Article
Immunology
Xianqi Peng, Abdelaziz Ed-Dra, Yan Song, Mohammed Elbediwi, Reshma B. Nambiar, Xiao Zhou, Min Yue
Summary: This study investigated the protective effects and mechanisms of Lacticaseibacillus rhamnosus on the intestinal mucosal barrier of chicks infected with Salmonella. The results showed that L. rhamnosus significantly reduced diarrhea, improved gut immunity, and inhibited intestinal inflammation in infected chicks. Pre-treatment with L. rhamnosus balanced the expression of immune factors, regulated endotoxin and D-lactic acid levels, and enhanced the function of intestinal mucosal epithelial cells. Additionally, L. rhamnosus weakened the adhesion of Salmonella and increased intestinal microbiota diversity in infected chicks.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fang Liu, Allen D. Smith, Thomas T. Y. Wang, Quynhchi Pham, Lumei Cheung, Haiyan Yang, Robert W. Li
Summary: In this study, the antimicrobial properties of blueberry anthocyanin malvidin 3-glucoside (MG) were investigated using a multi-omics approach with Citrobacter rodentium. MG supplementation reversed the negative effects of infection, improved colonic hyperplasia and histopathological scores, and restored microbial dysbiosis caused by C. rodentium. MG also mediated several host- and microbiota-derived metabolites and normalized the dysregulated bioactive lipid oleoylethanolamine.
Review
Biochemistry & Molecular Biology
L. Moine, M. M. Canali, C. Porporatto, S. G. Correa
Summary: Chitosan is a versatile polymer with various biomedical applications, and its chemical modification can give rise to numerous derivatives that are suitable for different types of drug formulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Gastroenterology & Hepatology
Yoshinori Hanawa, Masaaki Higashiyama, Chie Kurihara, Rina Tanemoto, Suguru Ito, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Kenichi Inaba, Nao Sugihara, Kazuki Horiuchi, Yoshikiyo Okada, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Ryota Hokari
Summary: Acesulfame potassium induces gut mucosal injury, dysbiosis, and increased immune cell migration, suggesting that the widespread use of non-caloric artificial sweeteners may not be as safe as previously believed.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Weipeng Wang, Ying Wang, Ying Lu, Jing Zhu, Xinbei Tian, Bo Wu, Jun Du, Wei Cai, Yongtao Xiao
Summary: Regenerating islet-derived family member 4 (Reg4) has been found to possess potent bactericidal activity against Salmonella Typhimurium (S. Tm), inhibiting colonization of S. Tm in the intestine and ameliorating intestinal inflammation. Reg4 proteins can restrict Salmonella invasion of intestinal epithelia by binding to the flagella of Salmonella, suppressing bacterial motility and the host inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhongyue Ren, Lingling Peng, Shufang Chen, Yi Pu, Huihui Lv, Hua Wei, Cuixiang Wan
Summary: Salmonella Typhimurium is commonly found in food and can cause infection in the gastrointestinal tract. This study investigated the effect of a high-fat diet (HFD) on S. Typhimurium infection and the potential protective effects of Lactiplantibacillus plantarum 1201 intervention. The results showed that HFD exacerbated the infection, while intervention with L. plantarum 1201 effectively reduced colonization and inflammation. These findings suggest that L. plantarum 1201 may be a potential preventive strategy against S. Typhimurium infection.
Article
Cell Biology
Gaoliang Yuan, Weihua Zhao, Yanwei Zhang, Zhao Jia, Kangyong Chen, Junya Wang, Hao Feng, Jun Zou
Summary: IL-21 is induced in grass carp leukocytes and tissues in response to bacterial infection. It promotes the expression of antibacterial genes and inhibits the NF-kappa B signaling pathway. IL-21 is expressed in CD3γ/δT cells and accumulates in the intestine, indicating its important role in regulating intestinal inflammation induced by bacterial infection in grass carp.
Article
Biochemistry & Molecular Biology
Wenshu Zou, Jingyan Zhang, Kai Zhang, Zhiping Peng, Ruihua Xin, Lei Wang, Jianxi Li
Summary: This study found that Asiatic acid (AA) can attenuate microglial inflammation induced by Salmonella typhimurium (S.T). AA upregulated the expression of lncRNA TVX1, leading to the suppression of pro-inflammatory factors and inhibition of the NF-κB pathway and NLRP3 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Dadi Falay, Liselotte Hardy, Edmonde Bonebe, Wesley Mattheus, Dauly Ngbonda, Octavie Lunguya, Jan Jacobs
Summary: This study found evidence of household clustering of Salmonella Typhimurium ST313 and intestinal carriage of iNTS several weeks after bloodstream infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolas Barnich, Michael Rodrigues, Pierre Sauvanet, Caroline Chevarin, Sylvain Denis, Olivier Le Goff, Danielle Faure-Imbert, Thierry Hanh, Christian F. Roques, Benoit Chassaing, Monique Alric
Summary: The study demonstrates that two French natural mineral waters (NMWs) exhibit anti-inflammatory effects in intestinal epithelial cells, with one of them effectively reducing intestinal inflammation, disease activity score, fecal lipocalin-2 levels, and pro-inflammatory cytokine release in induced-colitis mice, while also preventing alterations in mucosa-associated microbiota. These findings highlight the potential clinical efficiency of such NMWs in contributing to a lower state of inflammation in inflammatory bowel disease in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Hang Zhang, Minjuan Wang, Junpeng Jia, Jiayi Zhao, Stoffel Matjeke Radebe, Qinghua Yu
Summary: This study demonstrated the effectiveness of Enterococcus faecium YQH2 in preventing Salmonella typhimurium infection in chickens, showcasing its potential protective mechanism and future applications in chicken health breeding.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Food Science & Technology
Pilar Rodriguez-Viso, Adrian Domene, Dinoraz Velez, Vicenta Devesa, Manuel Zuniga, Vicente Monedero
Summary: A bicameral model consisting of intestinal epithelial cells (Caco-2 and HT29-MTX) and macrophages (THP-1-derived) was used to study the protective effects of two strains of Lactobacillus against mercury-induced damage. Exposure to mercury for seven days resulted in inflammation, oxidative stress, impaired intestinal barrier, and reduced wound healing capacity. However, the presence of heat-killed Lactobacillus cells during mercury exposure reversed these effects. The binding of mercury by the lactobacilli suggests a mechanism of sequestration that counteracted mercury toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Cell Biology
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martinez-Sanchez, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Rho proteins are crucial regulators of the cytoskeleton, cell morphology, and trafficking. Their function is determined by GTP/GDP exchange and prenylation, allowing binding to cell membranes and interaction with downstream effector proteins. In the context of the GI tract, Rho GTPases play important roles in maintaining tissue homeostasis.
Article
Microbiology
Ayesha Lone, Walid Mottawea, Yasmina Ait Chait, Riadh Hammami
Summary: The poultry industry is rapidly growing, but safety concerns and the need for antibiotic alternatives are important. Salmonella and Clostridium perfringens are common pathogens, prompting the search for potential probiotics. Isolated strains showed inhibitory activity against major pathogens, with some exhibiting probiotic characteristics.
Review
Biochemistry & Molecular Biology
Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-jun Yang, Fei-fei Wang, Hong-wei Shang, Rongxuan Hua, Jing-dong Xu
Summary: This article summarizes the functions of IL-6 in maintaining intestinal homeostasis, explores its relation with the nervous system, and highlights its potential role in Parkinson's disease. It also points out the dual-sided influence of IL-6 on intestinal tumors and inflammation, and how they are achieved through different processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Lianne M. S. Bouwman, Jose M. S. Fernandez-Calleja, Hans J. M. Swarts, Inge van der Stelt, Annemarie Oosting, Jaap Keijer, Evert M. van Schothorst
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Pediatrics
David C. A. Candy, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Harm Wopereis, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, Adam T. Fox, Neil Shah, Christina E. West, Johan Garssen, Lucien F. Harthoorn, Jan Knol, Louise J. Michaelis
PEDIATRIC RESEARCH
(2018)
Article
Agriculture, Dairy & Animal Science
N. G. J. Costermans, K. J. Teerds, J. Keijer, E. F. Knol, R. E. Koopmanschap, B. Kemp, N. M. Soede
Review
Nutrition & Dietetics
Jasmijn Y. de Vries, Shikha Pundir, Elizabeth Mckenzie, Jaap Keijer, Martin Kussmann
Review
Biochemistry & Molecular Biology
Miranda van der Ende, Sander Grefte, Rogier Plas, Jocelijn Meijerink, Renger F. Witkamp, Jaap Keijer, Klaske van Norren
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2018)
Letter
Allergy
Marlou L. A. de Kroon, Marijn J. Warners, Marleen T. J. van Ampting, Lucien F. Harthoorn, Arjan J. Bredenoord, Mylene van Doorn, Melanie Kok, Bram D. van Rhijn, Simone R. B. M. Eussen, Berber J. Vlieg-Boerstra
Article
Biochemistry & Molecular Biology
Eveline Gart, Everton Souto Lima, Frank Schuren, Christa G. F. de Ruiter, Joline Attema, Lars Verschuren, Jaap Keijer, Kanita Salic, Martine C. Morrison, Robert Kleemann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nutrition & Dietetics
Jose M. S. Fernandez-Calleja, Lianne M. S. Bouwman, Hans J. M. Swarts, Annemarie Oosting, Jaap Keijer, Evert M. van Schothorst
Article
Allergy
Adam T. Fox, Harm Wopereis, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, David C. A. Candy, Neil Shah, Christina E. West, Johan Garssen, Lucien F. Harthoorn, Jan Knol, Louise J. Michaelis, Francoise Smets, Sandra Mullier, Lee Noimark, Antonella Muraro
CLINICAL AND TRANSLATIONAL ALLERGY
(2019)
Article
Microbiology
Janetta Top, Antoni P. A. Hendrickx, Marleen T. J. van Ampting, Kees van Limpt, Jan Knol, Denise van de Kamer, Johanna C. Braat, Marco Viveen, Malbert R. Rogers, Hans Kemperman, Rob J. L. Willems, Fernanda L. Paganelli
Article
Allergy
Mirelle T. A. Kleuskens, Maria L. Haasnoot, Bart M. Herpers, Marleen T. J. van Ampting, Albert J. Bredenoord, Johan Garssen, Frank A. Redegeld, Betty C. A. M. van Esch
Summary: The study investigated the effects of SCFAs acetate, propionate, and butyrate on the esophageal barrier function in EoE, finding that butyrate and propionate can restore the barrier function of esophageal epithelial cells after inflammatory insult. This suggests that these nutraceuticals may have therapeutic benefits in managing EoE.
Article
Allergy
Pantipa Chatchatee, Anna Nowak-Wegrzyn, Lars Lange, Suwat Benjaponpitak, Kok Wee Chong, Pasuree Sangsupawanich, Marleen T. J. van Ampting, Manon M. Oude Nijhuis, Lucien F. Harthoorn, Jane E. Langford, Jan Knol, Karen Knipping, Johan Garssen, Valerie Trendelenburg, Robert Pesek, Carla M. Davis, Antonella Muraro, Mich Erlewyn-Lajeunesse, Adam T. Fox, Louise J. Michaelis, Kirsten Beyer
Summary: This study evaluated tolerance development and safety of an amino acid-based formula including synbiotics in infants with cow's milk allergy. The results showed no difference in cow's milk tolerance between the two groups after 12 and 24 months, and fewer subjects receiving the formula with synbiotics required hospitalization due to infections during the intervention.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Willemijn E. de Rooij, Berber Vlieg-Boerstra, Marijn J. Warners, Marleen T. J. Van Ampting, Betty C. A. M. van Esch, Simone R. B. M. Eussen, Albert J. Bredenoord
Summary: This study aimed to evaluate whether the addition of amino acid-based formula (AAF) to a four-food elimination diet (FFED) is more effective than FFED alone in reducing eosinophilic esophagitis (EoE) and improving quality of life in adult patients. The results showed that while there was no significant difference in eosinophil counts between the two groups after 6 weeks, the group receiving FFED + AAF had a significant improvement in quality of life scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Willemijn E. de Rooij, Mara A. P. Diks, Marijn J. Warners, Marleen T. J. Van Ampting, Betty C. A. M. van Esch, Albert J. Bredenoord
Summary: This study aimed to evaluate the effect of elimination diets on EoE patients. The results showed that elimination diets could reduce symptoms, endoscopic signs, and eosinophil counts. Furthermore, elimination diets were associated with a broad transcriptional response in the esophageal epithelium.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Letter
Allergy
Maria L. L. Haasnoot, Mirelle T. A. Kleuskens, Alejandro Lopez-Rincon, Mara A. P. Diks, Ingrid Terreehorst, Jaap H. H. Akkerdaas, Ronald van Ree, Marleen T. J. van Ampting, Johan Garssen, Frank A. A. Redegeld, Betty C. A. M. van Esch, Albert J. J. Bredenoord
