Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Article
Oncology
Elisabetta Lolli, Elena De Cristofaro, Irene Marafini, Edoardo Troncone, Benedetto Neri, Francesca Zorzi, Livia Biancone, Emma Calabrese, Giovanni Monteleone
Summary: Patients with long-standing and extensive/left-sided colonic inflammatory bowel diseases (IBD) have a higher risk of developing colorectal cancer. Dye-based chromoendoscopy (DCE) is recommended for surveillance and prevention of colon cancer in these patients. This study identified polypoid lesions with specific morphologic features and size greater than 7 mm as frequently dysplastic/neoplastic and, therefore, should be removed.
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Ola Olen, Michael C. Sachs, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Johan Askling, Anders Ekbom, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Crohn's disease patients are at increased risk of developing small bowel cancer and dying from it, with higher risks for recently diagnosed patients and those with childhood-onset, ileal, and stricturing CD. However, the absolute risks are low overall.
Article
Gastroenterology & Hepatology
Rebecca J. Birch, Nicholas Burr, Venkataraman Subramanian, Jim P. Tiernan, Mark A. Hull, Paul Finan, Azmina Rose, Matthew Rutter, Roland Valori, Amy Downing, Eva J. A. Morris
Summary: This study investigated the epidemiology and outcomes of inflammatory bowel disease-associated colorectal cancer (IBD-CRC). It found that IBD patients have a higher risk of developing CRC, are diagnosed at a younger age, and have worse outcomes compared to sporadic CRC. Further research is needed to understand the reasons behind these differences and inform screening, surveillance, and treatment strategies for this high-risk group.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Thais Gagno Grillo, Ana Elisa Valencise Quaglio, Rodrigo Fedatto Beraldo, Talles Bazeia Lima, Julio Pinheiro Baima, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: miRNAs play a crucial role in regulating gene expression and immune-mediated disorders, particularly in the diagnosis and prognosis of CRC associated with IBD.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Cristina Rubin de Celix, Maria Chaparro, Jose Andres Moreno, Cecilio Santander, Javier P. Gisbert
Summary: This study found a high dysplasia detection rate (24%) in patients with inflammatory bowel disease through targeted chromoendoscopic biopsies. Most lesions were successfully removed by endoscopic resection. Key risk factors for dysplasia were age, lesion morphology, polyp size, and location.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Chanpreet Arhi, Alan Askari, Subramanian Nachiappan, Alex Bottle, Naila Arebi, Thanos Athanasiou, Paul Ziprin, Paul Aylin, Omar Faiz
Summary: The study found that patients with ulcerative colitis (UC) are diagnosed earlier but tend to have worse survival, particularly in terms of nodal disease (stage III). Patients with Crohn's disease (CD)-related CRC appear to have the worst survival compared with both the sporadic and UC groups.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Ana Elisa Valencise Quaglio, Thais Gagno Grillo, Ellen Cristina Souza De Oliveira, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Dysbiosis in the gut microbiota is closely associated with various gastrointestinal disorders such as IBS, IBD, and CRC, potentially leading to mucosal barrier disruption, chronic inflammation, and cancer progression. Specific harmful bacteria, like E. coli and ETBF, are linked to an increased risk of developing CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shailja C. Shah, Steven H. Itzkowitz
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Chronic inflammation plays a key role in the development of neoplastic progression, resulting in dysplastic precursor lesions. Colitis-associated CRC shares molecular similarities with sporadic CRC and the microbiome and host immune system may also play a role. However, further research is needed to understand the specific molecular differences and their role in inflammation-associated cancers.
Article
Gastroenterology & Hepatology
Martin Bortlik, Dana Duricova, Nadezda Machkova, Veronika Hruba, Martin Lukas, Katarina Mitrova, Igor Romanko, Vladislav Bina, Karin Malickova, Martin Kolar, Milan Lukas
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Biochemical Research Methods
Karin Malickova, Dana Duricova, Martin Bortlik, Miroslav Hind'os, Nadezda Machkova, Veronika Hruba, Martin Lukas, Tomas Zima, Milan Lukas
Review
Pharmacology & Pharmacy
Anita Balint, Mariann Rutka, Zsuzsanna Vegh, Zsuzsanna Kurti, Krisztina B. Gecse, Janos Banai, Laszlo Bene, Beata Gasztonyi, Tunde Kristof, Laszlo Lakatos, Pal Miheller, Karoly Palatka, Arpad Patai, Agnes Salamon, Tamas Szamosi, Zoltan Szepes, Gabor Tamas Toth, Aron Vincze, Renata Bor, Agnes Milassin, Anna Fabian, Ferenc Nagy, Martin Kolar, Martin Bortlik, Dana Duricova, Veronika Hruba, Martin Lukas, Katarina Mitrova, Karin Malickova, Milan Lukas, Peter L. Lakatos, Tamas Molnar, Klaudia Farkas
EXPERT OPINION ON DRUG SAFETY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Martin Kolar, Dana Duricova, Martin Bortlik, Veronika Hruba, Nadezda Machkova, Katarina Mitrova, Martin Lukas, Karin Malickova, Milan Lukas
Meeting Abstract
Gastroenterology & Hepatology
Jean Frederic Colombel, Remo Panaccione, Peter Bossuyt, Milan Lukas, Filip J. Baert, Tomas Vanasek, Ahmet Danalioglu, Gottfried Novacek, Alessandro Armuzzi, Xavier Hebuterne, Simon P. Travis, Silvio Danese, Walter Reinisch, William J. Sandborn, Paul Rutgeerts, Daniel Hommes, Stefan Schreiber, Ezequiel Neimark, Bidan Huang, Qian Zhou, Joel H. Petersson, Kori Wallace, Anne M. Robinson, Roopal B. Thakkar, Geert R. D'Haens
Article
Gastroenterology & Hepatology
Bruce E. Sands, William J. Sandborn, Gert Van Assche, Milan Lukas, Jing Xu, Alexandra James, Brihad Abhyankar, Karen Lasch
INFLAMMATORY BOWEL DISEASES
(2017)
Editorial Material
Gastroenterology & Hepatology
Martin Lukas, Martin Bortlik, Bo Shen
Article
Gastroenterology & Hepatology
Dana Duricova, Eva Dvorakova, Ondrej Hradsky, Katarina Mitrova, Marianna Durilova, Jana Kozeluhova, Pavel Kohout, Kristyna Zarubova, Jiri Bronsky, Nora Hradska, Eva Bronska, Miroslava Adamcova, Nadezda Machkova, Veronika Hruba, Martin Bortlik, Martin Lukas, Karin Malickova, Milan Lukas
INFLAMMATORY BOWEL DISEASES
(2019)
Review
Gastroenterology & Hepatology
Bo Shen, Gursimran Kochhar, Udayakumar Navaneethan, Xiuli Liu, Francis A. Farraye, Yago Gonzalez-Lama, David Bruining, Darrell S. Pardi, Martin Lukas, Martin Bortlik, Kaicun Wu, Ajit Sood, David A. Schwartz, William J. Sandborn
GASTROINTESTINAL ENDOSCOPY
(2019)
Review
Gastroenterology & Hepatology
Bo Shen, Gursimran Kochhar, Udayakumar Navaneethan, Francis A. Farraye, David A. Schwartz, Marietta Iacucci, Charles N. Bernstein, Gerald Dryden, Raymond Cross, David H. Bruining, Taku Kobayashi, Martin Lukas, Amandeep Shergill, Martin Bortlik, Nan Lan, Milan Lukas, Shou-Jiang Tang, Paulo Gustavo Kotze, Ravi P. Kiran, Parambir S. Dulai, Sandra El-Hachem, Nayantara Coelho-Prabhu, Shyam Thakkar, Ren Mao, Guodong Chen, Shengyu Zhang, Begona Gonzalez Suarez, Yago Gonzalez Lama, Mark S. Silverberg, William J. Sandborn
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Surgery
Martin Lukas, Martin Kolar, Ondrej Ryska, Stefan Juhas, Jana Juhasova, Jaroslav Kalvach, Jaroslav Pazin, Tereza Kocisova, Ondrej Foltan, Hana Kristianova, Jan Ptacnik, Ivana Vitkova, Martin Bortlik, Milan Lukas
Summary: This study describes a postgraduate endoscopic course on a novel treatment method for anastomotic strictures using a porcine model. The results show that all anastomoses remained passable for endoscopy after 3 months of the course, indicating the success of the training program.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biotechnology & Applied Microbiology
Anita Balint, Mariann Rutka, Martin Kolar, Martin Bortlik, Dana Duricova, Veronika Hruba, Martin Lukas, Katarina Mitrova, Karin Malickova, Milan Lukas, Zoltan Szepes, Ferenc Nagy, Karoly Palatka, Szilvia Lovas, Zsuzsanna Vegh, Zsuzsanna Kurti, Agnes Csontos, Pal Miheller, Tibor Nyari, Renata Bor, Agnes Milassin, Anna Fabian, Kata Szanto, Peter L. Lakatos, Tamas Molnar, Klaudia Farkas
EXPERT OPINION ON BIOLOGICAL THERAPY
(2018)
Article
Gastroenterology & Hepatology
W. Kruis, V. Kardalinos, T. Eisenbach, M. Lukas, T. Vich, I. Bunganic, J. Pokrotnieks, J. Derova, J. Kondrackiene, R. Safadi, D. Tuculanu, Z. Tulassay, J. Banai, A. Curtin, A. E. Dorofeyev, S. F. Zakko, N. Ferreira, S. Bjorck, M. M. Diez Alonso, J. Makela, N. J. Talley, K. Dilger, R. Greinwald, R. Mohrbacher, R. Spiller
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Meeting Abstract
Gastroenterology & Hepatology
M. Kolar, D. Duricova, M. Bortlik, V. Hruba, N. Machkova, K. Mitrova, M. Lukas, K. Malickova, M. Lukas
JOURNAL OF CROHNS & COLITIS
(2017)
Article
Gastroenterology & Hepatology
M. Kolar, D. Duricova, M. Bortlik, V. Hruba, N. Machkova, K. Mitrova, K. Malickova, M. Lukas, Milan Lukas
DIGESTIVE DISEASES
(2017)