期刊
DIGESTIVE DISEASES
卷 27, 期 -, 页码 55-67出版社
KARGER
DOI: 10.1159/000268122
关键词
Irritable bowel syndrome; Animal models; Human experimental medicine models; Drug development; Predictive validity; Intermediate phenotypes
资金
- Boehringer Ingelheim International GmbH
- GSK
- Novartis
- Avera
- Danone
The majority of functional gastrointestinal disorders are characterised by recurrent abdominal pain, with stress playing an important role in first onset and exacerbation of existing symptoms. These disorders are currently defined by symptom criteria, while their pathophysiology remains controversial and incompletely understood. Modeling these disorders in humans and animals has been difficult. While some of the models have adequate face and construct validity, the predictive validity of most of the models has been disappointing, which has put into question the traditional modeling approach. Similar problems have been encountered in drug development for pain and psychiatric disorders. New approaches have been proposed in the form of reverse translation, which include better characterisation of biological intermediate phenotypes in human disease which can be modeled in humans and in animals. Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments. Copyright (C) 2010 S. Karger AG, Basel
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