Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Article
Horticulture
Chao Gong, Huihui Su, Zhenxing Li, Peiting Mai, Baojuan Sun, Zhiliang Li, Zhou Heng, Xiaowan Xu, Songguang Yang, Tao Li
Summary: Our study revealed that histone acetylation mediated by histone deacetylases (HDACs) plays a critical role in the resistance of tomato to bacterial wilt (BW). Most defense-related genes were up-regulated in resistant cultivar, while down-regulated in susceptible cultivar, and silencing of HDACs genes led to a decrease in disease incidence in susceptible cultivar. Under R. solanacearum infection, histone H3 and H4 acetylation levels of defense-related genes were increased, especially in the resistant cultivar.
SCIENTIA HORTICULTURAE
(2021)
Article
Multidisciplinary Sciences
Agnieszka Pierzynska-Mach, Alberto Diaspro, Francesca Cella Zanacchi
Summary: This study used single-molecule localization microscopy (SMLM) to analyze the nanoscale organization of DEK protein. It found differences in cluster features of DEK protein in different breast cell types and showed that the nanoscale organization of DEK clusters remains stable regardless of protein overexpression or chromatin compaction changes.
Article
Cell Biology
Joanna Moronczyk, Agnieszka Braszewska, Barbara Wojcikowska, Karolina Chwialkowska, Katarzyna Nowak, Anna M. Wojcik, Miroslaw Kwasniewski, Malgorzata D. Gaj
Summary: Somatic embryogenesis (SE) is a complex process involving the reprogramming of plant somatic cells, and histone acetylation plays a crucial role in regulating the expression of key transcription factor genes during SE. This study investigated the global and gene-specific changes in histone acetylation in Arabidopsis explants undergoing SE and identified H3 and H4 acetylation as potential regulators of critical TF genes. The findings also revealed that HDA19 negatively affects SE by regulating LEC1, LEC2, and BBM, and provided evidence of HDA19's involvement in histone acetylation-mediated regulation of LEC2 during SE.
Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Cell Biology
Rong Huang, Liyan Sui, Cong Fu, Yanhui Zhai, Xiangpeng Dai, Sheng Zhang, Ziyi Li
Summary: Inhibition of HDAC11 significantly affects meiosis by altering acetylation levels of key molecules, leading to disrupted maturation of porcine oocytes and compromised subsequent embryo development.
Article
Multidisciplinary Sciences
Seung Hee Choi, Woo Seok Ahn, Myoung Hui Lee, Da Mon Jin, Areum Lee, Eun Yee Jie, Su Ji Ju, Sung Ju Ahn, Suk Weon Kim
Summary: Whole-plant regeneration through plant tissue culture is a complex process regulated by genetic and environmental factors. Epigenetic regulation has been found to play a crucial role in plant cell differentiation and pluripotency. In this study, the effects of epigenetic regulators on lettuce and tobacco protoplasts were tested, and it was found that these chemicals promoted cell division and callus formation. These findings suggest that these chemicals can be used to enhance plant regeneration and crop improvement.
Article
Biology
Annika Muller-Eigner, Adrian Sanz-Moreno, Irene de-Diego, Anuroop Venkateswaran Venkatasubramani, Martina Langhammer, Raffaele Gerlini, Birgit Rathkolb, Antonio Aguilar-Pimentel, Tanja Klein-Rodewald, Julia Calzada-Wack, Lore Becker, Sergio Palma-Vera, Benedikt Gille, Ignasi Forne, Axel Imhof, Chen Meng, Christina Ludwig, Franziska Koch, John T. Heiker, Angela Kuhla, Vanessa Caton, Julia Brenmoehl, Henry Reyer, Jennifer Schoen, Helmut Fuchs, Valerie Gailus-Durner, Andreas Hoeflich, Martin Hrabe de Angelis, Shahaf Peleg
Summary: This study further characterizes the non-inbred Titan (also known as DU6) mouse line, which could be a useful model for obesity research. The results suggest that Titan mice are metabolically unhealthy obese and short-lived, with line-specific patterns of genetic invariability corresponding to observed phenotypic traits. Dietary intervention can partially reverse the metabolic phenotype and extend the lifespan of Titan mice. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seung Hee Choi, Myoung Hui Lee, Da Mon Jin, Su Ji Ju, Woo Seok Ahn, Eun Yee Jie, Ji Min Lee, Jiyoung Lee, Cha Young Kim, Suk Weon Kim
Summary: TSA treatment increases the efficiency of CRISPR/Cas9-mediated genome editing in plant cells by regulating chromatin de-condensation, especially in lettuce and tobacco protoplasts, showing a concentration-dependent increase in indel frequency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yeong Lee, Hanna Kim, Areum Jo, Rin Khang, Chi-Hu Park, Soo-Jeong Park, Eunsang Kwag, Joo-Ho Shin
Summary: The interaction between alpha-syn A53T and TADA2a may lead to changes in histone modification, which are associated with neurotoxicity in the pathology of PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Kenya Bonitto, Kirthana Sarathy, Kaiser Atai, Mithun Mitra, Hilary A. Coller
Summary: This article discusses the epigenetic changes during cell entry into and exit from quiescence, examines the role of different histone marks during quiescence, and explores the possibility of a quiescence histone code.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tomoyuki Iwata, Eri Kaneda-Ikeda, Keita Takahashi, Katsuhiro Takeda, Takayoshi Nagahara, Mikihito Kajiya, Shinya Sasaki, Shu Ishida, Minami Yoshioka, Shinji Matsuda, Kazuhisa Ouhara, Tsuyoshi Fujita, Hidemi Kurihara, Noriyoshi Mizuno
Summary: This study aimed to investigate the regulatory mechanism of bone marrow-derived mesenchymal stem cell (BM-MSC) differentiation by humoral factors derived from human periodontal ligament (HPL) cells and human gingival fibroblasts (HGFs). The results showed that histone deacetylase (HDAC) expression and histone H3 acetylation were involved in the regulation of BM-MSC differentiation. In clinical applications, regulation of HDAC expression holds potential for effective periodontal regeneration, particularly bone regeneration.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Erik Elebring, Ville Wallenius, Anna Casselbrant, Neil G. Docherty, Carel W. le Roux, Hanns-Ulrich Marschall, Lars Fandriks
Summary: This study aimed to investigate the effects of diets enriched in fat or carbohydrates on glucose absorption in the healthy jejunum and the underlying mechanisms. The results showed that a fat-enriched diet decreased jejunal glucose absorption through a ketogenesis-induced alteration of histone acetylation. This research provides important insights into the metabolic effects of different diets.
Article
Biochemistry & Molecular Biology
Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P. Boka, Yiman Liu, Guochao Chen, Zhenyang Liu, Kaeli M. Mathias, Lingbo Xia, Qinglan Li, Mustafa Mir, Yuanyuan Li, Haitao Li, Liling Wan
Summary: Growing evidence suggests the presence of transcriptional condensates on chromatin, but their formation mechanisms and functional significance are still unclear. This study reveals that mutations in the histone acetylation reader ENL can lead to aberrant condensate formation, which drives oncogenic gene activation in human cancer.
Article
Biochemistry & Molecular Biology
Keiichi Ishihara, Eri Kawashita, Ryohei Shimizu, Kazuki Nagasawa, Hiroyuki Yasui, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Nutrition & Dietetics
Azusa Nishino, Takashi Ichihara, Kazuhisa Sugimoto, Takashi Kuriki, Hiroyuki Yasui, Takashi Maoka
NUTRITION RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Yuki Naito, Hiroaki Yamamoto, Yutaka Yoshikawa, Hiroyuki Yasui
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Crystallography
Takayuki Nishiguchi, Masayuki Yamashita, Yutaka Yoshikawa, Hiroyuki Yasui
CRYSTALLOGRAPHY REPORTS
(2019)
Article
Nutrition & Dietetics
Namika Miya, Asuka Uratani, Keita Chikamoto, Yuki Naito, Keiji Terao, Yutaka Yoshikawa, Hiroyuki Yasui
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)
Article
Polymer Science
Bakul Akter, Ariful Islam Khan, Subarna Karmaker, Pollob Ghosh, Soma Saha, Shakil Ahmed Polash, Zinia Islam, Satya Ranjan Sarker, Md Sharif Hossain, Hiroyuki Yasui, Tapan Kumar Saha
Summary: The study revealed a strong interaction between Zinc(II) ions and γ-PGA at pH 5, with binding kinetic data following a pseudo-second-order kinetic model and maximum binding capacity varying with temperature. Zn(γ-PGA) complex exhibited antimicrobial activity against both gram-negative and gram-positive bacteria.
Article
Chemistry, Medicinal
Kenji Arimitsu, Yusuke Yagi, Kazuhiro Koshino, Yukina Nishito, Takahiro Higuchi, Hiroyuki Yasui, Hiroyuki Kimura
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Kenji Arimitsu, Hiroki Iwasaki, Hiroyuki Kimura, Hiroyuki Yasui
Summary: The study found that the rare sugar D-allulose forms high-affinity complexes with boronic acids, with the interaction mainly occurring through the 2,3-hydroxy groups of alpha-allulofuranose in aqueous solution and the 3,5-hydroxy groups of beta-allulopyranose in organic solvents.
Article
Biochemical Research Methods
Yuto Kondo, Hiroyuki Kimura, Chiaki Fukumoto, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui
Summary: This study discussed the advantages and potential of copper-mediated radioiodination using aryl boronic precursors in radiochemistry, with a focus on the impact of protecting groups on radiolabeling efficiency.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2021)
Article
Chemistry, Medicinal
Takenori Furukawa, Hiroyuki Kimura, Hanae Torimoto, Yusuke Yagi, Hidekazu Kawashima, Kenji Arimitsu, Hiroyuki Yasui
Summary: Erythropoietin-producing hepatocellular (Eph) receptors, particularly EphA2, are involved in cancer proliferation and migration. The synthesized imaging tracer [I-123]ETB shows potential for cancer diagnosis by specifically targeting EphA2 receptors using SPECT imaging technology.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Nutrition & Dietetics
Yuki Hashimoto, Katsuhiko Yoshizawa, Yuka Kaido, Akiko Takenouchi, Keiji Terao, Hiroyuki Yasui, Yutaka Yoshikawa
Summary: Studies have shown that the antioxidant capacity of the complex of gamma-cyclodextrin (CD) and alpha-lipoic acid (ALA) is higher than that of free ALA. Supplementation with CD/ALA can improve antioxidant activity and performance during high-intensity exercise.
Article
Biochemistry & Molecular Biology
Fumie Hamano, Suzumi M. Tokuoka, Megumi Ishibashi, Yasuto Yokoi, Dieter M. Tourlousse, Yoshihiro Kita, Yuji Sekiguchi, Hiroyuki Yasui, Takao Shimizu, Yoshiya Oda
Summary: This study explored the relationship between stool condition and various omics data in captive monkeys, focusing on the phenotype of stool water content. By analyzing the monkeys' food intake and evaluating their stool, urine, and plasma, the researchers aimed to understand the health status of individual monkeys comprehensively. The metabolomic, lipidomic, metallomic, and intestinal microbiota analyses suggested correlations between lipid-related metabolites, selenium, bacterial species, and stool water content, raising the hypothesis of redox imbalance causing minor health problems.
Article
Chemistry, Medicinal
K. Yamashita, T. Ogihara, M. Hayashi, T. Nakagawa, Y. Ishizaki, M. Kume, L. Yano, R. Niigata, J. Hiraoka, H. Yasui, T. Nakamura
Article
Infectious Diseases
Yukako Yasui, Hiroyuki Yasui, Kumiko Suzuki, Takako Saitou, Yoshiki Yamamoto, Toshihiko Ishizaka, Kouji Nishida, Shingo Yoshihara, Iwao Gohma, Yoshihiko Ogawa
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Nutrition & Dietetics
Namika Miya, Yuki Naito, Keita Chikamoto, Keiji Terao, Yutaka Yoshikawa, Hiroyuki Yasui
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)