Article
Oncology
Oddry Folkestad, Hans H. Wasmuth, Patricia Mjones, Reidun Fougner, Oyvind Hauso, Reidar Fossmark
Summary: Neuroendocrine tumours of the upper small intestine are rare, slow growing, and can be treated with endoscopic removal or surgery. Long-term survival is associated with tumor growth rate and complete tumor removal, with larger tumors potentially requiring surgery for lymph node metastases. Patients with these tumors generally have long overall survival, and both endoscopic and surgical resections have shown effective results with low recurrence rates.
Article
Oncology
Catherine G. Tran, Scott K. Sherman, Mohammed O. Suraju, Apoorve Nayyar, Henning Gerke, Rami G. El Abiad, Chandrikha Chandrasekharan, Po Hien Ear, Thomas M. O'Dorisio, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
Summary: The management of duodenal neuroendocrine tumors (DNETs) varies depending on the size of the lesion, with smaller ones typically treated by endoscopic mucosal resection (EMR) and larger ones by surgical resection (SR). A study comparing outcomes between patients who underwent EMR and SR showed that there was no significant difference in survival rates, particularly in 1-2 cm DNETs. However, surgically resected DNETs had improved progression-free survival (PFS) and overall survival (OS) compared to jejunoileal NETs.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Clara Meierhofer, Reinhold Fuegger, Matthias Biebl, Rainer Schoefl
Summary: Pancreatic fistulas are a serious complication following surgery or trauma near the pancreas. They can lead to various complications and increasing mortality and morbidity. Treatment options include surgical techniques, conservative measures, and medical treatments, but more research is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Wei On, Wafaa Ahmed, Simon Everett, Matthew Huggett, Bharat Paranandi
Summary: Endoscopic ultrasound (EUS) plays an important role in the management of patients with pancreatic ductal adenocarcinoma (PDAC), not only for diagnosis but also for therapy. It has become a key tool in managing the clinical effects of PDAC, especially in anatomical areas that are difficult to target. It is increasingly used in situations where conventional endoscopy is not possible or unsuccessful, providing a new dimension for the treatment of PDAC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Gyu Young Pih, Ji Yong Ahn, Ji Young Choi, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study analyzed the risk factors and clinical outcomes of hemorrhagic duodenal GISTs, revealing a higher incidence of bleeding compared to gastric GISTs. Age, tumor size, and mitotic count were identified as risk factors for overall survival. Duodenal GISTs have a higher rate of tumor bleeding and re-bleeding after endoscopic hemostasis than gastric GISTs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Clara Meierhofer, Reinhold Fuegger, Georg O. Spaun, Helwig Valentin Wundsam, Patrick Kirchweger, Matthias Biebl, Rainer Schoefl
Summary: Pancreatic fistulas are a serious complication of pancreatic surgery, abdominal trauma, or severe pancreatitis, and can lead to various complications with significant impact on morbidity and mortality. This study analyzed the incidence and management of pancreatic fistulas in a tertiary referral center, with a focus on endoscopic approaches. The findings suggest that an endoscopic transmural approach using lumen-apposing metal stents (LAMS) can be effective in managing pancreatic fistulas.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Guangchen Zu, Weibo Chen, Di Wu, Yue Zhang, Xuemin Chen
Summary: The study analyzed the clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection (DPPHRt) for benign lesions and low-grade malignant tumors of the pancreatic head. The results showed that both robot-assisted and laparoscopic procedures were successful in preserving organs and achieving treatment goals, but there were also complications associated with the surgery.
Article
Agriculture, Dairy & Animal Science
Sarah Caulfield, Simon L. Priestnall, Aarti Kathrani
Summary: Canine chronic inflammatory enteropathy requires histopathology of intestinal biopsies for definitive diagnosis. Recommendations suggest concurrent duodenal and ileal biopsies for dogs with chronic GI signs, as there may be discrepancies in disease types and severity within different GI locations.
Review
Medicine, General & Internal
Emily Truong, Stephen Pandol, Christie Jeon
Summary: This review examines the role of pancreatic steatosis in the development of pancreatic cancer through epidemiological studies and experimental animal models. It highlights the prevalence of pancreatic steatosis and its association with pancreatic cancer. The review also explores the cellular mechanisms underlying pancreatic steatosis and its impact on the tumor microenvironment, as well as the effects of bariatric surgery. Additionally, it identifies gaps in current knowledge and proposes future research directions for understanding the mechanisms of other obesity-associated cancers.
Article
Oncology
Benno Traub, Karl-Heinz Link, Marko Kornmann
Summary: Pancreatic cancer presents unique challenges to clinicians, researchers, and patients due to its distinct biology. While surgery remains the only curative option, new developments in neoadjuvant and adjuvant treatments are emerging, offering hope for more successful ways to cure the disease.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Kjetil Soreide, Elena Rangelova, Christina Dopazo, Sven Mieog, Stefan Staettner
Summary: The need for a standardized education and training track in surgical oncology across Europe is emphasized. ESSO offers hands-on courses and face-to-face discussions for skills training. The UEMS/EBSQ fellowship exam tests core competencies in candidates' specialized areas of expertise, but lacks a standardized set of points for each cancer type. This article outlines pancreatic cancer as part of an optimal practice in surgical oncology.
Article
Gastroenterology & Hepatology
Mantaj S. Brar, Anthony de Buck van Overstraeten, Nancy N. Baxter
Summary: In patients with medically refractory inflammatory bowel disease who undergo surgery preserving the rectum, the risk of rectal cancer is low and may be further reduced by surveillance endoscopy. Expectant management with surveillance endoscopy could be a reasonable alternative to completion proctectomy in selected patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Oncology
Ahmad Alkhasawneh, Tasnuva Rashid, Ibraheem Mohammed, Basma Elhaddad, Hassan Al-Balas, Mayur Virarkar, Ziad Awad, Brett Baskovich, Arun Gopinath
Summary: This study evaluated the prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma. It found that duodenal wall invasion is associated with lymph node metastasis but not with disease-free/overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sara Broggi, Paolo Passoni, Paolo Tiberio, Alessandro Cicchetti, Giovanni Mauro Cattaneo, Barbara Longobardi, Martina Mori, Michele Reni, Najla Slim, Antonella Del Vecchio, Nadia G. Di Muzio, Claudio Fiorino
Summary: The purpose of this study was to assess the dosimetry predictors of gastric and duodenal toxicities in locally advanced pancreatic cancer (LAPC) patients treated with chemo-radiotherapy in 15 fractions. The study found that restricting the dose volume histograms (DVHs) of the stomach and duodenum to specific values (V44Gy < 9.1 cc, D-0.03 < 47.6 Gy) can reduce the toxicity rate, although the correlation with duodenum D-0.03 was not sufficiently robust.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pediatrics
Jae Young Kim, Myung Seok Shin, Sunho Lee
Summary: This study aimed to explore endoscopic features for early diagnosis of SMAS. The results showed that patients with specific endoscopic findings were more likely to have SMAS, highlighting the importance of timely diagnosis and treatment.
Article
Gastroenterology & Hepatology
Lotte Boxhoorn, Robert C. Verdonk, Marc G. Besselink, Marja Boermeester, Thomas L. Bollen, Stefan A. W. Bouwense, Vincent C. Cappendijk, Wouter L. Curvers, Cornelis H. Dejong, Sven M. van Dijk, Hendrik M. van Dullemen, Casper H. J. van Eijck, Erwin J. M. van Geenen, Muhammed Hadithi, Wouter L. Hazen, Pieter Honkoop, Jeanin E. van Hooft, Maarten A. J. M. Jacobs, June E. C. Kievits, Marnix P. M. Kop, Eva Kouw, Sjoerd D. Kuiken, Michiel Ledeboer, Vincent B. Nieuwenhuijs, Lars E. Perk, Jan-Werner Poley, Rutger Quispel, Rogier J. J. de Ridder, Hjalmar C. van Santvoort, Christina J. Sperna Weiland, Martijn W. J. Stommel, Hester C. Timmerhuis, Ben J. Witteman, Devica S. Umans, Niels G. Venneman, Frank P. Vleggaar, Roy L. J. van Wanrooij, Marco J. Bruno, Paul Fockens, Rogier P. Voermans
Summary: In a multicentre prospective cohort study, patients with infected necrotising pancreatitis who underwent endoscopic drainage were compared. The results showed that LAMS did not reduce the need for necrosectomy and the rate of bleeding complications was similar.
Letter
Gastroenterology & Hepatology
Anke M. Onnekink, Jeanin E. Van Hooft, Rogier P. Voermans
Article
Surgery
W. A. R. Zwaans, J. A. de Bruijn, J. P. Dieleman, E. W. Steyerberg, M. R. M. Scheltinga, R. M. H. Roumen
Summary: The purpose of this study was to examine whether patients tend to overestimate or underestimate their pre-operative pain levels when recalling them in the post-operative phase. The study found that a significant percentage of patients experienced recall bias, leading to misclassification of treatment outcomes.
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Dermatology
Vladica M. Velickovic, Tim Spelman, Michael Clark, Sebastian Probst, David G. Armstrong, Ewout Steyerberg
Summary: This review discusses the development of risk prediction tools for chronic wounds and highlights the importance and challenges of regression-based and machine learning methods. Machine learning may be a powerful adjunct for handling complex risk factors in wound healing.
ADVANCES IN WOUND CARE
(2023)
Article
Gastroenterology & Hepatology
Nadine C. M. van Huijgevoort, Sanne A. M. Hoogenboom, Selma J. Lekkerkerker, Olivier R. Busch, Marco Del Chiaro, Paul Fockens, Inne Somers, Joanne Verheij, Rogier P. Voermans, Marc G. Besselink, Jeanin E. van Hooft
Summary: Background: Follow-up in patients with intraductal papillary mucinous neoplasm (IPMN) aims to detect advanced neoplasia (high-grade dysplasia/cancer) in an early stage. The 2015 American Gastroentero-logical Association (AGA), 2017 International Association of Pancreatology (IAP), and the 2018 European Study Group on Cystic tumours of the Pancreas (European) guidelines differ in their recommendations on indications for surgery. However, it remains unclear which guideline is most accurate in predicting advanced neoplasia in IPMN. Methods: Patients who underwent surgery were extracted from a prospective database (January 2006-January 2021). In patients with IPMN, final pathology was compared with the indication for surgery according to the guidelines. ROC-curves were calculated to determine the diagnostic accuracy for each guideline. Results: Overall, 247 patients underwent surgery for cystic lesions. In 145 patients with IPMN, 52 had advanced neoplasia, of which the AGA guideline would have advised surgery in 14 (27%), the IAP and European guideline in 49 (94%) and 50 (96%). In 93 patients without advanced neoplasia, the AGA, IAP, and European guidelines would incorrectly have advised surgery in 8 (8.6%), 77 (83%) and 71 (76%). Conclusion: The European and IAP guidelines are clearly superior in detecting advanced neoplasia in IPMN as compared to the AGA, albeit at the cost of a higher rate of unnecessary surgery. To harmonize care and to avoid confusion caused by conflicting statements, a global evidence-based guideline for PCN in collaboration with the various guidelines groups is required once the current guidelines require an update. (c) 2023 Published by Elsevier B.V. on behalf of IAP and EPC.
Article
Surgery
Myrte Gorris, Frederike Dijk, Arantza Farina, Johannes B. Halfwerk, Gerrit K. Hooijer, Selma J. Lekkerkerker, Rogier P. Voermans, Mattheus C. Wielenga, Marc G. Besselink, Jeanin E. van Hooft
Summary: This study assessed the value of combined CEA and glucose testing in pancreatic cyst fluid, and found that this method has high specificity and sensitivity for differentiating mucinous from non-mucinous pancreatic cystic neoplasms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, Research & Experimental
Florence E. M. de Rijk, Charlotte L. van Veldhuisen, Marc G. Besselink, Jeanin E. van Hooft, Hjalmar C. van Santvoort, Erwin J. M. van Geenen, Cornelis H. van Werkhoven, Pieter Jan F. de Jonge, Marco J. Bruno, Robert C. Verdonk
Summary: This study aims to evaluate the effectiveness of patient education and standardization of care in improving the quality of life and reducing pain severity in patients with chronic pancreatitis. It uses an evidence-based integrated management algorithm and compares it with current practice. The study's primary outcomes include quality of life and pain level, while secondary outcomes include clinical results, healthcare resource utilization, and social participation level. The study is expected to last for 35 months.
Article
Health Care Sciences & Services
Siri L. van der Meijden, Anne A. H. de Hond, Patrick J. Thoral, Ewout W. Steyerberg, Ilse M. J. Kant, Giovanni Cina, M. Sesmu Arbous
Summary: This study aimed to investigate physicians' perspectives and decision-making behavior before implementing an AI-CDS tool for predicting readmission and mortality risk after ICU discharge. The survey results showed that most physicians had positive attitudes towards AI and AI-CDS tools, believing that they could support their work. Physicians expressed a willingness to incorporate a discharge AI-CDS tool into their daily clinical practice and recognized its value in their workflows.
JMIR HUMAN FACTORS
(2023)
Article
Health Care Sciences & Services
Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg, David van Klaveren
Summary: This study compared easily applicable risk-based methods to find optimal prediction methods for individualized treatment effects. The linear-interaction model showed optimal or close-to-optimal performance in many simulation scenarios. The restricted cubic splines model was optimal for strong non-linear deviations when sample size was larger.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Medicine, General & Internal
Ben Van Calster, Ewout W. W. Steyerberg, Laure Wynants, Maarten van Smeden
Summary: Clinical prediction models should be validated before implementation, as the performance of a model may vary across patient populations and measurement procedures. Validation studies should focus on understanding and quantifying heterogeneity and monitoring performance over time, to ensure that prediction models remain up-to-date and safe for clinical decision-making.
News Item
Gastroenterology & Hepatology
Berthold Koletzko, Helena Cortez-Pinto, Matthias Lohr, Jeanin van Hooft, Jonas Rosendahl
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
News Item
Gastroenterology & Hepatology
Marjolijn Duijvestein, Reena Sidhu, Alexander Hann, Jeanin van Hooft, Martina Mueller-Schilling
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Health Care Sciences & Services
Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard
Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Shubhayu Bhattacharyay, Pier Francesco Caruso, Cecilia Akerlund, Lindsay D. Wilson, Robert K. Stevens, David W. Menon, Ewout W. Steyerberg, David Nelson, Ari Ercole, CENTER TBI Investigators Participants
Summary: Existing methods to characterise the evolving condition of traumatic brain injury (TBI) patients in the intensive care unit (ICU) do not capture the necessary context for individualising treatment. In this study, the integration of heterogenous data from medical records was used to model the individualised impact of clinical course on 6-month functional outcome. The study showed that static variables accounted for the majority of functional outcome explanation after TBI.
NPJ DIGITAL MEDICINE
(2023)
