Review
Pharmacology & Pharmacy
Rajan Singh, Hannah Zogg, Uday C. Ghoshal, Seungil Ro
Summary: This article introduces the re-naming of functional gastrointestinal disorders (FGIDs) as disorders of gut-brain interactions. These conditions are common in both clinical practice and the community, and are associated with various pathophysiological mechanisms. Current treatment options include lifestyle modifications and gut microbiota manipulation, but treatment targeting the underlying causes is limited.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
M. Rocio Servin-Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan Loud, Halil Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L. Marshall, Carsten G. Bonnemann, Alexander T. Chesler, Ardem Patapoutian
Summary: The gastrointestinal tract's movements are regulated by the presence of food and play a crucial role in digestion. The lack of PIEZO2 in humans leads to impaired bowel sensation and motility. In mice, Piezo2 in dorsal root neurons is required for sensing gut content and slows down food transit rates in various parts of the gut. This study uncovers the mechanosensory mechanisms that regulate gut transit and have important implications for digestion and waste removal.
Article
Nutrition & Dietetics
Clive H. Wilder-Smith, Andrea Materna, Soren S. Olesen
Summary: Blueberries have beneficial effects on the pathogenesis of functional gastrointestinal disorders. In a double-blind, randomized, cross-over study, patients with FGID received freeze-dried blueberries or placebo. The blueberry treatment group showed improvements in GSRS scores, abdominal symptom relief, quality of life, and life functioning compared to the placebo group.
Review
Food Science & Technology
Tianxu Li, Yuan Wan, Yaqi Meng, Qiaoyun Zhou, Bin Li, Yijie Chen, Ling Wang
Summary: Capsaicin, the main component of red pepper, has shown various bioactivities in recent years. Previous studies have suggested that capsaicin may have potential effects on the treatment of functional dyspepsia (FD), but most research focuses on the relationship between capsaicin and transient receptor potential vanilloid type 1 (TRPV1). However, capsaicin can relieve the symptoms of FD through multiple mechanisms such as desensitizing nociceptive fibers, regulating neurotransmitters, combating viruses and inflammation, balancing gut microbiota, inhibiting gastric acid secretion, and reducing oxidative stress damage.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Medicine, General & Internal
Md Jahangir Alam, Jiande D. Z. Chen
Summary: Abdominal pain is common in FGIDs and affects patients' quality of life. Neural circuits in the brain encode, store, and transfer pain information. Neuroimaging techniques have limitations in studying pain mechanisms due to poor temporal resolution. This review highlights important brain regions involved in pain modulation and proposes extracellular electrophysiology as a suitable method for capturing pain dynamics with high spatiotemporal resolution.
Article
Nutrition & Dietetics
Caterina Strisciuglio, Sabrina Cenni, Maria Rosaria Serra, Pasquale Dolce, Sanja Kolacek, Sara Sila, Ivana Trivic, Michal Rozenfeld Bar Lev, Raanan Shamir, Aco Kostovski, Alexandra Papadopoulou, Eleftheria Roma, Christina Katsagoni, Danijela Jojkic-Pavkov, Angelo Campanozzi, Elena Scarpato, Erasmo Miele, Annamaria Staiano
Summary: 《Mediterranean diet has a protective effect on functional gastrointestinal disorders》
Article
Gastroenterology & Hepatology
Giovanni Sarnelli, Marcella Pesce, Luisa Seguella, Jie Lu, Eleonora Efficie, Jan Tack, Fatima Domenica Elisa De Palma, Alessandra D'Alessandro, Giuseppe Esposito
Summary: The study found that patients with functional dyspepsia show an enhanced response of increased mast cells and their mediators in acidic environment. By modulating TRPV receptors and mast cell activation, PEA could be considered an attractive therapeutic strategy for treating FD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ayesha Shah, Seungha Kang, Nicholas J. Talley, Anh Do, Marjorie M. Walker, Erin R. Shanahan, Natasha A. Koloski, Michael P. Jones, Simon Keely, Mark Morrison, Gerald J. Holtmann
Summary: Patients with functional gastrointestinal disorders (FGIDs) often report intolerance to wheat products. This study compared various factors, including gastrointestinal symptoms, sensory function, psychiatric comorbidities, gut-homing immune cells, and duodenal mucosa-associated microbiome (d-MAM), between FGID patients and controls with and without self-reported wheat sensitivity (SR-NCWS). The results showed that anxiety, visceral sensory function, and specific bacterial taxa were associated with FGID, while gut-homing T-cells were associated with SR-NCWS. The study also found differences in the bacterial genera between the FGID subtypes and controls. Patients with FGID, with or without SR-NCWS, showed increased symptom response and anxiety scores compared to controls.
Article
Clinical Neurology
Caihan Duan, Can Chen, Zhen Ouyang, Chaofan Duan, Shengyan Zhang, Haitao Shang, Lei Zhang, Xuelian Xiang, Jun Song, Kaifang Zou, Tao Bai, Xiaohua Hou
Summary: The study found that the stress level in high school graduates with FGIDs was higher than the control group, and stress was an independent predictor of high-risk FGIDs. Different stressors and reactions to stressors contributed to different FGIDs, and stress also mediated the relationship between factors such as gender, sleep quality, allergies, and FGIDs.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Nutrition & Dietetics
Dominika Glabska, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Guzek
Summary: Vitamin D may have a positive influence on mental health in children, with most studies supporting the association between vitamin D intake/status and mental health components. Therefore, ensuring adequate vitamin D intake in children's daily diet may help prevent or alleviate mental health problems.
Review
Medicine, General & Internal
Angharad Vernon-Roberts, India Alexander, Andrew S. Day
Summary: Functional gastrointestinal disorders (FGID) are common in children, with varying prevalence rates across different age groups. The most common types of FGID differ among infants, toddlers, and older children, serving as benchmark and comparative data for the general population and those with comorbid conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Tarkan Karakan, Ceren Ozkul, Esra Kupeli Akkol, Saniye Bilici, Eduardo Sobarzo-Sanchez, Raffaele Capasso
Summary: The composition and function of gut microbiota play a crucial role in functional gastrointestinal disorders, with a bidirectional communication between the gut and the central nervous system. Antibiotic-induced dysbiosis is identified as a significant factor for the occurrence of these disorders, affecting the gut-brain axis and potentially leading to cognitive and mood disorders. Both animal and human trials provide strong evidence for the causal relationship between gut microbiota and brain functions, highlighting new therapeutic implications for pathogenic pathways.
Review
Nutrition & Dietetics
Valentina Giorgio, Gaia Margiotta, Giuseppe Stella, Federica Di Cicco, Chiara Leoni, Francesco Proli, Giuseppe Zampino, Antonio Gasbarrini, Roberta Onesimo
Summary: Functional gastrointestinal disorders (FGIDs) are common and impactful in children and young adults, but the role of diet in modifying intestinal permeability (IP) in pediatric FGIDs is not well understood. However, small dietary changes such as a low-FODMAP diet, adequate fiber intake, and modulation of gut microbiota through prebiotics and probiotics appear to lead to significant improvements in quality of life for FGID patients.
Review
Pharmacology & Pharmacy
Ramasatyaveni Geesala, You-Min Lin, Ke Zhang, Xuan-Zheng Shi
Summary: Mechano-transcription is a process where mechanical stress alters gene expression, which can lead to pathophysiological changes in gastrointestinal disorders like inflammation, pain, and fibrosis. Studies have shown that persistent mechanical stress in the gut may result in visceral hypersensitivity, inflammation, and fibrosis development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michel Bouchoucha, David Deutsch, Panha Uong, Florence Mary, Jean-Marc Sabate, Robert Benamouzig
Summary: The study found that overlap disorders are common in FGID patients, with most patients suffering from multiple disorders simultaneously. Patients with single FGID had higher BMI and rarely reported IBS, fecal incontinence, and anorectal pain. The clustering of patients with overlap FGIDs resulted in 23 subgroups, each significantly associated with specific disorders.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Debora Compare, Alba Rocco, Marco Sanduzzi Zamparelli, Gerardo Nardone
DIGESTIVE DISEASES
(2016)
Review
Biochemistry & Molecular Biology
Marco Sanduzzi Zamparelli, Debora Compare, Pietro Coccoli, Alba Rocco, Olga Maria Nardone, Giuseppe Marrone, Antonio Gasbarrini, Antonio Grieco, Gerardo Nardone, Luca Miele
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Review
Gastroenterology & Hepatology
Marco Sanduzzi Zamparelli, Alba Rocco, Debora Compare, Gerardo Nardone
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2017)
Article
Gastroenterology & Hepatology
Vincenzo Savarino, Cesare Tosetti, Edoardo Benedetto, Debora Compare, Gerardo Nardone
DIGESTIVE AND LIVER DISEASE
(2018)
Article
Gastroenterology & Hepatology
Gerardo Nardone, Debora Compare, Alberto Martino, Alba Rocco
DIGESTIVE AND LIVER DISEASE
(2018)
Article
Oncology
Sabino Russi, Giovanni Calice, Vitalba Ruggieri, Simona Laurino, Francesco La Rocca, Elena Amendola, Cinzia Lapadula, Debora Compare, Gerardo Nardone, Pellegrino Musto, Mario De Felice, Geppino Falco, Pietro Zoppoli
Article
Gastroenterology & Hepatology
Marco Romano, Antonietta Gerarda Gravina, Gerardo Nardone, Alessandro Federico, Marcello Dallio, Marco Martorano, Caterina Mucherino, Alessandra Romiti, Luciana Avallone, Lucia Granata, Katerina Priadko, Debora Compare, Concetta Tuccillo, Maria Raffaella Romito, Dolores Sgambato, Agnese Miranda, Lorenzo Romano, Carmelina Loguercio, Franco Bazzoli, Rocco Maurizio Zagari
Article
Microbiology
Carmela Nardelli, Ilaria Granata, Valeria D'Argenio, Salvatore Tramontano, Debora Compare, Mario Rosario Guarracino, Gerardo Nardone, Vincenzo Pilone, Lucia Sacchetti
Article
Oncology
Brian I. Carr, Vito Guerra, Rossella Donghia, Fabio Farinati, Edoardo G. Giannini, Luca Muratori, Gian Ludovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Ciro Celsa, Claudia Campani, Andrea Mega, Maria Guarino, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Elisabetta Biasini, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Maurizia Rossana Brunetto, Franco Trevisani
Summary: The study revealed that survival of patients with large hepatocellular carcinoma is influenced by factors including portal vein thrombosis, tumor multifocality, and serum albumin levels. The combination of these factors can help stratify patients into different survival groups.
Article
Nutrition & Dietetics
Alba Rocco, Debora Compare, Costantino Sgamato, Alberto Martino, Luca De Simone, Pietro Coccoli, Maria Laura Melone, Gerardo Nardone
Summary: The study assessed the accuracy of lactose and placebo challenge in diagnosing lactose intolerance in patients with self-reported symptoms, showing that this method accurately determines patients who would benefit from a lactose-free diet.
Letter
Gastroenterology & Hepatology
Alba Rocco, Costantino Sgamato, Debora Compare, Gerardo Nardone
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Alba Rocco, Debora Compare, Costantino Sgamato, Pietro Coccoli, Paolo Chiodini, Gerardo Nardone
Summary: In patients with cirrhosis, omeprazole, esomeprazole, and lansoprazole inhibit microsomal activity, while pantoprazole and rabeprazole do not have a significant impact. If confirmed in larger cohort studies, pantoprazole and rabeprazole could be safely recommended for patients with cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Infectious Diseases
Antonio Riccardo Buonomo, Giulio Viceconte, Debora Compare, Maria Vargas, Carmine Iacovazzo, Emanuela Zappulo, Gerardo Nardone, Giuseppe Servillo, Guglielmo Borgia, Ivan Gentile
Article
Gastroenterology & Hepatology
Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore, Gerardo Nardone
BMC GASTROENTEROLOGY
(2017)
Review
Gastroenterology & Hepatology
Gerardo Nardone, Debora Compare, Alba Rocco
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2017)