Article
Environmental Sciences
Roberto Chiarelli, Chiara Martino, Maria Carmela Roccheri, Fabiana Geraci
Summary: Metal pharmaceutical residues are emerging toxic pollutants in aquatic environments. Vanadium derivatives have potential therapeutic effects in diseases but their impact on aquatic environments is not well-known. This study found that vanadium affected fertilization and caused morphological abnormalities in sea urchin embryos, and it also influenced the proteolytic activity of gelatinases.
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Roberto Chiarelli, Chiara Martino, Rosaria Scudiero, Fabiana Geraci
Summary: This study investigated the effects of vanadium on sea urchin embryo development and proteolytic activity of gelatinases. The results showed that vanadium exposure caused morphological aberrations, reduced embryonic cell distribution, and altered embryo volume. Additionally, vanadium affected the expression and activity of gelatinases, particularly MMP-14. These findings suggest that an integrated approach combining morphology, proteolytic activity, and MMP-14 expression is important for studying the effects of vanadium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cristiane Mayumi Inagati, Debora Lopes Salles Scheffel, Giovana Anovazzi, Juliana Rosa Luiz Alonso, Marcelly Tupan Christoffoli, David Henry Pashley, Carlos Alberto De Souza Costa, Josimeri Hebling
Summary: This study compared the proteolytic activity and degradation rate of human and bovine dentin matrices, finding differences in some aspects but no statistical difference after long-term incubation.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Surgery
Milos Sladojevic, Igor Koncar, Petar Zlatanovic, Zeljka Stanojevic, David Matejevic, Sasenka Vidicevic Novakovic, Jelena Tasic, Perica Mutavdzic, Ivan Tomic, Aleksandra Isakovic, Lazar Davidovic
Summary: The study found a significant correlation between ILT volume and the largest AAA diameter, but no statistical significance in relation to proteolytic activity and protein content of the vascular wall. However, a positive correlation was found between ILT and catalase activity in the AAA wall. Future studies are needed to investigate the impact of ILT on aneurysm progression.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rana Alkattan, Reem Ajaj, Garrit Koller, Subir Banerji, Sanjukta Deb
Summary: The study developed and evaluated a two-step SE system using a functional monomer BMEP, which exhibited satisfactory bond strengths with both enamel and dentine, potentially eliminating the need for selective enamel etching. The addition of BMEP in the primer resulted in higher enamel surface roughness, while BMEP-free adhesives showed similar or higher dentin bond strengths and lower nanoleakage compared to CFSE.
JOURNAL OF DENTISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maristela Barbosa Portela, Caroliny Mello Barboza, Eduardo Moreira da Silva, Daniel Clemente de Moraes, Renata Antoun Simao, Clara Ribeiro de Souza, Veronica da Silva Cardoso, Antonio Ferreira-Pereira, Alane Beatriz Vermelho, Claudiu T. Supuran
Summary: Pre-treatment of dentine with sulphonamide carbonic anhydrase inhibitors (CAIs) maintains stable resin-dentine bond strength, improves dentine wettability, and exhibits antibacterial activity.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Raquel M. Goncalves, Taryn Saggese, Zhiyao Yong, Joana R. Ferreira, Anita Ignatius, Hans-Joachim Wilke, Cornelia Neidlinger-Wilke, Graciosa Q. Teixeira
Summary: This study investigated the impact of the MSC secretome on human annulus fibrosus cells exposed to mechanical loading and a pro-inflammatory environment. The results showed that the inflammatory milieu had a stronger impact on the cells than physiological mechanical stress. The MSC secretome decreased the production of certain proteases in the cells and increased the production of TIMP-1.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Shuo Yin, Aipeng Chen, Xiaoni Fang, Peng Zhang, Chaoyong Yang
Summary: This article introduces a method for simultaneous detection of MMP14 expression and MMP14 proteolytic activity using a fluorescent nanosensor based on a spherical aptamer/peptide dual-probe strategy. The proposed sensor outperforms traditional methods in terms of analytical performances, and has successfully been applied for the detection of exosomal MMP14 from cell culture media and real serum samples. The increased levels of MMP14 expression and proteolytic activity in serum from cancer patients indicate the potential of this method as biomarkers in liquid biopsy for disease diagnosis and real-time surveillance.
Article
Cardiac & Cardiovascular Systems
Alexander E. Kostyunin, Tatiana V. Glushkova, Arseniy A. Lobov, Evgeny A. Ovcharenko, Bozhana R. Zainullina, Leo A. Bogdanov, Daria K. Shishkova, Victoria E. Markova, Maksim A. Asanov, Rinat A. Mukhamadiyarov, Elena A. Velikanova, Tatiana N. Akentyeva, Maria A. Rezvova, Alexander N. Stasev, Alexey V. Evtushenko, Leonid S. Barbarash, Anton G. Kutikhin
Summary: This study aimed to investigate the reasons behind the development of structural valve degeneration (SVD) in ethylene glycol diglycidyl ether-treated bioprosthetic heart valves (BHV). The study found that dysfunctional BHVs suffered from complement-driven neutrophil invasion, excessive proteolysis, unwanted coagulation, and lipid deposition. Neutrophil- and plasma-derived proteases were responsible for the loss of BHV mechanical competence, leading to SVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Biochemistry & Molecular Biology
Didem Keles, Murat Sipahi, Seniz Inanc-Surer, Mustafa B. A. Djamgoz, Gulgun Oktay
Summary: Tetracaine, a type of long-acting amino ester local anesthetic, can inhibit the invasive characteristics of breast cancer cells by suppressing their migratory, invasive, and adhesive abilities. This effect may be achieved by reducing the expression and activity of MMP-2 and MMP-9, as well as increasing TIMP-2 expression. The anti-invasive effects of tetracaine make it a potential candidate for clinical use in surgery and combination therapies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Medicinal
Damiano Rocchi, Cristina Blazquez-Barbadillo, Mariangela Agamennone, Antonio Laghezza, Paolo Tortorella, David Vicente-Zurdo, Noelia Rosales-Conrado, Paula Moyano, Javier del Pino, Juan F. Gonzalez, J. Carlos Menendez
Summary: Matrix metalloproteinases (MMPs) play a key role in neuroinflammatory events and brain damage associated with stroke. The study revealed a new compound with inhibitory effects on MMPs and potential neuroprotective activity against oxidative stress, providing a promising lead for future drug development. The compounds showed some selectivity for specific MMP enzymes and a noncompetitive inhibition mechanism was observed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
