Article
Gastroenterology & Hepatology
Joshua Kwon, Daniela Fluxa, Francis A. Farraye, Paul T. Kroner
Summary: The study found a significant association between IBD and CMV colitis, with a higher occurrence rate in patients with UC. Patients with CD and CMV colitis had increased odds of mortality, shock, and ICU stay, while patients with UC had a higher likelihood of undergoing colectomy. Patients with IBD and CMV colitis also experienced higher odds of acute kidney injury, multiorgan failure, increased hospital costs, and longer hospital stays compared to those without CMV colitis. Prospectively designed studies are needed to further investigate the risk factors and impact of CMV colitis on IBD patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Review
Infectious Diseases
Keyu Ren, Chunming Yong, Yanting Wang, Hongyun Wei, Kun Zhao, Baoguo He, Mingjuan Cui, Yunqing Chen, Jin Wang
Summary: The objective of this review was to explore the association between CMVP and immunosuppressive therapy in IBD patients, and to emphasize the significance of CMV as an opportunistic pathogen and its potential impact on morbidity and mortality. Records and clinical trajectories related to CMVP in IBD patients were retrieved from the PubMed database, with no language barriers. Our findings showed that CMVP primarily occurs during Crohn's disease remission and azathioprine is the main immunosuppressant linked to CMV reactivation. Prompt antiviral therapy can greatly improve patient outcomes, and CMV vaccine might serve as a potential prevention strategy.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Burcu Ozdemir, Ali Atay, Meral Akdogan Kayhan, Yasemin Ozderin Ozin, Dilara Turan Gokce, Adalet Altunsoy, Rahmet Guner
Summary: The study found that tissue CMV-DNA PCR testing is more useful for diagnosing CMV colitis and enables rapid and appropriate treatment.
Review
Medicine, General & Internal
Robert B. Gilmore, Kirstin M. Taylor, C. Orla Morrissey, Bradley J. Gardiner
Summary: This article reviews the available literature and outlines a practical approach to the diagnosis and management of cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD).
INTERNAL MEDICINE JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Miikka Hoyhtya, Katri Korpela, Schahzad Saqib, Sofia Junkkari, Eija Nissila, Anne Nikkonen, Evgenia Dikareva, Anne Salonen, Willem M. de Vos, Kaija-Leena Kolho
Summary: This study aimed to investigate the absolute abundances of gut microbiota in relation to the response to induction therapy with infliximab in pediatric inflammatory bowel disease. The results showed that the treatment responsive group had a higher absolute abundance of Bifidobacteriales and a lower absolute abundance of Actinomycetales compared to the nonresponders. However, the level of inflammation according to fecal calprotectin showed no statistically significant association with the absolute abundances of fecal microbiota. The results on relative abundances differed from the absolute abundances.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Article
Gastroenterology & Hepatology
Mathurin Fumery, Stephane Nancey, Jerome Filippi, Romain Altwegg, Xavier Hebuterne, Gilles Boshetti, Mathilde Barraud, Jonathan Meynier, Stephane Paul, Xavier Roblin
Summary: This study evaluated the effectiveness and safety of golimumab intensification and identified the best threshold of serum golimumab before drug intensification. The results showed that after golimumab intensification, 40% of patients experienced clinical response, 10% experienced clinical remission, 33% experienced endoscopic response, and 23% experienced endoscopic remission.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Veronique Barateau, Loic Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Helenie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stephane Paul, Thierry Walzer, Sophie Trouillet-Assant, Thierry Defrance
Summary: The history of infection and vaccination modality impact the immune memory of individuals vaccinated against SARS-CoV-2. A long-term follow-up study was conducted on unvaccinated and vaccinated COVID-19 convalescent individuals, as well as infection-naive vaccinated individuals, to understand how these factors affect immune memory. The study found that convalescent vaccinated individuals had the highest concentrations of spike protein-specific antibodies and increased frequencies of a specific memory B cell subset, suggesting enhanced protection at mucosal sites.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xavier Roblin, Gerard Duru, Konstantinos Papamichael, Adam S. Cheifetz, Sandy Kwiatek, Anne-Emmanuelle Berger, Mathilde Barrau, Louis Waeckel, Stephane Nancey, Stephane Paul
Summary: Monitoring of anti-drug antibodies in patients on ustekinumab is not recommended due to low immunogenicity. This study aimed to investigate the relationship between anti-drug antibodies and loss of response to ustekinumab in patients with IBD. The results showed that ATU was an independent predictor of LOR to ustekinumab in IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.
Article
Immunology
Melyssa Yaugel-Novoa, Blandine Noailly, Fabienne Jospin, Anne-Emmanuelle Berger, Louis Waeckel, Elisabeth Botelho-Nevers, Stephanie Longet, Thomas Bourlet, Stephane Paul
Summary: The study found that prior immunization did not increase the risk of SARS-CoV-2 infection in COVID-19 patients and vaccinated individuals. There was no enhanced infection effect observed in serum samples from COVID-19 patients with any tested viral variants (Delta and Omicron). Some serum samples from vaccinated individuals showed a mild IgA-ADE effect with Omicron after the completion of the full vaccination scheme, but this effect disappeared.
Article
Immunology
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Nicolas Rochereau, Jade Majorel, Herve Poulet, Blandine Chanut, Lauriane Piney, Egbert Mundt, Stephane Paul
Summary: In this study, the immune responses and protection offered by a canine mucosal vaccine against Bordetella bronchiseptica were investigated using a rat model. The results showed that mucosal vaccination can induce mucosal immune responses and provide protection against a Bb challenge.
Article
Computer Science, Artificial Intelligence
Clement Pealat, Guillaume Bouleux, Vincent Cheutet, Maxime Maignan, Luc Provoost, Sylvie Pillet, Olivier Mory
Summary: During winter, respiratory viruses create immense pressure on Emergency Departments (ED) worldwide. Anticipating the influx of patients with respiratory symptoms is crucial to alleviate hospital stress. However, the lack of systematic testing, as seen in the Covid-19 pandemic, hampers real-time knowledge of the virus' presence in ED patients. To address this issue, a new framework utilizing manifold-based clustering of clinical codes associated with respiratory viruses is proposed. By embedding time series onto the Stiefel manifold and employing density-based clustering (HDBSCAN) enhanced by dimension reduction (UMAP), significant advantages of geometric approaches for time series clustering over traditional methods are demonstrated using real data from two academic hospitals in France.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Martin Fayolle, Amelie Epercieux, Cyrille H. Haddar, Sylvie Pillet, Philippe Berthelot, Bruno Pozzetto, Anne Carricajo, Florence Grattard, Paul O. Verhoeven
Summary: This study assessed the performance of the BD MAX StaphSR assay with liquid Amies elution swabs in routine care of intensive care unit patients. The results showed that the BD MAX StaphSR assay is reliable for S. aureus and MRSA detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Xavier Roblin, Stephane Paul
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Veterinary Sciences
Beatriz Miguelena Chamorro, Gokul Swaminathan, Egbert Mundt, Stephane Paul
Summary: Oral vaccines are convenient to administer and can activate mucosal immune responses. However, preclinical studies using gavage as a technique for oral vaccine administration have limitations. Alternative methods need to be explored.
Review
Virology
Bruno Pozzetto, Gilda Grard, Guillaume Durand, Marie-Claire Paty, Pierre Gallian, Sophie Lucas-Samuel, Stephanie Dieterle, Muriel Fromage, Marc Durand, Didier Lepelletier, Christian Chidiac, Bruno Hoen, Xavier Nicolas de Lamballerie
Summary: Diseases caused by arboviruses are increasing worldwide. Apart from arthropod bites, most arboviruses can be transmitted through other routes. Mainland France and its overseas territories face a complex environment with imported and endemic arboviral diseases, with risks varying by location. This review examines the risks of acquiring arboviral diseases from human products in the French context, focusing on solid organs and hematopoietic stem cells, and outlines the guidelines issued by the French High Council of Public Health.
Review
Medicine, General & Internal
Mathilde Barrau, Xavier Roblin, Leslie Andromaque, Aurore Rozieres, Mathias Faure, Stephane Paul, Stephane Nancey
Summary: Data on the long-term effects of in utero drug exposure on childhood development are lacking, but therapeutic drug monitoring during pregnancy can help limit fetal drug exposure. The levels and duration of drug exposure impact the outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Xavier Roblin, Stephane Nancey, Konstantinos Papamichael, Gerard Duru, Mathurin Flamand, Sandy Kwiatek, Adam Cheifetz, Nicole Fabien, Mathilde Barrau, Stephane Paul
Summary: Higher concentrations of subcutaneous infliximab are associated with better therapeutic outcomes in patients with inflammatory bowel disease, especially deep remission.
JOURNAL OF CROHNS & COLITIS
(2023)