Review
Oncology
Jialun Wang, Yu Chen, Xihan Li, Xiaoping Zou
Summary: Perineural invasion is a complex process that occurs in many malignant tumors, including gastric carcinoma, biliary tract tumor, and pancreatic cancer. It is associated with poor survival and decreased quality of life in pancreatic cancer patients. Studies have revealed subtle molecule regulatory mechanisms during perineural invasion and its potential causal link with pancreatic cancer-associated pain.
Article
Medicine, General & Internal
Hyun-Il Shin, Joo-In Bang, Geun-Jeon Kim, Dong-Il Sun, Sang-Yeon Kim
Summary: This retrospective study aimed to investigate the effect of perineural invasion (PNI) on the prognosis of laryngeal cancer. The results showed that PNI is an independent predictor for poor survival and local recurrence in patients with fresh or salvaged larynges.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Shiqin Liu, Michelle Shen, En-Chi Hsu, Chiyuan Amy Zhang, Fernando Garcia-Marques, Rosalie Nolley, Kashyap Koul, Meghan A. Rice, Merve Aslan, Sharon J. Pitteri, Charlie Massie, Anne George, James D. Brooks, Vincent J. Gnanapragasam, Tanya Stoyanova
Summary: Distinguishing clinically significant from indolent prostate cancer is a major challenge. Using targeted protein biomarker discovery, a novel biomarker PTN for pro-metastatic PC was identified. Elevated serum and tissue PTN levels were associated with poor prognosis and metastatic progression in low- and intermediate-grade disease, indicating its potential for further investigation.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Dandong Luo, Yue-e Wen, Huaxian Chen, Zijian Deng, Jiabo Zheng, Shi Chen, Junsheng Peng, Lei Lian
Summary: This study found that the presence of perineural invasion (PNI) is associated with worse survival in patients with stage II gastric cancer undergoing curative resection. Additionally, adjuvant chemotherapy (AC) was shown to be an independent protective factor for improving survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Hao Wang, Ruixue Huo, Kexin He, Li Cheng, Shan Zhang, Minhao Yu, Wei Zhao, Hui Li, Junli Xue
Summary: In recent years, the importance of the nervous system in the tumor microenvironment has been recognized. The bidirectional communication between nerves and cancer cells is crucial for tumor initiation and progression. Perineural invasion (PNI) is a common feature in various malignancies and is associated with tumor invasion, metastasis, cancer-related pain, and unfavorable clinical outcomes. It is essential to investigate the role of nerves in colorectal cancer (CRC) and understand the mechanisms of PNI in order to impede tumor progression and improve patient survival.
Article
Oncology
Wunai Zhang, Rui He, Wenbin Yang, Yan Zhang, Qinggong Yuan, Jixin Wang, Yang Liu, Shuo Chen, Simei Zhang, Weifan Zhang, Zeen Zhu, Jing Zhang, Zheng Wang, Junhui Li
Summary: Autophagy and perineural invasion (PNI) in pancreatic cancer have negative effects on prognosis. Schwann cells (SCs) in PNI are activated through NGF-mediated autophagy, promoting PNI by enhancing migration and axon guidance towards cancer cells and increasing chemoattraction. Targeting NGF and autophagy for PNI treatment can block nerve infiltration.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
Summary: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in gastric cancer (GC). This study aimed to investigate their prognostic value in curative resected GC patients. The incidence of LVI/PNI was significantly higher in GC patients compared to colorectal cancer patients (50.54% vs. 21.91%, p < 0.001). LVI/PNI was closely associated with disease progression and served as an independent risk factor for lymph node metastasis and overall survival in GC.
Article
Oncology
Tao Qin, Jie Li, Ying Xiao, Xueni Wang, Mengyuan Gong, Qiqi Wang, Zeen Zhu, Simei Zhang, Wunai Zhang, Fang Cao, Liang Han, Zheng Wang, Qingyong Ma, Huanchen Sha
Summary: The study showed that HNK can inhibit the invasion and migration of pancreatic cancer cells, as well as the PNI of pancreatic cancer, partially through inhibition of SMAD2/3 phosphorylation. In vivo, HNK was found to suppress EMT in pancreatic cancer, inhibit cancer cell migration along the nerve, reduce damage to the sciatic nerve caused by tumor cells, and protect the function of the sciatic nerve.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Young Il Kim, Chan Wook Kim, Jong Hoon Kim, Jihun Kim, Jun-Soo Ro, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Summary: In rectal cancer patients who underwent preoperative chemoradiotherapy followed by curative resection, perineural invasion is a reliable independent predictor of recurrence. Patients with perineural invasion should be closely monitored even if they have ypN0 status.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Oncology
Liuyang Bai, Liangying Yan, Yaping Guo, Luyun He, Zhiyan Sun, Wenbo Cao, Jing Lu, Saijun Mo
Summary: The role of perineural invasion (PNI) in esophageal cancer (EC) is significantly related to tumor stage, lymphovascular invasion, lymph node metastasis, 5-year overall survival, and 5-year disease-free survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mei Zhang, Hong-chun Xian, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: Perineural invasion (PNI) is a common clinical feature in malignant tumors that can lead to postoperative recurrence and metastasis. Recent studies have shown that miRNA plays a crucial role in regulating PNI, offering potential new biomarkers and therapeutic targets for cancer treatment.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Jun-Feng Zhang, Ling-Ye Tao, Min-Wei Yang, Da-Peng Xu, Shu-Heng Jiang, Xue-Liang Fu, De-Jun Liu, Yan-Miao Huo, Wei Liu, Jian-Yu Yang, Rong Hua, Ping Lu, Yong-Wei Sun
Summary: The study revealed that the expression level of CD74 in pancreatic ductal adenocarcinoma is an independent predictor of PNI and poor prognosis, with CD74 enhancing migration and invasion capabilities of PDAC by promoting GDNF production to facilitate neuroplasticity in the microenvironment.
Article
Multidisciplinary Sciences
Jihao Tu, Zhehao Huang, Yin Wang, Meijing Wang, Zukun Yin, Xianglin Mei, Meiying Li, Lisha Li
Summary: This study analyzed transcriptome data and constructed co-expression networks to reveal gradually activated gene networks during the progression of pancreatic diseases. The number of differentially expressed genes increases as the pancreatic disease worsens, with upregulation of gene networks involving T cells and interferon.
SCIENTIFIC REPORTS
(2021)
