期刊
DIGESTIVE AND LIVER DISEASE
卷 50, 期 10, 页码 1012-1018出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2018.06.024
关键词
Crohn's disease; Imaging; Inflammatory bowel disease; Magnetic resonance cholangiography; Primary sclerosing cholangitis; Ulcerative colitis
资金
- Ferring
- Takeda
- Vifor Pharma
- Roche
- Merck
- Abbvie
- Janssen
- Genentech
- Mitsubishi
- Norgine
- Tillots
- Vifor
- Pharmacosmos
- BMS
- UCB-pharma
- Hospira
- Celltrion
- Biogaran
- Boerhinger-Ingelheim
- Lilly
- Pfizer
- HAC-Pharma
- Index Pharmaceuticals
- Amgen
- Sandoz
- Forward Pharma GmbH
- Celgene
- Biogen
- Lycera
- Samsung Bioepis
Background: Primary sclerosing cholangitis (PSC) is a major concern in inflammatory bowel disease (IBD). Aims: Evaluating the use of magnetic resonance cholangiography (MRC) as a screening tool for PSC in IBD patients. Methods: A single-center cohort study investigating systematic MRC to assess PSC in IBD patients with (cohort 1) and without (cohort 2) liver function tests (LFTs) abnormality, combined with a retrospective analysis of MRCs in a control group of non-IBD patients with abnormal LFTs (cohort 3). Results: In total, 420 patients (cohort 1: n = 203, cohort 2: n = 30, cohort 3: n = 187) underwent imaging. MRC was classified 'abnormal' in 49/203 (24.1%) patients in cohort 1, in 1/30 (3.3%) patients in cohort 2, and in 66/187 (35.3%) patients in cohort 3 (p < 0.004 for all comparisons). PSC was diagnosed in 20/203 (9.9%) patients in cohort 1, in 1/30 (3.3%) patients in cohort 2, and in 13/187 (7.0%) patients in cohort 3 (p = 0.44). Gamma-glutamyl transpeptidase was the only independent factor predicting the diagnosis of PSC in IBD (OR 1.8, 95% CI 1.3-2.5, p = 0.001). Conclusions: MRC revealed PSC in one tenth of IBD patients with abnormal LFTs and should be systematically performed in IBD patients with abnormal LFTs, especially if gamma-glutamyl transpeptidase level is elevated. (c) 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据