summary: This study found that serum CMV PCR can be used as a non-invasive test for diagnosing CMV colitis in UC patients, and it has excellent negative predictive value and a strong correlation with CMV positivity on histology.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Immunology
Canhua Luo, Huangwei Chen, Huihuan Wu, Yongjia Liu, Guoyin Li, Weijian Lun
Summary: This article presents a case of colitis induced by Toripalimab in a patient with advanced nasopharyngeal carcinoma. The patient's symptoms were accompanied by inflammatory manifestations evident in colonoscopy and pathology results, which revealed cytomegalovirus (CMV) infection. Treatment with ganciclovir and steroids resulted in symptom relief and mucosal healing. The findings highlight the association between irColitis caused by Toripalimab and CMV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall, Ajit Sood
Summary: Malnutrition and sarcopenia are common in patients with inflammatory bowel disease (IBD), and the prevalence is similar in patients with ulcerative colitis (UC) and Crohn's disease (CD). Threshold values of different parameters of nutritional assessment can be used to identify malnutrition.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Catherine Verhaeghe, Marja Talikka, Alain Sewer, Nicolas Sierro, Mehdi Auberson, Dariusz Peric, David Bornand, Remi Dulize, Emmanuel Guedj, Patrick Nef, Sebastien P. Tabruyn, Julia Hoeng, Manuel C. Peitsch, Giuseppe Lo Sasso
Summary: This study investigated the potential anti-inflammatory activities of tobacco alkaloids nicotine and anatabine in a fully humanized UC mouse model. The results showed that nicotine significantly reduced acute colitis symptoms and improved colitis-specific endpoints. Anatabine also demonstrated similar effectiveness, although weaker or not significant. Gene expression analysis provided insights into the possible mechanism by which nicotine attenuated DSS-induced colitis in humanized mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Lianne Heuthorst, Aart Mookhoek, Manon E. Wildenberg, Geert R. D'Haens, Willem A. Bemelman, Christianne J. Buskens
Summary: The study found that the histological features of UC appendices resemble UC rather than acute appendicitis, and the presence of active appendiceal inflammation is common in UC patients and does not correlate with colonic disease activity. Over 50% of UC patients in remission showed active histological disease in the appendix, and favorable response to appendectomy for refractory UC cases with ulcerative appendicitis was observed, supporting the role of the appendix as a pivotal organ in UC.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Eun Soo Kim, Sung Kook Kim, Dong Il Park, Hyo Jong Kim, Yoo Jin Lee, Ja Seol Koo, Eun Sun Kim, Hyuk Yoon, Ji Hyun Lee, Ji Won Kim, Sung Jae Shin, Hyung Wook Kim, Hyun-Soo Kim, Young Sook Park, You Sun Kim, Tae Oh Kim, Jun Lee, Chang Hwan Choi, Dong Soo Han, Jaeyoung Chun, Hyun Soo Kim
Summary: This study compared trough infliximab levels and the development of antidrug antibody (ADA) for 1 year between Crohn's disease (CD) and ulcerative colitis (UC) patients who were biologic-naive. The results showed that infliximab had higher trough drug levels and lower ADA levels in CD patients, leading to better clinical outcomes.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Review
Immunology
Susanna Esposito, Giulia Chiopris, Giulia Messina, Tiziana D'Alvano, Serafina Perrone, Nicola Principi
Summary: CMV is a common cause of congenital infection and non-genetic sensorineural hearing loss in children, with up to 2% of neonates affected, particularly in developing countries. Research on a vaccine to prevent CMV infection faces challenges due to the complex relationship between the host's immune system and the virus, highlighting the need for further studies.
