Review
Gastroenterology & Hepatology
Roberta Figueiroa Souza, Marcos Antonio Ferreira Caetano, Henrique Inhauser Riceti Magalhaes, Patricia Castelucci
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) are types of Inflammatory Bowel Diseases (IBD) characterized by bowel necrosis and the involvement of enteric neurons and glial cells. The main inflammatory mediator is tumor necrosis factor-alpha (TNF-alpha), which is also associated with the production of other cytokines like interleukins (IL). TNF-alpha acts through two receptors, TNFR1 and TNFR2, which have been detected in IBD and their expression correlates with disease activity. Biologic agents targeting TNF-alpha have revolutionized IBD treatment by inducing and maintaining disease remission in a majority of patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Boonyarut Ladda, Chittapon Jantararussamee, Wisuit Pradidarcheep, Anongnard Kasorn, Udomlak Matsathit, Malai Taweechotipatr
Summary: This study examined the properties of three probiotic strains in colorectal adenocarcinoma cells. It was found that the probiotic L. paracasei strain MSMC39-1 significantly suppressed TNF-a secretion in the cells. Further experiments showed that this strain reduced liver enzyme levels, inhibited TNF-a secretion in colon and liver tissues, alleviated colon and liver histopathology, and increased beneficial bacteria in the gut.
Review
Medicine, General & Internal
Jo L. W. Lambert, Sofie De Schepper, Reinhart Speeckaert
Summary: Biologics used in the treatment of Crohn's disease and ulcerative colitis can lead to various skin eruptions, especially those targeting TNF-alpha and Th17 pathway. It is important to recognize and adapt the treatment strategy accordingly to manage these adverse reactions effectively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Anastasia Mala, Kalliopi Foteinogiannopoulou, Ioannis E. Koutroubakis
Summary: Malignancies are the second leading cause of death in patients with inflammatory bowel diseases (IBD), with the risk of colorectal cancer decreasing over time while the incidence of extraintestinal cancers (EICs) is increasing. This could be due to systemic inflammation or long-lasting immunosuppression. Proper surveillance is crucial for early diagnosis and better prognosis in IBD patients.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
K. J. O'Brien, X. Parisi, N. R. Shelman, M. A. Merideth, W. J. Introne, T. Heller, W. A. Gahl, M. C. V. Malicdan, B. R. Gochuico
Summary: This study aimed to expand the understanding of IBD in patients with Hermsnky-Pudlak syndrome (HPS) by retrospectively analyzing records and clinical features of patients evaluated at the NIH Clinical Center. Results showed that some patients with HPS develop IBD resembling Crohn's disease, with genetic heterogeneity being a feature of HPS IBD. The study also identified HPS3 as a new gene associated with human IBD, and early-onset IBD can occur in patients with HPS.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Geert R. D'Haens, Sander van Deventer
Summary: Anti-TNF antibodies have been used for 25 years, playing a crucial role in Crohn's disease treatment. Many questions about this treatment have been answered through long-term clinical use, and the past experiences have laid the foundation for the development of future therapies.
Article
Medicine, General & Internal
Shirley Cohen-Mekelburg, Beth I. Wallace, Tony Van, Wyndy L. Wiitala, Shail M. Govani, Jennifer Burns, Rachel Lipson, Huifeng Yun, Jason Hou, James D. Lewis, Jason A. Dominitz, Akbar K. Waljee
Summary: This study in a national cohort of veterans examined the association between the use of anti-TNF or corticosteroids and all-cause mortality in patients with IBD. Results suggest that anti-TNF therapy may be linked to reduced mortality compared with prolonged corticosteroid use, particularly among patients with Crohn disease.
Review
Medicine, Research & Experimental
Zelin Feng, Guangbo Kang, Jiewen Wang, Xingjie Gao, Xiaoli Wang, Yulin Ye, Limin Liu, Jingwen Zhao, Xinjuan Liu, He Huang, Xiaocang Cao
Summary: Emerging biologics and small-molecule drugs have changed the treatment landscape of inflammatory bowel disease (IBD), but dual-targeted therapy (DTT) shows promise in overcoming treatment limitations. However, limited data on efficacy, safety, and mechanisms of DTT for Crohn's disease and ulcerative colitis exist. This review summarizes current data on novel targeted drugs for refractory IBD, categorizes therapeutic agents based on targets, and proposes mechanisms of DTT to aid clinical decision-making and future drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Yu Kyung Jun, Joo Young Park, Seong-Joon Koh, Hyunsun Park, Hyoun Woo Kang, Jong Pil Im, Joo Sung Kim
Summary: According to our study, anti-TNF treatment does not contribute to the development of psoriasis in patients with IBD. Based on this, we believe that anti-TNF agents can be used for IBD treatment without concern for psoriasis development.
Article
Biochemistry & Molecular Biology
Xiaoyan Miao, Ren Mao, Yujia You, Huichao Zhou, Chen Qiu, Xuehua Li, Zhihui Chen, Jie Ren, Minhu Chen, Ping Wang, Rongqin Zheng, Tinghui Yin
Summary: This study proposed a method for quantitative assessment of mTNF-alpha expression in the intestinal mucosa using intracolic ultrasound molecular imaging with TNF-alpha-targeted microbubbles. The results showed a significant correlation between the targeted ultrasound signal intensity and inflammatory lesions, indicating the potential use of this technique in personalized medicine for IBD patients.
MOLECULAR MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Perttu Arkkila, Alessandro Armuzzi, Silvio Danese, Jordi Guardiola, Jorgen Jahnsen, Charles Lees, Edouard Louis, Milan Lukas, Walter Reinisch, Xavier Roblin, Minyoung Jang, Han Geul Byun, Dong-Hyeon Kim, Sung Jeong Lee, Raja Atreya
Summary: This study compared the efficacy and safety of infliximab and vedolizumab in adult patients with moderate-to-severe Crohn's disease or ulcerative colitis. The results showed that infliximab had better efficacy during the induction phase and comparable efficacy during the maintenance phase compared to vedolizumab. In terms of safety, there were no significant differences between the two treatments.
BMC GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Gabrio Bassotti, Alessandro Fruganti, Fabrizio Stracci, Pierfrancesco Marconi, Katia Fettucciari
Summary: Clostridioides difficile (C. difficile) is increasingly colonizing humans and animals living with humans, with hypervirulent strains and mutated toxins. Subjects with inflammatory bowel disease (IBD) are more susceptible to C. difficile infection and relapse due to the cytotoxic synergism between C. difficile toxins and proinflammatory cytokines. In IBD subjects, the inflammatory state in the colon increases the susceptibility to C. difficile infection, enhances the cytotoxic activity of toxins, and induces a greater expression of receptors for toxins that lead to cell death by necrosis. Current therapeutic approaches involve monitoring of C. difficile colonization and reducing proinflammatory cytokine levels, with future perspectives including targeted therapy using bacteriophages.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Article
Hematology
Tiantian Chu, Shuhong Hu, Jiaqian Qi, Xueqian Li, Xiang Zhang, Yaqiong Tang, Meng Yang, Yang Xu, Chang-Geng Ruan, Yue Han, De-Pei Wu
Summary: This study investigated the effects of TNF alpha on megakaryocyte and platelet generation and found that TNF alpha had differential effects on their production at different concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Food Science & Technology
Jong Yeon Park, Bich Hang Do, Ju-Seung Lee, Hyun Cheol Yang, Anh Ngoc Nguyen, Martin Krupa, Chong Jai Kim, Yeon Jin Jang, Han Choe
Summary: The study found that recombinant crotamine has significant antinociceptive and anti-inflammatory effects, which are not related to the opioid receptor. Additionally, the effects of intraperitoneal or intraplantar recombinant crotamine are related to TNF-alpha.
Article
Pharmacology & Pharmacy
Faiza Mumtaz, Asma Rashki, Muhammad Imran Khan, Amir Shadboorestan, Alireza Abdollahi, Mahmoud Ghazi-Khansari, Ghallab Alotaibi, Ahmad Reza Dehpour
Summary: This study showed the interaction of sumatriptan with the NMDA/NO and CREB signaling pathways in PTZ-induced seizures, indicating its anticonvulsant effects.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maryam Shekari, Narges Khalilian Gortany, Mina Khalilzadeh, Alireza Abdollahi, Homanaz Ghafari, Ahmad Reza Dehpour, Mahmoud Ghazi-Khansari
Summary: This study demonstrates that pre-treatment with sodium thiosulfate (STS) has protective effects against doxorubicin (DOX)-induced cardiomyopathy. STS improves body weight, electrocardiography parameters, and papillary muscle contractility, while suppressing oxidative stress induced by DOX.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Surgery
Armin Aryannejad, Faezeh Eslami, Maryam Shayan, Nafise Noroozi, Keshvad Hedayatyanfard, Seyed Mohammad Tavangar, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: This study aimed to evaluate the efficacy of CBD on random-pattern skin flap survival in rats and explore the involvement of CB2 receptors. The results showed that pretreatment with CBD significantly improved flap survival in rats and exerted desirable anti-inflammatory effects, possibly mediated by CB2 receptors.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Mokhtari, Neda Sistani Karampour, Mohammad-Hossein Shams, Ahmad Reza Dehpour, Amin Hasanvand
Summary: Progesterone has anti-inflammatory and antioxidative effects and protects against diabetic neuropathy. Treatment with progesterone reduces neuropathic sensitivity, inflammation, and edema, while improving nerve conduction velocity and reducing oxidative stress and inflammatory factors.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Ramin Goudarzi, Golnaz Zamanian, Zahra Seyyedian, Partow Mirzaee Saffari, Ahmad Reza Dehpour, Alireza Partoazar
Summary: This study evaluated the anti-inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in improving poststroke complications like depression in a mice model. The results showed that arthrocen had significant antidepressant-like effects and reduced the production of proinflammatory cytokines in the ischemic brain hippocampus. Moreover, arthrocen increased the number of viable neurons in the stroke mice. These findings suggest that arthrocen has potential as a treatment for poststroke depression by reducing inflammation and protecting neural cells.
FOOD SCIENCE & NUTRITION
(2023)
Article
Behavioral Sciences
Mohammad Amin Sadeghi, Sara Hemmati, Hasan Yousefi-Manesh, Saba Fekrvand, Laleh Foroutani, Ehsan Nassireslami, Mojtaba Yousefi Zoshk, Yasaman Hosseini, Ahmad Reza Dehpour, Mohsen Chamanara
Summary: Combining subchronic fluoxetine with selective nNOS inhibitor 7-nitroindazole accelerated the efficacy of fluoxetine in treating post-traumatic stress disorder, and hippocampal activity showed biphasic correlation with anxiety-related behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sina Jourian, Mohammad Rahimi, Mohammad Amin Manavi, Mohammad-Taha Pahlevan-Fallahy, Razieh Mohammad Jafari, Ali Amini, Ahmad Reza Dehpour
Summary: This study found that ivermectin has an anticonvulsant effect on clonic seizure threshold. Furthermore, the anticonvulsant effect of ivermectin may be mediated through the interaction of the opioidergic system and the nitric oxide pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Maryam Shayan, Faezeh Eslami, Ayda Khosravi, Amir Rashidian, Razie Mohammad Jafari, Seyed Farzad Maroufi, Hasti Tashak Golroudbari, Ahmad Reza Dehpour
Summary: This study found that cyclosporine, ondansetron, and tropisetron have neuroprotective effects against optic nerve crush injury in rats, possibly through the suppression of apoptosis and modulation of calcineurin activity directly and via 5-HT3 receptors.
Article
Pharmacology & Pharmacy
Aysa Ostovaneh, Faezeh Eslami, Nastaran Rahimi, Pegah Dejban, Hamed Shafaroodi, Ata Abbasi, Shirin Shahsavarhaghighi, Ahmad Reza Dehpour
Summary: This study investigated the beneficial effect of sumatriptan in rats with gastric ulcer by stimulating 5HT(1B/1D) receptors and suppressing pro-inflammatory cytokines. Sumatriptan significantly improved gastric injury induced by different ulcer models, suggesting its gastroprotective effects through the involvement of 5HT(1B/1D) receptors.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Mohammad Sheibani, Seyed Mohammad Tavangar, Sara Hemmati, Mohammad Amin Sadeghi, Hassan Akbarniakhaky, Zohreh Mohammadi, Laleh Foroutani, Ahmad Reza Dehpour
Summary: English summary: The study investigates the effects of spermidine on oxidative stress markers and pain threshold in a rat model of chronic constriction injury. The findings suggest that spermidine treatment can alleviate neuropathic pain by reducing oxidative stress and improving pathological changes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour
Summary: Itching is an unpleasant sensation on the skin that affects the quality of life. Bromhexine, derived from Adhatoda vasica, has been found to alleviate acute itch by inhibiting TMPRSS2 and reducing KP activation. Administering 1-Methyl Tryptophan, an IDO inhibitor, also reduces itching. The combined use of bromhexine and 1-MT results in synergistic antipruritic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
Summary: In this study, it was found that sumatriptan has protective effects against mesenteric ischemia and the inhibition of the kynurenine pathway may be involved in this process. Therefore, sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.
PHARMACOLOGICAL REPORTS
(2023)
Review
Surgery
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: The incorporation of skin flaps in wound closure management has shown promise in achieving desirable cosmetic outcomes. However, skin flaps are prone to complications, such as ischemia-reperfusion injury (IRI), due to various factors. Numerous approaches have been attempted to enhance skin flap survival, including pre/post-conditioning with surgical and pharmacological methods. These approaches utilize cellular and molecular mechanisms to reduce inflammation, promote angiogenesis, induce apoptosis and autophagy. The emerging role of stem cells in improving skin flap viability has led to the development of more translational methods. This review aims to provide current evidence on these approaches.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Medicine, General & Internal
Arash Amanlou, Ehsan Nassireslami, Ahmad Reza Dehpour, Amir Rashidian, Mohsen Chamanara
Summary: Seizures and epilepsy have a severe impact on the quality of life for those affected. This review examines the effect of statins on the prevention and treatment of seizures and epilepsy using both animal models and human studies. It discusses the mechanisms of action, side effects, and comparison of different types of statins in relation to seizures. This review provides valuable insights for researchers to clarify the beneficial effects of statins on neurological disorders.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mahla Masoumi, Mohammad Amin Manavi, Razieh Mohammad Jafari, Alireza Mirzaei, Keshvad Hedayatyanfard, Mohammad Taghi Beigmohammadi, Ahmad Reza Dehpour
Summary: This study investigated the anticonvulsant effects of CBD on lithium-pilocarpine-induced SE in rats and found a possible involvement of CB1 receptors and anti-inflammatory effects. The results suggest that CBD may have therapeutic potential for SE, independent of CB2 and GABA(A) receptors.
CANNABIS AND CANNABINOID RESEARCH
(2023)
