期刊
DIGESTIVE DISEASES AND SCIENCES
卷 55, 期 2, 页码 253-260出版社
SPRINGER
DOI: 10.1007/s10620-009-0730-7
关键词
Fibrocytes; CD45; Collagen type I; Myofibroblasts; DSS colitis; Wound healing
Fibrocytes contribute to wound healing and are uniquely defined by coexpression of hematopoietic and mesenchymal cell markers. In this study, trafficking of fibrocytes was determined in a murine model of colitis induced by administering 3% dextran sodium sulfate (DSS) for seven days. Colonic tissues were immunostained for CD45, collagen type I (Col I), and alpha-SMA. On day 0, there were no CD45(+) Col I+ cells in colonic tissues. However, on day 7 when inflammatory cells showed remarkable accumulation, oval-shaped CD45(+) Col I+ fibrocytes were obvious in the submucosal layer. On day 14 when colonic tissues were in the healing phase, numerous spindle-shaped CD45(+) Col I+ fibrocytes were observed. Emergence of CD45(+) Col I+ fibrocytes preceded the appearance of alpha-SMA(+) myofibroblasts. Oval-shaped fibrocytes recruited as early as the inflammatory phase of colitis are likely to differentiate into spindle-shaped fibrocytes in the healing phase, suggesting that fibrocytes may promote wound healing in inflamed colonic tissues.
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